Features associated with cognitive impairment and dementia in a community-based sample of illiterate elderly aged 75+ years: The Pietà study

Guimarães, Henrique Cerqueira; Cascardo, Jorge Luiz; Beato, Rogério; Barbosa, Maira Tonidandel; Machado, Thaís Helena; Almeida, Mariana Ramos; Ritter, Simone Rios Fonseca; Borges, Karina Braga Gomes; Teixeira, Antônio Lúcio; Caramelli, Paulo

doi:10.1590/s1980-57642014dn82000007

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…The concept of cognitive impairment no dementia encompasses patients with MCI and individuals with cognitive performance lower than expected for age and education, who may or may not decline. 29 , 30 The strength of this study lies in the sample size and differentiated profile, including only patients from a private organization with high educational level, providing relevant data about a population very little studied in our country.…”

Section: Discussionmentioning

confidence: 99%

“…O conceito de comprometimento cognitivo não demência engloba pacientes com CCL e indivíduos com desempenho cognitivo abaixo do esperado para a idade e a escolaridade, que podem ou não declinar. 29 , 30 A força do presente estudo reside no tamanho da amostra e no perfil diferenciado da casuística composta por pacientes de uma instituição privada e com maior nível educacional, fornecendo dados relevantes sobre uma população muito pouco estudada em nosso país.…”

Section: Discussionunclassified

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Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Souza

Barboza

Gasperin

et al. 2019

Einstein (São Paulo)

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Objective: To evaluate the epidemiological profile of patients seen at a dementia outpatient clinic. Methods: A retrospective study conducted by medical record review searching data on sex, race, age, schooling level, and diagnosis of patients seen from 2008 to 2015. Results: A total of 760 patients were studied, with a predominance of female (61.3%; p<0.0001). The mean age was 71.2±14.43 years for women and 66.1±16.61 years for men. The most affected age group was 71 to 80 years, accounting for 29.4% of cases. In relation to race, 96.3% of patients were white. Dementia was diagnosed in 68.8% of patients, and Alzheimer's disease confirmed in 48.9%, vascular dementia in 11.3%, and mixed dementia in 7.8% of cases. The prevalence of dementia was 3% at 70 years and 25% at 85 years. Dementia appeared significantly earlier in males (mean age 68.5±15.63 years). As to sex distribution, it was more frequent in women (59.6%) than in men (40.4%; p<0.0001; OR=2.15). People with higher schooling level (more than 9 years) had a significantly younger age at onset of dementia as compared to those with lower schooling level (1 to 4 years; p=0.0007). Conclusion: Most patients seen in the period presented dementia, and Alzheimer was the most prevalent disease. Women were more affected, and men presented young onset of the disease. Individuals with higher schooling level were diagnosed earlier than those with lower level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionunclassified

Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Souza

Barboza

Gasperin

et al. 2019

Einstein (São Paulo)

View full text Add to dashboard Cite

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“…This provides an examination with higher sensitivity for the initial symptoms of cognitive decline and with specific sub-scores for cognitive domains. 17 When comparing ACE-R performance of patients with cognitive complaints due to dementia, emotional changes, or a combination of the two, the total score for the group with depression was no different from the control group. However, when each cognitive area was analyzed separately, the tests for memory and phonological fluency showed a significantly lower score among depressed subjects.…”

Section: Introductionmentioning

confidence: 94%

Performance of low-educated elders with depression on Addenbrooke's Cognitive Examination-Revised (ace-r) test

Beckert

Loureiro

Menta

et al. 2016

Dement. neuropsychol.

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Along with cognitive disorders, depression has been a concern for mental health services due to its highly debilitating effect on the functioning and quality of life of the elderly. However, there is still little understanding of the cognitive alterations resulting from depression or of the difficult differential diagnosis with mild cognitive impairment (MCI). It is known that performance on cognitive tests is strongly influenced by education but few studies have been conducted involving low-educated populations.Objective: To evaluate the performance of elders with low education and no dementia on Addenbrooke's Cognitive Examination-Revised (ACE-R) test and its cognitive domains, and compare patients with Current Major Depressive Episode (CMDE) against those without depressive symptoms. Methods:A retrospective, cross-sectional analytical study was conducted based on medical files of patients treated at the Cerebral Aging Clinic of the Hospital São Lucas of the PUCRS. The study included 116 individuals with low education (< 8 years of education) aged between 60 and 84 (69.6 ± 6.4) years, with MCDE (N = 41) and controls (N = 75). Results:No significant difference was observed between control and MCDE groups in median scores on the ACE-R, Mini-Mental State Examination, and the five cognitive domains. There was also no difference between the groups on separate analyses of results on the clock drawing test, the categorical verbal and phonological fluency test, and the naming test. Conclusion:The results of this study showed that depressive symptoms did not influence scores on the ACE-R tests conducted in elders with low education.

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“…Hal ini sesuai dengan penelitian lainnya yang menunjukkan tidak ada hubungan bermakna antara rokok dan fungsi kognitif pada lansia illiterate. 41 Selain itu Kuczmarski dkk menunjukan peranan yang merokok pada pendidikan rendah lebih besar terhadap kejadian depresi (43%) dibandingkan gangguan kognitif (3%). 42 Penelitian ini juga tidak mendapatkan hubungan antara APOE e4 dengan kognitif.…”

Section: Pembahasanunclassified

Gangguan Penghidu Sebagai Faktor Risiko Penurunan Fungsi Kognitif Pada Lansia Pendidikan Rendah

Turana¹

2020

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OLFACTORY IMPAIRMENT AS A RISK FACTOR OF COGNITIVE DECLINE IN THE ELDERLY WITH LOW EDUCATIONABSTRACTIntroduction: Olfactory function plays a role in cognitive decline. Olfactory disorders are known to predict faster cognitive decline and indicate nerve degeneration in the brain. Elderly people with lower assessment of olfactory function are associated with decreased memory function. While the elderly with low education are known to have a high risk of developing dementia. So far there has been no research on disorders of olfactory on cognitive function of elderly with low education.Aim: This study aimed to determine the role of olfactory function and other risk factors related to cognitive decline in the elderly with lower education.Method: A nested cohort study design was used in the fostered area of active age research (in the period 2015-2017) at North, West and Central Jakarta, in elderly with lower education. The cognitive function was assessed using the MMSE instrument. Subjects with a decrease of MMSE score more than 2 points compared to baseline were categorized as having cognitive decline. The olfactory assessment was tested using ten aromas that have been standardized, lipid profile, fasting glucose, and APOE were included.Results: There were 148 elderly subjects with lower education background, majority of the respondent was female 114 (77%) with mean of age 70.2±8.9 years old. Our study showed that 64 (43.2%) subjects had cognitive decline with a mean of decreased was -1.02±3.8 after a follow-up of 2 years, bivariate analyses showed smoking habit and olfactory impairment as a risk factor of cognitive decline (p<0.05; OR=3.1; OR=2.6). In multivariate analyses, subjects with olfactory impairment were 2,7 times more likely to have cognitive decline.Discussion: Olfactory disfunction is a risk factor for reduced cognitive function in the elderly with low education.Keywords: Cognitive, elderly, olfactoryABSTRAKPendahuluan: Fungsi penghidu berperan terhadap penurunan fungsi kognitif. Gangguan penghidu diketahui dapat memprediksi penurunan kognitif yang lebih cepat dan mengindikasikan degenerasi saraf di otak. Lansia dengan penilaian fungsi penghidu yang lebih rendah berkaitan dengan penurunan fungsi memori. Sementara lansia dengan pendidikan rendah diketahui mempunyai risiko tinggi terkena demensia. Sejauh ini belum ada penelitian tentang gangguan penghidu terhadap fungsi kognitif lansia berpendidikan rendah.Tujuan: Untuk mengetahui peranan fungsi penghidu dan faktor risiko lainnya terhadap penurunan fungsi kognitif pada lansia pendidikan rendah.Metode: Penelitian dengan desain nested cohort di wilayah binaan active ageing research (periode 2015-2017) yaitu di Jakarta Utara, Jakarta Barat, dan Jakarta Pusat pada lansia dengan pendidikan rendah. Pemeriksaan fungsi kognitif dinilai dengan menggunakan Mini Mental State Examination (MMSE). Subjek dengan penurunan skor MMSE lebih dari 2 poin dibandingkan baseline dikategorikan mengalami penurunan fungsi kognitif. Subjek dilakukan penilaian fungsi penghidu menggunakan 10 aroma yang telah distandarisasi, pemeriksaan profil lipid, gula darah puasa, dan APOE.Hasil: Didapatkan 148 subjek lansia berpendidikan rendah yang mayoritas perempuan (77%) dengan rerata usia 70,2±8,9 tahun. Sebanyak 43,2% lansia mengalami penurunan skor MMSE dengan rerata penurunan sebesar -1,02±3,8 pada pemantauan selama 2 tahun. Analisis bivariat menunjukkan perilaku merokok dan gangguan olfaktori memiliki risiko terhadap penurunan fungsi kognitif (RO=3,1dan RO=2,6; p<0,05). Analisis multivariat menunjukkan subjek dengan gangguan olfaktori memiliki risiko 2,7 kali untuk mengalami penurunan fungsi kognitif.Diskusi: Gangguan olfaktori merupakan faktor risiko penurunan fungsi kognitif pada lansia berpendidikan rendah.Kata kunci: Fungsi penghidu, kognitif, lansia, kognitif, olfaktori

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Features associated with cognitive impairment and dementia in a community-based sample of illiterate elderly aged 75+ years: The Pietà study

Cited by 5 publications

References 22 publications

Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Performance of low-educated elders with depression on Addenbrooke's Cognitive Examination-Revised (ace-r) test

Gangguan Penghidu Sebagai Faktor Risiko Penurunan Fungsi Kognitif Pada Lansia Pendidikan Rendah

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