Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways

Longbottom, E. Rebecca; Torrance, Hew D.T.; Owen, Helen; Fragkou, Paraskevi C.; Hinds, C. J.; Pearse, Rupert M; O’Dwyer, Michael J.

doi:10.1097/sla.0000000000001484

Cited by 76 publications

(66 citation statements)

References 32 publications

(46 reference statements)

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“…It may a result of immune compromising effect led by anticancer treatments. [12][13][14] Noteworthy, this study showed that lung cancer was the most common cancer type (accounted for 22.4%), which may have higher susceptibility SARS-CoV-2 infection than other type cancers. There may be two main reasons: (1) lung cancer accounts for a large .…”

Section: Discussionmentioning

confidence: 76%

“…Besides, cancer patients with COVID-19 might have more complications due to their old age, weakened immune system and the side effects of undergoing treatments. 12,14 Therefore, we recommend systemic screening should be conducted among hospitalized cancer patients. In our study, we also observed that ongoing anticancer treatment was interrupted in most patients because of the diagnosis of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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A Multicenter Study of Coronavirus Disease 2019 Outcomes of Cancer Patients in Wuhan, China

Zhang

Wang

Chen

et al. 2020

Preprint

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Background: At present, there is a global pandemic of coronavirus disease 2019 (COVID-19) pneumonia. Two previous case series from China have suggested that cancer patients are at a higher risk of COVID-19 pneumonia, but the reports were limited by small numbers and few clinical information. Objective: To study clinical characteristics and outcomes of cancer patients infected with COVID-19. Design: Retrospective study. Setting: Four designated COVID-16 hospitals in Wuhan, Hubei province, China. Participants: Medical records of 67 cancer patients admitted to hospitals between Jan 5, 2020 to Feb 18, 2020 were included. Measurements: Demographic, clinical, laboratory, radiological and treatment data were collected. Survival data of the cohort was cut-off on Mar 10, 2020. Results: Of the 67 patients (median age: 66 years), the median age of patients who had severe illness was older than that of patients who had mild symptoms (P<0.001). Forty-three (64.2%) patients had other concurrent chronic diseases, and the proportion of severe patients had co-morbidities was higher than patients with mild disease (P=0.004). Twenty-three (34.3%) patients were still at the anticancer treatment phase, but no tumour progression and recurrence was observed for all the patients during the treatment of COVID-19 pneumonia. About 70% of these patients had fever (n=53, 79.1%) and/or cough (n=50, 74.6%). Lymphocytopenia was the main laboratory finding accompanying increased C-reactive protein and procalcitonin in cancer patients, especially in severe cases. By Mar 10, 2020, 18 (26.9%) patients died from COVID-19, and 39 (58.2%) patients have been discharged. The median age of survivors was younger than that of deaths (P=0.014). Lung cancer (n=15, 22.4%) with COVID-19 was the most common cancer type and accounted for the highest proportion COVID-19 resulted deaths (33.3%, 5/15). We observed a tendency that patients at the follow-up phase had a better prognosis than that at anticancer treatment phase (P=0.095). Limitation: This is a retrospective study with only 67 cases from four hospitals. And some specific clinical information was insufficient. Conclusion: This study showed COVID-19 patients with cancer seem to have a higher proportion of severe cases and poorer prognosis. The tendency of poor prognosis was more obvious in patients at anticancer treatment phase. We should pay more intensive attentions to cancer patients infected with COVID-19.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

A Multicenter Study of Coronavirus Disease 2019 Outcomes of Cancer Patients in Wuhan, China

Zhang

Wang

Chen

et al. 2020

Preprint

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“…The safety and management of cancer patients in the current SARS-CoV-2 outbreak is urgent and most cancer clinics need to establish a contingency plan. It is well established that cancer patients are more susceptible to infections because of the immunosuppressive state caused by both anticancer treatments and surgery [1][2][3]. A recent study from Prof He and colleagues shows that the risk of developing severe events in COVID-19 disease is statistically significant higher in patients with cancer, with a hazard ratio of 3.56 [4].…”

Section: All Authors Have Contributed Equallymentioning

confidence: 99%

Managing COVID-19 in the oncology clinic and avoiding the distraction effect

et al. 2020

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“…3,4 Patients with cancer are more susceptible to infection than individuals without cancer because of their systemic immunosuppressive state caused by the malignancy and anticancer treat ments, such as chemotherapy or surgery. [5][6][7][8] Therefore, these patients might be at increased risk of COVID-19 and have a poorer prognosis.…”

mentioning

confidence: 99%

Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China

Liang

Guan

Chen

et al. 2020

The Lancet Oncology

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4,496

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Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways

Abstract: ObjectiveTo evaluate the role of IL-6 pathways in post-operative immune-suppression and to assess the reversibility of this phenomenon.

Cited by 76 publications

References 32 publications

A Multicenter Study of Coronavirus Disease 2019 Outcomes of Cancer Patients in Wuhan, China

A Multicenter Study of Coronavirus Disease 2019 Outcomes of Cancer Patients in Wuhan, China

Managing COVID-19 in the oncology clinic and avoiding the distraction effect

Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China

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