Features of Antithrombotic Therapy in Patients with Multifocal Arterial Disease

Grachev, V G; Vedenskaya, S. S.; Smolenskaya, O. G.

doi:10.18087/cardio.2021.3.n1498

Cited by 1 publication

(1 citation statement)

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“…For these patients, atrial fibrillation is considered to be the reason for death. Explanations of potential mechanisms include disappearance of atrial contraction, decreased atrioventricular synchrony, increased filling pressure, enhanced cardiac remodeling, deterioration of left ventricular systolic dysfunction, increased incidence of ventricular arrhythmias, and sudden cardiac death [ 22 , 23 ], in which the proportion of patients complicated with ACS is high and the prognosis is poor. So far, the exact mechanism of new atrial fibrillation in patients with acute coronary syndrome is not clear, which may be related to atrial ischemia or atrial infarction, inflammatory reaction, changes in autonomic nervous tension, increased atrial pressure, and so on.…”

Section: Discussionmentioning

confidence: 99%

The Value of Rivaroxaban Combined with Ticagrelor in Antithrombotic Therapy after PCI in Patients with Nonvalvular Atrial Fibrillation with Acute Coronary Syndrome

Liu

Qiu

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Based on a retrospective cohort study, to investigate the value of rivaroxaban combined with ticagrelor in antithrombotic therapy after PCI in patients with nonvalvular atrial fibrillation with acute coronary syndrome. Methods. A total of 60 patients from January 2019 to May 2021 accepted therapy with antithrombotic therapy after PCI. The patients treated with ticagrelor were set as the control group, and those given rivaroxaban combined with ticagrelor were set as the research group. The curative effect, myocardial level, TIMI blood flow grade, platelet aggregation rate, and the incidence of cardiovascular events were taken from the comparisons. Results. The research group’s therapeutic impact was superior to the control group’s therapeutic impact, and the value was higher. After treatment, the myocardial levels of the two groups decreased, and the levels of troponin I, creatine kinase isoenzyme, and hypersensitive C-reactive protein in the research group were greatly less than those in the control group, and the difference was statistically significant ( P < 0.05 ). After operation, the TIMI blood flow classification in the experimental group was better than that in the control group, and the difference was statistically significant ( P < 0.05 ). The experimental group’s platelet aggregation incidence was considerably lower than the control group’s platelet aggregation incidence at 0.5 and 2 hours following surgery, and the difference was statistically significant ( P < 0.05 ). The incidence of acute myocardial infarction, cardiogenic death, and intractable angina pectoris in the research group was significantly lower than that in the control group. Conclusion. Rivaroxaban combined with ticagrelor in the treatment of nonvalvular atrial fibrillation with acute coronary syndrome after percutaneous coronary intervention; the TIMI blood flow grade is better than ticagrelor, which is of great significance to reduce mortality and has high safety in clinical application.

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Section: Discussionmentioning

confidence: 99%