Features and trends in Helicobacter pylori antibiotic resistance in Lisbon area, Portugal (1990-1999)

Cabrita, José; Oleastro, Mónica; Matos, Rita; Manhente, A.; Cabral, José; Barros, R; Lopes, Ana Isabel; Ramalho, Paulo; Neves, Beatriz; Guerreiro, António Sousa

doi:10.1093/jac/46.6.1029

Cited by 115 publications

(104 citation statements)

References 6 publications

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“…The resistance rate of H. pylori to clarithromycin has been divergent in various studies. For instance, the rate of clarithromycin resistance was reported to be up to 20% in Portugal (12), Saudi Arabia (15), South Korea (16), China (17) and Iran (18), while it has been reported to be 58% in Germany (11) and 32% in Italy (19). In a study carried out by Mohammadi et al (18) in Iran, resistance to clarithromycin was reported to be 17%, which is similar to our findings.…”

Section: Resultssupporting

confidence: 90%

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

Sikarchi

Fozouni

2018

mljgoums

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Background and Objectives: Helicobacter pylori is the most common cause of gastritis and ulcer worldwide. Treatment of such infections may lead to failure due to drug resistance. This study aimed to investigate the antimicrobial effects of bacteria present in camel milk on the growth of drug-resistant clinical isolates of H. pylori.Methods: In this cross-sectional study, biopsy samples from 75 patients with digestive symptoms were transferred to laboratory in transport medium containing homogeneous compounds. In order to isolate H. pylori, urease-positive biopsies were promptly cultured in brucella agar enriched with defibrinated sheep blood and fetal calf serum. Disk diffusion agar test was used to evaluate antibiotic susceptibility and agar well diffusion method was applied to study the antagonistic effect of probiotics isolated from camel milk on the H. pylori isolates.Results: The frequency of H. pylori isolates was 42.7%. The highest rate of resistance was observed against metronidazole (56.3%). In addition, the rate of resistant to amoxicillin, ciprofloxacin, and clarithromycin and tetracycline was 31.3%, 18.8%, 15.6%, respectively. Lactobacillus plantarum (59.3%) was more frequent than other Lactobacillus species. L. plantarum, Lactobacillus fermentum and Lactobacillus casei showed favorable inhibitory effects against the H. pylori isolates, but L. plantarum (with inhibition zone diameter of 20.3 mm) showed the highest inhibitory effect.Conclusion: Considering the increasing rate of drug resistance and the inhibitory effect of probiotics isolated from milk, health providers recommend that promoting consumption of probiotic food seems beneficial for the general population and those suffering from gastrointestinal disorders.

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Section: Resultssupporting

confidence: 90%

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

Sikarchi

Fozouni

2018

mljgoums

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“…6 and 9 . 6 %, respectively (Cabrita et al, 2000). On the other hand, Heep et al (2000) noted that secondary H. pylori resistance to clarithromycin and metronidazole after eradication failure was frequently observed in 75 and 58 % of the strains, respectively, but resistance to ciprofloxacin was observed in only 9 % of the strains.…”

Section: S Fujimura and Othersmentioning

confidence: 99%

In vitro activity of fluoroquinolone and the gyrA gene mutation in Helicobacter pylori strains isolated from children

Fujimura

Kato

Iinuma

et al. 2004

Journal of Medical Microbiology

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Resistance to antibiotics, especially clarithromycin, is the major cause of the failure to eradicate Helicobacter pylori. There are few studies in children concerning fluoroquinolone activity against H. pylori. Primary resistance to antibiotics including fluoroquinolones was studied in 55 H. pylori strains isolated from Japanese children. DNA sequences of the gyrA gene in fluoroquinolone-resistant strains were determined. Twelve strains (21 . 8 %) were resistant to clarithromycin and three (5 . 5 %) were resistant to both levofloxacin and ciprofloxacin. Out of 12 clarithromycin-resistant strains, 11 (91 . 7 %) were susceptible to levofloxacin and ciprofloxacin. Sequence analysis in three fluoroquinolone-resistant strains showed point mutations of the gyrA gene at G271A, G271T and A272G, indicating mutations of the codon Asp91 in the fluoroquinolone-resistance-determining region of the DNA gyrase. The results suggest that fluoroquinolones should be considered as an option for second-or third-line H. pylori eradication therapy in children.

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“…Portugal was reported around the 9.6%, 29 whilst in another study performed in Italy, the resistance was 31%. 30 These differences probably reflect the uses of this compound in other clinical setting, which can vary between countries or regions.…”

mentioning

confidence: 89%

A 10‐day levofloxacin‐based triple therapy in patients who have failed two eradication courses

Gatta

Zullo

Perna

et al. 2005

Aliment Pharmacol Ther

109

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Background: A standard third-line treatment is lacking, and European guidelines recommend performing culture in these patients. However, the use of this procedure as 'routine practice' is definitively not feasible. Aim: To evaluate the eradication rate of a 10-day levofloxacin-based triple therapy in patients who have failed two eradication courses for Helicobacter pylori. Methods: A total of 151 patients with persistent Helicobacter pylori infection after two treatments were studied. Patients were considered positive if two of three endoscopic tests were positive. Susceptibility testing was also performed. Patients received a standard dose of

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Features and trends in Helicobacter pylori antibiotic resistance in Lisbon area, Portugal (1990-1999)

Cited by 115 publications

References 6 publications

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

In vitro activity of fluoroquinolone and the gyrA gene mutation in Helicobacter pylori strains isolated from children

A 10‐day levofloxacin‐based triple therapy in patients who have failed two eradication courses

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