Features of the clinical course of gastroesophageal reflux disease in combination with chronic obstructive

Abstract

The issue of comorbid pathology is the most relevant and requested in recent years. The combined course of gastroesophageal reflux disease (GERD) and chronic obstructive pulmonary disease (COPD) serves as obstacle to successful and rapid recovery of patients in the practice of both general practitioners and other specialists. The aim is to study the change in laboratory tests — Complete Blood Count (CBC), clinical analysis of sputum (CAS) and biochemical analysis at the level of C Reactive Protein and alpha-1-acid glycoprotein (AGP) in patients with mild to moderate GERD with concomitant mild to moderate COPD without risk of adverse events and LF 0–1. Female, male, young and middle-aged patients were examined. Patients were divided into 3 groups: the first group — patients with exacerbation of COPD and existing GERD in remission, the second group — patients with acute GERD and concomitant COPD in remission, the control group with a combination of GERD and COPD without exacerbation, in remission. The study revealed that in the clinical analysis of blood there are increases in hemoglobin, erythrocytes, hematocrit, leukocytes, neutrophils and erythrocyte sedimentation rate in the group of patients with acute COPD. Changes in the level of acute phase parameters were observed in groups of patients with exacerbation. It was found that simple generally accepted laboratory methods are indispensable for differential diagnosis in the presence and exacerbation of the studied comorbid conditions.