Features and outcomes of neonatal neuroblastoma

Kostyrka, Ben; Li, J.; Soundappan, S.V.S.; Cassey, John; Alvaro, Frank; Pozza, Luciano Dalla; Kumar, Rajendra

doi:10.1007/s00383-011-2937-x

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…The next most common sites, in order to decrease frequency, are the retroperitoneum, posterior mediastinum, and neck [32]. The incidence of neuroblastoma is approximately 1 in 100,000 children, with a mean age of diagnosis of 18 months [77]. The incidence of neuroblastoma in neonates is not as well defined as tumors occur less commonly in this age group compared to older children.…”

Section: Neuroblastomamentioning

confidence: 99%

“…Staging of neuroblastoma follows the International Neuroblastoma Staging System, which considers tumor location, nodal involvement, and the presence of metastases in assessing the burden of disease [79]. The majority of fetal and neonatal cases of neuroblastoma are stage I, stage II, and stage IV-S at the time of diagnosis [32,76,77]. Most tumors also demonstrate favorable histology including N-myc non-amplification, stroma-rich appearance, and aneuploid DNA content [32,76,77].…”

Section: Neuroblastomamentioning

confidence: 99%

“…The majority of fetal and neonatal cases of neuroblastoma are stage I, stage II, and stage IV-S at the time of diagnosis [32,76,77]. Most tumors also demonstrate favorable histology including N-myc non-amplification, stroma-rich appearance, and aneuploid DNA content [32,76,77]. Surgical resection is the principal treatment for localized cases of neuroblastoma.…”

Section: Neuroblastomamentioning

confidence: 99%

“…Chemotherapy is also employed in the neoadjuvant setting for tumors that are initially deemed to be unresectable. Overall, the prognosis for fetal and neonatal neuroblastoma is excellent, with survival ranging from 70 to 100% [32,76,77]. There have been favorable studies that have demonstrated success with observation with small lesions that likely represent neuroblastoma [80].…”

Section: Neuroblastomamentioning

confidence: 99%

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Neonatal Tumors

Gow¹,

Dellinger²

2017

Pediatric and Neonatal Surgery

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Neonatal tumors encompass a group of heterogeneous neoplasms that demonstrate anatomic locations, behavior patterns, histologic features, and treatment responses that are distinct from neoplasms found in older children. The majority of neonatal tumors are benign, with malignant lesions accounting for only 2% of childhood cancers. However, histologically benign tumors can lead to detrimental effects on the fetus and newborn due to their size and location in relation to vital structures. An understanding of the incidence, appearance, and typical locations of neonatal tumors can provide important diagnostic information and guide treatment decisions. Although surgical intervention is the mainstay of therapy for many neonatal tumors, it is important to recognize that some lesions will regress spontaneously, whereas others may respond to noninvasive treatment modalities. In this chapter, we explore the epidemiology of neonatal tumors and provide a location-based classification schema to aid in diagnosis. A summary of the presentation, diagnosis, and management of the most common neonatal tumors is provided as well.

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Section: Neuroblastomamentioning

confidence: 99%

Section: Neuroblastomamentioning

confidence: 99%

Section: Neuroblastomamentioning

confidence: 99%

Section: Neuroblastomamentioning

confidence: 99%

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Neonatal Tumors

Gow¹,

Dellinger²

2017

Pediatric and Neonatal Surgery

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“…The heterogeneity of presentation in this group presents many challenges to oncologists in maintaining a high cure rate with minimizing morbidity from treatment. Even more complex are patients who are diagnosed antenatally or within the first month of life in which the morbidity of surgery needs to be carefully considered [13,14].…”

Section: Introductionmentioning

confidence: 99%

Neuroblastoma in Children Under 12 Months in Singapore—15-Year Experience and Outcomes From KKH

Koh

Soh

Chan

et al. 2015

Fetal and Pediatric Pathology

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Neuroblastoma: A Review of Management and Outcome

Bhatnagar

Sarin

2012

Indian J Pediatr

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Solid tumors in children are a major cause of death in the developed countries and now even in the developing countries. Of these tumors, neuroblastoma, the most common tumor in children, despite extensive and on-going research and clinical trials still remains an enigma. About 50 % of children with neuroblastoma overall succumb to the disease. This tumor generates lot of curiosity in developing newer therapies for management, but creates equal amount of frustration albeit a risk-stratification system, patients with the same clinical-pathologic parameters and being treated with the same protocols may have markedly different clinical courses and outcomes. Most of the neuroblastomas are sporadic but some are familial. This article aims at understanding the different protocols existing for the risk stratification and management of neuroblastomas. Further, it also aims to study the outcomes of the several different stages of the tumor all across the country as well as in India.

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Features and outcomes of neonatal neuroblastoma

Abstract: NNBL is a subset of neuroblastoma with apparent excellent outcome irrespective of the time of diagnosis. Clinical features and outcomes of ADNB are no different to PDNB.

Cited by 5 publications

References 17 publications

Neonatal Tumors

Neonatal Tumors

Neuroblastoma in Children Under 12 Months in Singapore—15-Year Experience and Outcomes From KKH

Neuroblastoma: A Review of Management and Outcome

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