Features and distribution of CD8 T cells with human leukocyte antigen class I-specific receptor expression in chronic hepatitis C

Bonorino, Paula; Leroy, Vincent; Dufeu‐Duchesne, Tania; Tongiani-Dashan, Stefania; Stürm, Nathalie; Pernollet, Martine; Vivier, Éric; Zarski, Jean–Pierre; Marche, Patrice N.; Jouvin‐Marche, Evelyne

doi:10.1002/hep.21850

Cited by 28 publications

(26 citation statements)

References 52 publications

(80 reference statements)

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“…Ideally, such experiments should be performed by physiologic stimulation of the TCR with MHC/peptide complexes. However, in line with previous studies, 20,22,25,36 we were unable to determine the natural specificity of KIR-expressing CD8 T cells. In fact, as an example, KIR expression was virtually absent on terminally differentiated CMV-specific CD8 T cells ( Figure 7A-B).…”

Section: Kir ؉ Cd8 T Cells Are Not Educated By Interactions With Cognsupporting

confidence: 37%

“…20,25,41 Although heterogeneous expression of KIRs was noted on Nef-specific CD8 T cells in 4 patients chronically infected with HIV-1, 40 neither CMV-specific nor HIV-1-specific CD8 T cells during acute phases of infection as well as HCV-specific CD8 T cells from patients with chronic infection, all of which display a more immature T-cell differentiation phenotype, show signs of KIR expression. 22,36,41 Thus, from these studies, performed at steady state in healthy individuals as well as during acute and chronic phases of viral infection, there is only limited information on the TCR specificity of KIRexpressing cells.…”

Section: Kir2ds4mentioning

confidence: 99%

“…22,25,[34][35][36] In NK cells, the strength of the inhibitory interaction between KIRs and their cognate HLA class I molecules tunes the functional responsiveness of the cell during their development in an education process termed licensing. 18 However, in mice, intraepithelial T cells were not educated by interactions with self-MHC class I molecules, suggesting that such education is an NK cell-specific process.…”

Section: Kir ؉ Cd8 T Cells Are Not Educated By Interactions With Cognmentioning

confidence: 99%

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CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells

Björkström

Béziat

Cichocki

et al. 2012

Blood

101

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Section: Kir ؉ Cd8 T Cells Are Not Educated By Interactions With Cognsupporting

confidence: 37%

Section: Kir2ds4mentioning

confidence: 99%

Section: Kir ؉ Cd8 T Cells Are Not Educated By Interactions With Cognmentioning

confidence: 99%

See 1 more Smart Citation

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells

Björkström

Béziat

Cichocki

et al. 2012

Blood

101

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“…Although NK cell KIR repertoire is considered stable in time, the frequency of KIR + T cells increases with age, due to accumulation of terminally differentiated T cells 141. Interestingly, HCMV‐specific CD8 T cells almost completely lack KIR expression, and the specificity of KIR‐expressing cells remains largely unknown 2, 5, 7, 151, 179. In contrast, it was shown that KIR + CD4 + T cells display specificity against HCMV but not Epstein–Barr virus or HSV‐1 4.…”

Section: Kir Gene Expressionmentioning

confidence: 99%

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

et al. 2016

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SummaryKiller‐cell immunoglobulin‐like receptors (KIRs) are components of two fundamental biological systems essential for human health and survival. First, they contribute to host immune responses, both innate and adaptive, through their expression by natural killer cells and T cells. Second, KIR play a key role in regulating placentation, and hence reproductive success. Analogous to the diversity of their human leucocyte antigen class I ligands, KIR are extremely polymorphic. In this review, we describe recent developments, fuelled by methodological advances, that are helping to decipher the KIR system in terms of haplotypes, polymorphisms, expression patterns and their ligand interactions. These developments are delivering deeper insight into the relevance of KIR in immune system function, evolution and disease.

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“…ϩ T cells appears to upregulate inhibitory receptors typically expressed on NK cells following an encounter with antigen (4,5,8,11,13,27,28,36). These receptors include members of the killer immunoglobulin-like receptors (KIR) that can be both inhibiting and activating (4,8,31).…”

mentioning

confidence: 99%

Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8 ⁺ T Cells in Human Immunodeficiency Virus Type 1 Infection

Alter

Rihn

Streeck

et al. 2008

J Virol

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Virus-specific CD8+ T cells play a central role in the control of viral infections, including human immunodeficiency virus type 1 (HIV-1) infection. However, despite the presence of strong and broad HIV-specific CD8+ T-cell responses in chronic HIV-1 infection, these cells progressively lose critical effector functions and fail to clear the infection. Mounting evidence suggests that the upregulation of several inhibitory regulatory receptors on the surface of CD8+ T cells during HIV-1 infection may contribute directly to the impairment of T-cell function. Here, we investigated the role of killer immunoglobulin receptors (KIR), which are expressed on NK cells and on CD8+ T cells, in regulating CD8+ T-cell function in HIV-1 infection. KIR expression was progressively upregulated on CD8+ T cells during HIV-1 infection and correlated with the level of viral replication. Expression of KIR was associated with a profound inhibition of cytokine secretion, degranulation, proliferation, and activation by CD8+ T cells following stimulation with T-cell receptor (TCR)-dependent stimuli. In contrast, KIR+ CD8+ T cells responded potently to TCR-independent stimulation, demonstrating that these cells are functionally competent. KIR-associated suppression of CD8+ T-cell function was independent of ligand engagement, suggesting that these regulatory receptors may constitutively repress TCR activation. This ligand-independent repression of TCR activation of KIR+ CD8+ T cells may represent a significant barrier to therapeutic interventions aimed at improving the quality of the HIV-specific CD8+ T-cell response in infected individuals.

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Features and distribution of CD8 T cells with human leukocyte antigen class I-specific receptor expression in chronic hepatitis C

Cited by 28 publications

References 52 publications

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8 ⁺ T Cells in Human Immunodeficiency Virus Type 1 Infection

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Features and distribution of CD8 T cells with human leukocyte antigen class I-specific receptor expression in chronic hepatitis C

Cited by 28 publications

References 52 publications

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8 + T Cells in Human Immunodeficiency Virus Type 1 Infection

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Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8 ⁺ T Cells in Human Immunodeficiency Virus Type 1 Infection