Features of the Immunological Status in Patients With Different Forms of Transient Disturbances of Cerebral Blood Circulation

Abstract

Objective : to determine special features of the immunological status as a result of immunophenotyping of peripheral blood leukocytes in patients with different transient disturbances of cerebral blood circulation in comparison with patients with stroke. Material and methods . We examined 14 patients with transient ischemic attack (TIA), 7 patients with cerebral hypertensive crisis (CHC), 9 patients with lacunar stroke, and 9 volunteers. All the patients underwent immunophenotyping of peripheral blood leukocytes and their immunoglobulin level was determined by immunoturbodimetrical method on the first day after admission. Results . We have defined the specific features of the inflammatory process presented by activation of the classical way of inflammation in CHC patients on the first day of the illness in the form of increased level of proteins of the complement system, activity of T- and B-cellular links of immunity in a combination with low expression of adhesion molecules. We have revealed depression of T-cellular immunity without activation of B-cellular immunity in TIA group, which distinguishes transient disturbances of cerebral blood circulation from stroke. Conclusion. Absence of the activation of B-cellular immunity in patients with CHC and TIA and low level of the expression of adhesion molecules make the sanogenic potential of transient disturbances of cerebral blood circulation in comparison with stroke.