Features of antihypertensive therapy and real-world prescription of selective imidazoline receptor agonists in Russia vs other countries: STRAIGHT study data analysis

Abstract

Analysis of routine clinical practice of hypertensive patient management represents one of the important tools in the search for further ways to minimize hypertension-associated cardiovascular and renal adverse outcomes.
 Aim. To compare the strategies for hypertension management and features of clinical use of I1-imidazoline receptor (I1-IR) agonists in the Russian Federation and other countries where the STRAIGHT (Selective imidazoline receptor agonists Treatment Recommendation and Action In Global management of HyperTension) study was conducted.
 Materials and methods. It was a cross-sectional online study involving physicians of various specializations. The study was conducted from January 18 to July 1, 2019, in seven countries with a high rate of I1-IR agonist prescription, including Russia.
 Results. A total of 125 (4.5%) responders filled out the survey in the Russian Federation, which was somewhat lower than in other countries (6.8%). The participants were mostly general practitioners (54.0%) and cardiologists (42.0%), while in other countries greater diversity was seen. Most Russian physicians (83.0%) seemed to rely on national clinical guidelines in their routine practice, while in other countries the US guidelines were more popular (66.0%). The majority of responders stated that they took into account the traditional risk factors of hypertension when initiating the therapy; every second responder noted if sleep apnea was present. Awareness of I1-IR agonists, their prescription rate and their preference were higher in Russia. The main reported benefits of I1-IR agonists were their efficacy, including in resistant hypertension, and their metabolic effects (in Russia). Most participants preferred I1-IR agonists as third-line therapy (65.0% in Russia vs 60.0% in other countries) and in combination with an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin II receptor blockers (ARB) (55.0% in Russia vs 54.0% in other countries). Compared to responders from other countries, Russian physicians prescribe I1-IR agonists as first-line (15.0% vs 5.0%) and second-line (48.0% vs 21.0%) therapy more often.
 Conclusion. Russian physicians were the most aware of I1-IR agonists and tended to prescribe drugs of this class for hypertension management more often, and I1-IR agonist combination with ACEi was preferable compared to physician responders from other countries. Antihypertensive efficacy and metabolic effects were reported as the major benefits of I1-IR agonist therapy.

Pharmacological Treatment of Arterial Hypertension in Children and Adolescents in Lithuania

“…Both drugs lack pediatric evidence except for the retrospective analysis of lacidipine use in oncohematological patients and highlight the off-label use of AH medications in children [ 32 ]. It is possible that the use of these medications is determined by regional trends in the adult population as a 2019 study showed that moxonidine is more common as firs- and second-line therapy in Russia than in other countries [ 33 ].…”

Hypertension in peri- and postmenopausal women — pathophysiological mechanisms and approaches to treatment

“…Анализ рутинной клинической практики, проведенный в рамках международного исследования STRAIGHT (Selective imidazoline receptor ago nists Treat ment Recommendation and Action In Global management of HyperTension), показал, что в Российской Федерации частота назначения агонистов имидазолиновых рецепторов выше, чем в других странах, участвовавших в исследовании [50]. Обычно агонисты имидазолиновых рецепторов назначали в составе 3-й линии терапии, но в Рос сийской Федерации, в сравнении с другими странами-участницами исследования, чаще были рекомендованы в составе 2-й линии Российский кардиологический журнал 2023; 28 (5) терапии (48% и 21%) или в качестве монотерапии (15% и 5%) [50]. Нередко агонисты I 1 -ими да золиновых рецепторов в составе двойной терапии комбинировали с иАПФ [50].…”

“…Обычно агонисты имидазолиновых рецепторов назначали в составе 3-й линии терапии, но в Рос сийской Федерации, в сравнении с другими странами-участницами исследования, чаще были рекомендованы в составе 2-й линии Российский кардиологический журнал 2023; 28 (5) терапии (48% и 21%) или в качестве монотерапии (15% и 5%) [50]. Нередко агонисты I 1 -ими да золиновых рецепторов в составе двойной терапии комбинировали с иАПФ [50].…”

Influence on the autonomic cardiovascular system regulation in the treatment of hypertension, arrhythmias and heart failure

“…Врачи из России, как и специалисты из других стран, чаще использовали препараты центрального действия в качестве 3-й линии терапии (65% в России и 60% в других странах), при этом препараты назначали в комбинации с иАПФ (55%), в других странах -с БРА (54%). Вместе с тем в России чаще, чем в других странах, использовали препараты центрального действия в качестве первой (15 vs 5%, соответственно) или второй (48 vs 21%, соответственно) линии терапии [34]. Таким образом, врачи России чаще и на более ранних этапах назначали данный класс препаратов для лечения АГ [34].…”

“…Вместе с тем в России чаще, чем в других странах, использовали препараты центрального действия в качестве первой (15 vs 5%, соответственно) или второй (48 vs 21%, соответственно) линии терапии [34]. Таким образом, врачи России чаще и на более ранних этапах назначали данный класс препаратов для лечения АГ [34]. Антигипертензивная эффективность (в т.ч.…”