Features of histological structure of pancreas in patients with chronic pancreatitis (CP)

Condition component of connective tissue and systemic proteolysis in patients with chronic pancreatitis and obesity

“…Are liable increase of the content of hexosamines and sialic acids, and decrease of the content of seromucoids and ceruloplasminin in the blood of patients with chronic pancreatitis of both groups of comparison (р<0,05) promote organization or "cementation" of collagen fibrils in the extracellular matrix and decrease probability of their resorption. Increase of fucose not bound with protein in patients of the 1 st and 2 nd groups (р<0,05) is indicative of the induction of fucoglycoproteins catabolism processes of the intracellular matrix and it is one of the markers of degradation of normal extracellular matrix [3].…”

“…[1,2,4,5]. A multi component system of collagen anabolism and carbohydrate-protein components of the extracellular matrix (ECM) is opposed by a powerful system of matric proteinases providing resorption of the scarred connective tissue for excessive amount [3].…”

“…The intensity of proteolytic processes is controlled by a number of tissue and plasma proteinase inhibitors (α 2macroglobulin (α 2 -МG), α 1 -inhibitor of proteinase (α 1 -ІP), antithrombin III, tissue inhibitor of matrix metalloproteinase-1 (ТІМP-1) etc.) [3,6,8]. Imbalance of this system can result in prevailing of the processes of protein catabolism performing structural (cellular membrane components) and transport functions, which is a powerful damaging factor [8,9].…”

“…In addition to the factors promoting the progress of pancreas fibrosis with chronic pancreatitis under conditions of obesity (activation of lipid peroxide oxidation, oxidative modification of proteins, the processes of acinar epithelium apoptosis, endotoxicosis, hyper production of cytokines:TNF-α, IL-1β and growth factors: TGF-β1, IGF-1, disorders of arterial perfusion of the pancreas) [2,3,5,6,7] there Буковинський медичний вісник Том 21, № 1 (81), 2017 are functional disorders of the proteinase-inhibitor system (р<0,05). This, in both groups of patients with chronic pancreatitis increased total activity of proteinases (р<0,05), intensity of high and low molecular proteins lysis were found (р<0,05) ( Table 1).…”

“…In particular, we have found a considerable increase of α 2 -MG and α 1 -ІP in the blood of patients with chronic pancreatitis (р<0,05) as compared to the control parameters according to the increase of body weight (Table 1). An imbalanced increase of proteolytic intensity, even under conditions of compensatory increase of their inhibitors activity in patients with chronic pancreatitis results in progressing destruction of the cellular membranes of the pancreatic cells, acceleration of their apoptosis and development of necrosis, aggressive degradation of the key components of the extracellular matrix of the pancreatic tissue [3,4,9]. Afore-mentioned factors are active inductors of both inflammation (with formation of cytolysis of the acinar epithelium) and fibrogenesis processes, that is pathologic reparation of the pancreatic tissue with the elements of the connective tissue with gross disorders of the in tissue architectonics and development of external secretory dysfunction of the pancreas [3].…”