Features of the current of bronchial asthma in the presence of komorbidy allergic rhinitis

Abstract

Aim - study of the influence of komorbidy allergic rhinitis (AR) on the course of bronchial asthma (BA). Materials and methods. Clinical research, single performed by a survey of 96 patients divided into two groups: the main - 73 patients with BA combined with AR and a group of comparison-23 patients who do not have allergic rhinitis. The data of clinic, bronchial passableness, level of control of asthma, severity of inflammation in bronhopulmonary region on content of nitrogen oxide in exhaled air and in nasal flushes of a number of biochemicals were studied in comparative aspect. Indicators, the manifestation of systemic inflammatory response according to biochemical, immunological indicators and calculated lejkocitarnym indices. Results. It is revealed that activity of inflammatory process in patients with BA without AR is higher both in the bronhopulmonary region and at the system level. At the same time in the period of clinical remission, most of them have sufficiently well functioning protective mechanisms on the part of the antioxidant system, humoral immunity, non-specific protection. Conclusion. When combined BA and AR inflammation at both local and system levels is less pronounced, but the activity of protective mechanisms decreases. In parallel to the growth of violations on the part of cell and humoralal links of immunity in the blood increases the content of Circulating immune complexes, which contributes to the torpor current of inflammation, which is the basis of a more significant violation of bronchial permeability and complicates achieve control of asthma. These changes increase as the duration of the disease both BA and AR, as well as frequency exacerbations of the disease.

Ethnic and Racial Disparities in Clinical Manifestations of Atopic Dermatitis

“…Based on statistical data, a significant percentage of children, ranging from 29% to 35%, who suffer from atopic dermatitis exhibit a susceptibility to developing allergic bronchial asthma [ 12 ]. Moreover, previous studies have demonstrated a significant correlation between atopic dermatitis and rhinitis in children, which substantially increases their susceptibility (about 99.3%) to the development of allergic bronchial asthma.…”

“…It is noteworthy that this condition is also noticed in persons diagnosed with atopic dermatitis. However, it has lately been incorporated into the diagnostic criteria for asthma [ 12 ] The experiment indicated above, and its corresponding findings suggest a notable similarity in the pathophysiology of allergic bronchial asthma and atopic dermatitis. Both disorders are predominantly attributed to aeroallergens, and the symptoms of atopic dermatitis can be intensified by either exposure to or direct contact with these allergens.…”

Atopic Dermatitis—Beyond the Skin

“…Statistically, 29–35% of children with atopic dermatitis develop allergic bronchial asthma, and children with atopic dermatitis who contract rhinitis have a significantly higher risk (99.3% of developing allergic bronchial asthma). An important aspect in the pathophysiology of asthma is bronchial hyper-reactivity, which is also present in patients with atopic dermatitis but absent in the criteria for a diagnosis of asthma [ 28 , 29 ].…”

“…A vast Danish research study demonstrated associations between a mutation on the gene that encodes protocadherin-1 (PCDH1) and asthma, wheezing, and atopic dermatitis in children. An interaction between PCDH-1 and passive exposure to smoke during childhood in the development of asthma was also suggested [ 29 ]. Other studies emphasized the correlation among the age of onset for atopic dermatitis, its severity, and the appearance of asthma and allergic rhinitis.…”