Features of in vitro and in vivo behaviour of magnesium alloy WE43

Lukyanova, E. A.; Anisimova, Natalia; Martynenko, Natalia; Kiselevsky, M. V.; Добаткин, С. В.; Estrin, Yuri

doi:10.1016/j.matlet.2017.12.125

Cited by 33 publications

(22 citation statements)

References 13 publications

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“…The mass loss of the initial alloy was about 83% by the end of the experiment. These data are consistent with the results of the cited article [34] where a comparative analysis of the biodegradation rate of homogenized alloy WE43 in bodily fluids in various conditions was presented. It was established that in vitro biodegradation in FBS was much faster, and was accompanied with a much vigorous gas formation, than in vivo.…”

Section: Resultssupporting

confidence: 92%

“…While the degradation rate was 2.16 ± 0.11 mm/year in the initial state of the alloy, it dropped to 1.58 ± 0.12 mm/year after MAD processing. In the cited article [34], a comparative analysis of the biodegradation rate of homogenized alloy WE43 in bodily fluids in various conditions was conducted. It was established that in vitro biodegradation in FBS was much faster than in vivo, after subcutaneous implantation in test animals.…”

Section: Resultsmentioning

confidence: 99%

“…In earlier work, we tested the biocompatibility of magnesium alloy WE43 in homogenized condition in vitro and in vivo and assessed its biodegradation rate in a standard simulated body fluid represented by fetal bovine serum [34]. Based on the level of hemolysis and cytotoxicity, the alloy was categorized as a biocompatible one.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

et al. 2019

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In this work, the effect of an ultrafine-grained (UFG) structure obtained by multiaxial deformation (MAD) on the mechanical properties, fatigue strength, biodegradation, and biocompatibility in vivo of the magnesium alloy WE43 was studied. The grain refinement down to 0.93 ± 0.29 µm and the formation of Mg41Nd5 phase particles with an average size of 0.34 ± 0.21 µm were shown to raise the ultimate tensile strength to 300 MPa. Besides, MAD improved the ductility of the alloy, boosting the total elongation from 9% to 17.2%. An additional positive effect of MAD was an increase in the fatigue strength of the alloy from 90 to 165 MPa. The formation of the UFG structure also reduced the biodegradation rate of the alloy under both in vitro and in vivo conditions. The relative mass loss after six weeks of experiment was 83% and 19% in vitro and 46% and 7% in vivo for the initial and the deformed alloy, respectively. Accumulation of hydrogen and the formation of necrotic masses were observed after implantation of alloy specimens in both conditions. Despite these detrimental phenomena, the desired replacement of the implant and the surrounding cavity with new connective tissue was observed in the areas of implantation.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

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Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

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“…This was demonstrated by Brooks et al for Acinetobacter baumannii (Ab307) bacteria cultured on AZ91 samples. Similarly, biocorrosion of alloy WE43 was shown to be much slower under in vivo than in vitro conditions. Thus, the present results should not prejudice the outcomes of future in vivo studies on the response of tumor cells to alloy WE43 in various microstructural states.…”

Section: Discussionmentioning

confidence: 94%

Cytotoxicity of biodegradable magnesium alloy WE43 to tumor cells in vitro: Bioresorbable implants with antitumor activity?

et al. 2019

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In this study, a degradable magnesium alloy WE43 (Mg–3.56%Y–2.20%Nd–0.47%Zr) was used as a research object. To refine its microstructure from the initial homogenized one, the alloy was subjected to severe plastic deformation (SPD) by equal channel angular pressing (ECAP). The data presented show that coincubation of tumor LNCaP and MDA‐MB‐231 cells with the WE43 alloy in the homogenized and the ECAP‐processed states led to a decrease in their viability and proliferation. An increase in the concentration of Annexin V(+) cells during coincubation with samples in both microstructural states investigated was also observed. This is associated with the induction of apoptosis in the cell culture through contact with the samples. Concurrently, a significant drop in the concentration of Bcl‐2(+) cells occurred. It was established that ECAP led to an enhancement of the cytotoxic activity of the alloy against tumor cells. This study demonstrated that alloy WE43 can be considered as a promising candidate for application in orthopedic implants in clinical oncology, where it could play a double role of a mechanically stable, yet bioresorbable, scaffold with local antitumor activity. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:167–173, 2020.

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“…Besides the chemical composition, the biomedical properties profile of Mg alloys can be manipulated by tailoring the microstructure by various thermomechanical treatments, of which severe plastic deformation (SPD) is one of the recently emerged tools [29]. What can be stated safely at this stage is that enhancement of mechanical performance (particularly, the ductility and fatigue properties [30,31]) can be achieved with Mg alloys by SPD processes without a loss in their resistance to biocorrosion [32][33][34][35]. Among the procedures devised for deformation processing of wrought Mg alloys, conventional rolling and direct extrusion are the most popular, though they tend to produce the alloys with a strong texture and, therefore, a strongly asymmetrical mechanical response.…”

Section: Introductionmentioning

confidence: 99%

The Functional Properties of Mg–Zn–X Biodegradable Magnesium Alloys

et al. 2020

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The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg–Zn–X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications—mechanical strength, in vitro corrosion resistance and cytotoxic activity—were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg–Zn–Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.

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Features of in vitro and in vivo behaviour of magnesium alloy WE43

Cited by 33 publications

References 13 publications

Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

Cytotoxicity of biodegradable magnesium alloy WE43 to tumor cells in vitro: Bioresorbable implants with antitumor activity?

The Functional Properties of Mg–Zn–X Biodegradable Magnesium Alloys

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