Features and Management of the Pelvic Cancer Pain

“…Based on the knowledge from various published articles, we propose few hypotheses which can be validated in the future which could justify many of the questions that currently remain unanswered. 11,25,31,32 If ACE2 Receptors are Present in the Conjunctiva Hypothesis 1: Past studies during 2004 during the SARS outbreak have found that the tears of SARS patients tested positive for viral nucleic acid. 33 So far, we know that the chromosome of SARS-CoV-2 is 82% similar to that of SARSCoV.…”

Section: The Hypothesis and Requirement Of Further Research To Undersmentioning

confidence: 99%

<p>Unfolding COVID-19: Lessons-in-Learning in Ophthalmology</p>

Sitaula¹,

Khatri²,

Janani³

et al. 2020

OPTH

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Importance: An observant Chinese doctor Li Wenliang became the first physician to alert the world about COVID-19. Being an ophthalmologist himself, he has put the additional onus on us. The fact that the ocular manifestation could be the first presenting feature of novel coronavirus pneumonia should not be ignored and the possibility of spread of SARS-CoV-2 through the ocular secretions cannot be ruled out. However, with breakthroughs still evolving about this disease, the calls are now louder for closer examination on the pathogenesis of conjunctivitis associated with it. Hence, we conducted a scoping review of all available literature till date to fill in the "potential" gaps in currently available knowledge on ocular manifestations of SARS-CoV-2 infection in an attempt to establish continuity in the "chain of information" from December 2019 till April 2020. We also summarize a possible hypothesis on much less understood and highly debated topics on regard to the etiopathogenesis of ocular involvement in SARS-CoV-2 based on either presence or absence of ACE2 receptor in the ocular surface. Methods: We conducted a scoping review search of published and unpublished SARS-CoV-2-related English language articles from December 2019 till mid of April 2020 from the online databases. The findings were summarized using text, tables, diagrams, and flowcharts. Results: The commonest ocular manifestation in SARS-CoV-2 infection is follicular conjunctivitis and has been the first manifestation of SARS-CoV-2 infection in 3 reported cases till date. The ocular surface inoculated with the SARS-CoV-2 leads to the facilitation of the virus to the respiratory system via the lacrimal passage. RT-PCR analysis of the ocular secretions has shown the presence of the SARS-CoV-2 nucleotides indicating the possibility of infection of ocular secretions. ACE2 receptors and its expression on the ocular mucosal surface are linked behind the etiopathogenesis of conjunctivitis. Conclusion: Conjunctivitis can be the presenting manifestation but may go unnoticed due to its mild nature. The ocular surface could serve as the entry gateway for the virus and ocular secretions could play a role in virus shed. The eye care personnel, as well as the general people, need to be more vigilant and adopt protective eye measures.

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“…The assessment of CIPN is not the purpose of this work, thus other works on the topic should be consulted [14]. Yet, the effectiveness of nonpharmacologic interventions, such as electrocutaneous nerve stimulation and acupuncture have been evaluated in more specific reviews [15].…”

Section: Pathophysiology and Features Of Chemotherapy-induced Periphementioning

confidence: 99%

“…Consequently, prevention of CIPN mainly consists of cumulative dosereduction or lower dose-intensities, especially in patients which are at higher risk to develop neurotoxic side effects or in patients which already have neuropathic symptoms due to diabetes mellitus, hereditary neuropathies, or earlier treatment with neurotoxic chemotherapy, as they are more vulnerable for the development of this therapy-related side effect [14] Data on neuroprotective agents to use for the CIPN prevention are still discussed. Although several agents, such as amifostine, glutathione (GSH) and N-acetylcysteine, as well as the calciumchannel antagonist nimodipine, and calcium and magnesium infusions hold promise as possible neuroprotective factors, clinical data on these drugs have shown a lack of efficacy [17,18].…”

Section: Prevention Of Chemotherapy-induced Peripheral Neuropathymentioning

confidence: 99%

Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review

Cascella

Muzio

2017

IJPPE

Self Cite

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Abstract. Chemotherapy-induced peripheral neuropathy (CIPN) is a one of the most common and severe cancer treatment-related adverse effect. It can often cause the stop of the treatment and affects the long-term quality of life of cancer survivors. Unfortunately, there are no effective agent or protocol to prevent with strong evidence of effectiveness this toxicity prevention of CIPN. Thus, CIPN prevention mainly consists of cumulative dose-reduction or lower dose-intensities, especially in higher risk patients. After a brief description of pathophysiology and features of CIPN, the purpose of this study is to analyse the role of standard pharmacological approaches and natural products for prevention of this serious side effect.

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Features and Management of the Pelvic Cancer Pain

Cited by 208 publications

References 0 publications

COVID-19 and quarantine orders: A practical approach

COVID-19 and quarantine orders: A practical approach

<p>Unfolding COVID-19: Lessons-in-Learning in Ophthalmology</p>

Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review

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