Features of Hormonal Disturbances in Cirrhotic Patients with Hepatic Encephalopathy

Besheer, Tarek; Arafa, Mostafa A.; El-Kannishy, Ghada; El-Hussiny, Mona Abo-Bakr; Rakha, Ehab

doi:10.5005/jp-journals-10018-1040

Cited by 4 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study conducted by Arafa et al . [9] , it was shown that individuals diagnosed with hepatic encephalopathy had elevated levels of prolactin, with a positive correlation between the severity of encephalopathy and the magnitude of prolactin rise. In the current research, the assessment of individuals suffering from end-stage liver disease was effectively conducted using the Model for MELD score, which exhibits a positive correlation with mortality.…”

Section: Discussionmentioning

confidence: 99%

Serum cortisol and prolactin levels as prognostic markers for complications of liver cirrhosis

Ahmed,

Hodeib,

Gawaly

et al. 2023

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

Background: Several endocrine system abnormalities are linked to liver cirrhosis. The objective of this study was to evaluate the prognostic significance of serum cortisol level and serum prolactin level and complications of liver cirrhosis and its severity and follow up mortality on 90 days. Methods: This prospective cohort research was done on10 control and 50 patients and, aged more than 18 years old, with liver cirrhosis and/or its complications. Patients were categorized into 3 groups: Group I (25 patients): Compensated cirrhosis. Group II (25 patients): Decompensated cirrhosis. Group III (10 standards): Normal healthy participants. Results:The sensitivity and specificity for mortality were 82% and 74% for cortisol AM at cut off 101, were 88% and 84% for cortisol PM at cut off 97 ng/dl. Specificity and sensitivity for mortality depended on prolactin level cut off 20 were 68%, 72% respectively. In univariate all items except spontaneous bacterial peritonitis were significant and multivariate all items except urea, creatinine, encephalopathy and hepatorenal syndrome were significant. Conclusions: Higher prolactin and lower cortisol levels could therefore be considered as diagnostic factor of liver cirrhosis Child and its complications. Therefore, cortisol and prolactin can be regarded as a novel prognostic factors of liver cirrhosis and prediction of mortality and morbidity.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum cortisol and prolactin levels as prognostic markers for complications of liver cirrhosis

Ahmed,

Hodeib,

Gawaly

et al. 2023

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

show abstract

Adrenal histological and functional changes after hepatic encephalopathy: From mice model to an integrative bioinformatics analysis

Sepehri

Jahromi²,

Shahbazi³

et al. 2022

Acta Histochemica

View full text Add to dashboard Cite

Serum Prolactin as a Marker of the Severity of Liver Cirrhosis in a Tertiary Hospital in India: A Cross-Sectional Study

Waseem,

Jamal,

Qadir

et al. 2024

Nigerian Journal of Clinical Practice

View full text Add to dashboard Cite

Background: In India, cirrhosis is becoming a growing concern, leading to an unmet need for new non-invasive markers to assess the severity of liver disease. Serum prolactin is one such marker. Aim: To determine the association between serum prolactin, the severity of liver cirrhosis, and its complications such as ascites, hepatic encephalopathy, and esophageal varices. Methods: This cross-sectional study involved 117 patients with liver cirrhosis. They were evaluated for some complications such as ascites, esophageal varices, and hepatic encephalopathy, as well as for severity by using the Child-Turcotte-Pugh (CTP) score. Serum prolactin levels were measured, and their relationship with both the severity and complications of liver cirrhosis was determined. A P value of < 0.05 was considered significant. Results: The mean age of the patients was 48.3 ± 12.08 years, and the majority (80.3%) were males. Seventy-one percent of the patients had elevated serum prolactin levels (>19.40 ng/mL). Elevated serum prolactin was found in approximately 95.0% and 86.8% of patients with hepatic encephalopathy and ascites, respectively. The median serum prolactin levels were significantly associated with esophageal varices grades (P = 0.043) and hepatic encephalopathy (P < 0.001). The sensitivity and specificity of serum prolactin for predicting severe CTP scores were 81.6% and 91.2%, respectively, with a diagnostic accuracy of 87.2%. On multivariate regression analysis, ascites (AOR = 3.8, 95%CI = 1.29–10.98, P = 0.015), hepatic encephalopathy (AOR = 6.1, 95%CI = 0.68–53.78, P = 0.012), CTP class B (AOR = 5.9, 95%CI = 1.39–24.68, P = 0.016), and CTP class C (AOR = 13.4, 95%CI = 2.25–82.21, P = 0.004) were significantly associated with elevated serum prolactin levels. Conclusion: There was a significant association between serum prolactin levels and CTP classes, esophageal varices, ascites, and hepatic encephalopathy in patients with liver cirrhosis.

show abstract

Features of Hormonal Disturbances in Cirrhotic Patients with Hepatic Encephalopathy

Cited by 4 publications

References 34 publications

Serum cortisol and prolactin levels as prognostic markers for complications of liver cirrhosis

Serum cortisol and prolactin levels as prognostic markers for complications of liver cirrhosis

Adrenal histological and functional changes after hepatic encephalopathy: From mice model to an integrative bioinformatics analysis

Serum Prolactin as a Marker of the Severity of Liver Cirrhosis in a Tertiary Hospital in India: A Cross-Sectional Study

Contact Info

Product

Resources

About