Features of hemodynamics of pulmonary circulation during the diving reflex

Podyacheva, Ekaterina; Zemlyanukhina, Tatyana; Shadrin, Lavrentij; Baranova, Tatyana

doi:10.21638/spbu03.2020.304

Cited by 1 publication

(4 citation statements)

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“…Peripheral vasoconstriction is a universal adaptive reaction of any organism in response to hypoxia of any genesis which helps to redistribute blood flow to the most oxygen-unresistant organs, such as the brain and heart. Notably, in our previous study, we demonstrated for the first time significantly lower tonus of the pulmonary artery in response to the diving reflex [ 17 ], which was confirmed again in the present work. We suggest that this is another reflective reaction similar to the reflective bradycardia and peripheral vasoconstriction of the systemic circulation vessels and that the vessels’ dilation in the pulmonary circulation is a part of the diving reflex.…”

Section: Discussionsupporting

confidence: 91%

“…As a result, this affects autonomic system activity and the type of synaptic signal transduction [ 45 ]. At the same time, studies suggest an association between the female sex hormones and blockade of sympathetic nervous system activation by the vagus nerve [ 17 , 46 , 47 , 48 , 49 , 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is assumed that increased blood flow into the lung vessels has a protective effect and helps to maximize the chest volume [ 16 ]. Using the method of bioimpedance plethysmography, we recently reported pulmonary vessel dilation during imitation of the diving reflex with a latent period of 2–4 s, which indicated that the autonomic nervous system (ANS) acted prior to the hyperbaric factor [ 17 ]. It is known that the pulmonary vessels are innervated by the sympathetic and parasympathetic nerve fibers of the ANS.…”

Section: Introductionmentioning

confidence: 99%

“…Our previous studies have shown that vasoconstriction of the peripheral vessels modulates the β 2 -ARs and bradykinin receptor B2 (BDKR B2), mediating dilation [ 22 ]. Moreover, we have demonstrated a high inter-individual variability of the peripheral vessels’ [ 23 , 24 , 25 ] and pulmonary vessels’ [ 17 ] constriction ability. This observation can be explained by at least two factors: (1) the genetic variation of the receptors that mediate vasoconstriction and vasodilation, and (2) the current hormonal status of a body (i.e., sex hormones).…”

Section: Introductionmentioning

confidence: 99%

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Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes

Baranova

Podyacheva

Zemlyanukhina

et al. 2022

IJMS

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The diving reflex is an oxygen-saving mechanism which is accompanied by apnea, reflex bradycardia development, peripheral vasoconstriction, spleen erythrocyte release, and selective redistribution of blood flow to the organs most vulnerable to lack of oxygen, such as the brain, heart, and lungs. However, this is a poorly studied form of hypoxia, with a knowledge gap on physiological and biochemical adaptation mechanisms. The reflective sympathetic constriction of the resistive vessels is realized via ADRA1A. It has been shown that ADRA1A SNP (p.Arg347Cys; rs1048101) is associated with changes in tonus in vessel walls. Moreover, the Cys347 allele has been shown to regulate systolic blood pressure. The aim of this work was to evaluate whether the ADRA1A polymorphism affected the pulmonary vascular reactions in men and women in response to the diving reflex. Men (n = 52) and women (n = 50) untrained in diving aged 18 to 25 were recruited into the study. The vascular reactions and blood flow were examined by integrated rheography and rheography of the pulmonary artery. Peripheral blood circulation was registered by plethysmography. The ADRA1A gene polymorphism (p.Arg347Cys; rs1048101) was determined by PCR-RFLP. In both men and women, reflective pulmonary vasodilation did occur in response to the diving reflex, but in women this vasodilation was more pronounced and was accompanied by a higher filling of the lungs with blood.. Additionally, ADRA1A SNP (p.Arg347Cys; rs1048101) is associated with sex. Interestingly, women with the Arg347 allele demonstrated the highest vasodilation of the lung vessels. Therefore, our data may help to indicate women with the most prominent adaptive reactions to the diving reflex. Our data also indicate that women and men with the Cys allele of the ADRA1A gene polymorphism have the highest risk of developing lung hypertension in response to the diving reflex. The diving reflex is an oxygen-saving mechanism which is accompanied by apnea, reflex bradycardia development, peripheral vasoconstriction, spleen erythrocyte release, and selective redistribution of blood flow to the organs most vulnerable to lack of oxygen, such as the brain, heart, and lungs. However, this is a poorly studied form of hypoxia, with a knowledge gap on physiological and biochemical adaptation mechanisms.

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Section: Discussionsupporting

confidence: 91%