Features of selenium metabolism in humans living under the conditions of North European Russia

Паршукова, О. И.; Потолицына, Н. Н.; Шадрина, В. Д.; Chernykh, A.A.; Bojko, Evgeny R.

doi:10.1007/s00420-013-0895-4

Cited by 9 publications

(6 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, Parshukova et al [54] reported the effect of low levels of plasma selenium on GPx activity and thyroid hormone levels in humans living in northern European Russia. Thus, an imbalance in Se and/or I status of animals can result in altered activity of the main antioxidative enzymes, including those closely connected with Se metabolism.…”

Section: Discussionmentioning

confidence: 99%

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

Rýdlová

Růnová

Száková

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

The response of nutrient status and biochemical processes in (i) Wistar and (ii) spontaneously hypertensive (SHR) rats upon dietary intake of selenium- (Se-) enriched defatted rapeseed (DRS) and/or vitamin E fortification was examined to assess the health benefit of DRS in animal nutrition. Twenty-four individuals of each type of rat were used: The control group was fed with an untreated diet (Diet A). In Diets B and C, soybean meal was replaced with defatted DRS, which comprised 14% of the total diet. The selenized DRS application resulted in ~3-fold increase of Se content in the diet. Diet C was also fortified with the addition of vitamin E, increasing the natural content by 30%. The Se content of the blood and kidneys tended to increase in the DRS groups, where the changes were significant (P < 0.05) only in the case of SHR rats. The iodine (I) content and the proportion of iodide in rat livers indicated a lower transformation rate of iodide into organoiodine compounds compared to the control. Slight and ambiguous alterations in the antioxidative response of the rat were observed in the DRS groups, but the addition of vitamin E to the diet helped to moderate these effects.

show abstract

Section: Discussionmentioning

confidence: 99%

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

Rýdlová

Růnová

Száková

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…In this regards, Parshukova et al . [ 8 ] confirmed that low serum selenium levels have an effect on the thyroid hormone levels in North European Russia. Also, another study in China showed that higher plasma selenium was related to lower chance to be affected by hypothyroidism.…”

Section: Introductionmentioning

confidence: 94%

Role of selenium deficiency in pediatrics with acquired hypothyroidism

et al. 2021

View full text Add to dashboard Cite

“…25 E em pacientes com diagnóstico de tireoidite de Hashimoto (TH) e doença de Graves (DG), baixos níveis séricos de selenoproteínas podem representar reações inflamatórias, com consequente aumento no consumo de proteínas dependentes de Se, na tentativa de prevenir a produção dos radicais livres gerados pela agressão autoimune tireoidiana. 24 Parshukova et al, 28 estudando as inter-relações entre níveis sazonais de Se e níveis de hormônios da tireoide ao longo de um ano, verificaram que níveis séricos baixos de Se afetavam os níveis dos hormônios tireoidianos. Além disso, Wu et al 29 realizaram um estudo em que se investigou a prevalência da doença tireoidiana em duas regiões semelhantes, exceto pela grande diferença nas concentrações de Se no solo.…”

Section: Gestantesunclassified

Micronutrient Influence in Thyroid Function: A Review

Nóbrega

2019

International Journal of Nutrology

View full text Add to dashboard Cite

The thyroid produces and secretes adequate amounts of hormones that regulate various physiological processes, including growth, development, metabolism, and reproductive function. The production and metabolism of thyroid hormones are dependent on micronutrients such as iodine, selenium, zinc and iron. Iodine is essential for the proper synthesis of thyroid hormones. The risk of iodine deficiency is high in places where the food consumed comes from iodine-deficient sources. To avoid complications, various government strategies have been developed to enrich food with this element. Selenium is incorporated in the deiodinases, which are enzymes that also play an essential role in the metabolism of thyroid hormones, in addition to contributing to the antioxidant defense in the thyroid. Zinc participates in the process of deiodination, in addition to being necessary for the T3 receptor to adopt its biologically active confirmation. Iron is found in hemeproteins, including thyroid peroxidase (TPO), which participates in the first two stages of thyroid hormone biosynthesis. Deficiencies of these elements can impair thyroid function. In general, the influence of micronutrients on thyroid function reveals the need for more research to increase scientific knowledge so that preventive and therapeutic measures can be taken regarding thyroid dysfunctions, to maintain a healthy thyroid.

show abstract

Features of selenium metabolism in humans living under the conditions of North European Russia

Abstract: Over the course of 1 year, low levels of plasma selenium affect GP activity and thyroid hormone levels in humans living in North European Russia.

Cited by 9 publications

References 48 publications

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

Role of selenium deficiency in pediatrics with acquired hypothyroidism

Micronutrient Influence in Thyroid Function: A Review

Contact Info

Product

Resources

About