Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition

The Interaction Between Coagulation and Complement Cascades in the Management of Thrombotic Microangiopathies Related to Postpartum Hemorrhage

“… 1 who studied the impact of short-term complement inhibition in patients with thrombotic microangiopathy associated with postpartum hemorrhage. 1 We agree with the authors regarding the need to propose a pragmatic management model by presenting a real-world cohort of patients affected by this infrequent complication. Nonetheless, we believe that some aspects deserve further discussion.…”

Response to “Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition”: Still a Long Way to Go

“…We read with interest the work entitled “Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition.” 1 The authors contend that postpartum patients presenting with thrombotic microangiopathy may benefit from short-term C5 inhibition. Several lines of argumentation tend to mitigate this claim.…”