Features of the ultrastructure of the cerebellar cortex during postnatal development of animals under conditions of protein-energy insufficiency and subsequent rehabilitation

Medvedev, D. I.; Бабиченко, И. И.; Kravtsova, A. I.; Eremina, I. Z.

doi:10.1007/bf01237285

Cited by 1 publication

(2 citation statements)

References 5 publications

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“…p300 acetylates MDM2 on K182, K185 that also causes HAUSP to bind, deubiquitinate and stabilize MDM2. Similar to Insulin, TGF‐beta also stimulated S166 phosphorylation on MDM2 involving AKT as an upstream kinase 251 . Upon UV treatment MAPKAP kinase 2 has been shown to phosphorylate MDM2 on S157 and S166 252 (Figure 7).…”

Section: P53‐mdm2 Axis Dynamicsmentioning

confidence: 90%

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Working title: Molecular involvement of p53‐MDM2 interactome in gastrointestinal cancers

Yedla,

Bhamidipati,

Syed

et al. 2024

Cell Biochemistry & Function

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The interaction between murine double minute 2 (MDM2) and p53, marked by transcriptional induction and feedback inhibition, orchestrates a functional loop dictating cellular fate. The functional loop comprising p53‐MDM2 axis is made up of an interactome consisting of approximately 81 proteins, which are spatio‐temporally regulated and involved in DNA repair mechanisms. Biochemical and genetic alterations of the interactome result in dysregulation of the p53‐mdm2 axis that leads to gastrointestinal (GI) cancers. A large subset of interactome is well known and it consists of proteins that either stabilize p53 or MDM2 and proteins that target the p53‐MDM2 complex for ubiquitin‐mediated destruction. Upstream signaling events brought about by growth factors and chemical messengers invoke a wide variety of posttranslational modifications in p53‐MDM2 axis. Biochemical changes in the transactivation domain of p53 impact the energy landscape, induce conformational switching, alter interaction potential and could change solubility of p53 to redefine its co‐localization, translocation and activity. A diverse set of chemical compounds mimic physiological effectors and simulate biochemical modifications of the p53‐MDM2 interactome. p53‐MDM2 interactome plays a crucial role in DNA damage and repair process. Genetic aberrations in the interactome, have resulted in cancers of GI tract (pancreas, liver, colorectal, gastric, biliary, and esophageal). We present in this article a review of the overall changes in the p53‐MDM2 interactors and the effectors that form an epicenter for the development of next‐generation molecules for understanding and targeting GI cancers.

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Section: P53‐mdm2 Axis Dynamicsmentioning

confidence: 90%

“…Similar to Insulin, TGF-beta also stimulated S166 phosphorylation on MDM2 involving AKT as an upstream kinase. 251 Upon UV treatment MAPKAP kinase 2 has been shown to phosphorylate MDM2 on S157 and S166 252 (Figure 7). 2).…”

Section: Introduction Of Additional Chemical Groups Alters the Energy...mentioning

confidence: 99%

Working title: Molecular involvement of p53‐MDM2 interactome in gastrointestinal cancers

Yedla,

Bhamidipati,

Syed

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

Features of the ultrastructure of the cerebellar cortex during postnatal development of animals under conditions of protein-energy insufficiency and subsequent rehabilitation

Cited by 1 publication

References 5 publications

Working title: Molecular involvement of p53‐MDM2 interactome in gastrointestinal cancers

Working title: Molecular involvement of p53‐MDM2 interactome in gastrointestinal cancers

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