Features of a rare peripheral primitive neuroectodermal tumour arising from the thoracic spine in a juvenile canine patient

Hespel, Adrien‐Maxence; Swarte, Marie de; Anderson, Kimberly M.; Weiss, Richard C.; Hathcock, John T.

doi:10.1002/vms3.449

Cited by 3 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Central PNETs arising from the brain parenchyma represent 2.8% of all canine cases of primary intracranial neoplasia (Headley et al, 2009;Snyder et al, 2006). PNETs associated with the spinal cord have only been reported in canine (Hespel et al, 2021), camelid (Weiss & Walz, 2009) and bovine (Berrocal et al, 2005) patients. In the canine patient, an extrapleural mass invaded the spinal cord (Hespel et al, 2021), and the camelid patient had a vertebral tumour compressing the spinal cord (Weiss & Walz, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…PNETs associated with the spinal cord have only been reported in canine (Hespel et al., 2021), camelid (Weiss & Walz, 2009) and bovine (Berrocal et al., 2005) patients. In the canine patient, an extrapleural mass invaded the spinal cord (Hespel et al., 2021), and the camelid patient had a vertebral tumour compressing the spinal cord (Weiss & Walz, 2009). As in the present case, an intradural tumour was described in the bovine patient; however, the report described only pathological findings and did not include any imaging findings (Berrocal et al., 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, PNETs associated with the spinal cord have only been reported in canine, camelid and bovine patients. It has been reported that the canine (Hespel et al., 2021) and camelid (Weiss & Walz, 2009) spinal cord can be invaded by an extrapleural mass. Berrocal et al.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Magnetic resonance imaging findings of the primitive neuroectodermal tumour in lumbosacral spinal cord in a cat

Itoi,

Kutara,

Mitsui

et al. 2023

Veterinary Medicine & Sci

View full text Add to dashboard Cite

A 5‐year‐old, castrated, male domestic short‐haired cat presented with neurological deficits in the pelvic limbs, back pain and dysuria. Magnetic resonance imaging showed a mass lesion caudal to the L4 vertebrae. In addition, suspected haemorrhage was observed at the cranial aspect of the mass. There was no evidence to support the presence of extravertebral intrusion or vertebral body, osteolysis. Dorsal laminectomy and durotomy were performed to debulk the intraspinal mass. Histopathological and immunohistochemical assessment revealed a primitive neuroectodermal tumour (PNET). To our knowledge, this is the first report to describe the clinical and pathological features and imaging diagnosis of intraspinal PNET without extraspinal invasion in a cat.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging findings of the primitive neuroectodermal tumour in lumbosacral spinal cord in a cat

Itoi,

Kutara,

Mitsui

et al. 2023

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…In animals, most of the cases described are of central origin, with reports in cattle (Berrocal et al, 2005), dogs (Snyder et al, 2006;Choi et al, 2012), cats (Kitagawa et al, 2003) and nonhuman primates (Johnson et al, 1999). Central PTNE accounts for 2.8% of primary intracranial neoplasms diagnosed in dogs (Snyder et al, 2006;Hespel et al, 2021). Peripheral PTNE are considered uncommon, being difficult to find reports in the literature, and the last ones described were located in the thoracic and lumbar regions of dogs (Snyder et al, 2006;Junginger et al, 2013;Hespel et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Central PTNE accounts for 2.8% of primary intracranial neoplasms diagnosed in dogs (Snyder et al, 2006;Hespel et al, 2021). Peripheral PTNE are considered uncommon, being difficult to find reports in the literature, and the last ones described were located in the thoracic and lumbar regions of dogs (Snyder et al, 2006;Junginger et al, 2013;Hespel et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Primitive neuroectodermal tumor in the cervical spine of a dog - Case Report

Silva,

Sousa,

Néspoli

et al. 2024

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

A case of peripheral primitive neuroectodermal tumor in the cervical region of a canine is described. The patient was a canine, male, five years old, large size, with acute neurological clinical signs, severe neck pain and tetraplegia. On computed tomography, an oval-shaped mass located dorsally to cervical vertebrae C4 to C7 was observed, with infiltration over the spinal cord between vertebrae C4 and C5, discreetly widening the dorsal intervertebral foramina of the cervical vertebrae and compressing the dorsal portion of the spinal cord of this segment. Under microscopy, the neoplastic cells were small, irregular in shape and with scarce cytoplasm. Immunoreactivity for vimentin, which can only be expressed in PTNEs tumors, was decisive for diagnostic confirmation. Additionally, the positivity of the S-100 protein, which is expressed in neuroectodermal cells mainly of the neural crest cells, reinforced the classification as PTNE, and the negativity in the expression for glial fibrillary acidic protein (GFAP) ruled out the presence of small cell glioma of the central nervous system. Based on the clinical history, imaging exams, cellular morphology and mainly on immunohistochemical staining, the diagnosis of primitive neuroectodermal tumor (PTNE) with infiltration and compression of the spinal cord in the cervical region of the dog was confirmed, considered uncommon in this species.

show abstract

Rosettes and pseudorosettes in veterinary neuropathology

Rissi,

Miller

2024

Vet Pathol

View full text Add to dashboard Cite

Rosettes and pseudorosettes are morphologic cell arrangements found in many neuroepithelial neoplasms in human medicine, including embryonal nervous system tumors (neuroblastoma, medulloblastoma, pineoblastoma, and retinoblastoma), non-embryonal nervous system tumors (ependymoma, astrocytoma, oligodendroglioma, and choroid plexus tumors), and other extraneural neuroepithelial neoplasms. Although these structures are also described in neuroepithelial neoplasms of domestic animals, their frequency is still poorly characterized or inconsistently documented in veterinary medicine. Furthermore, rosettes and pseudorosettes need to be interpreted with caution and within a clinical and pathologic context and should not be solely relied upon for diagnostic confirmation of a particular neoplasm. Here, we review the morphologic features and frequency of the most common types of rosettes and pseudorosettes described in neuroepithelial neoplasms of domestic animals, focusing primarily on those occurring in the nervous system and closely associated tissues.

show abstract

Features of a rare peripheral primitive neuroectodermal tumour arising from the thoracic spine in a juvenile canine patient

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 3 publications

References 24 publications

Magnetic resonance imaging findings of the primitive neuroectodermal tumour in lumbosacral spinal cord in a cat

Magnetic resonance imaging findings of the primitive neuroectodermal tumour in lumbosacral spinal cord in a cat

Primitive neuroectodermal tumor in the cervical spine of a dog - Case Report

Rosettes and pseudorosettes in veterinary neuropathology

Contact Info

Product

Resources

About