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Fishel, Richard L.

doi:10.1080/2052546.2003.11949292

Cited by 1 publication

(2 citation statements)

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“…The detection of the fluorescent dye in the hair follicles in this experiment is of importance, as the penetration and storage of the shampoo formulation in the hair follicles is necessary for the shampoo to have the desired effect of stimulating growth of hair. In recently performed in vitro experiments, it has been demonstrated that caffeine can stimulate hair growth [12]. Caffeine is a small molecule with good penetration properties [10].…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the penetration and storage of a shampoo formulation containing caffeine into the hair follicles by in vivo laser scanning microscopy

et al. 2007

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Abstract:In the present study, the ability of a shampoo formulation containing caffeine as well as the fluorescent dye fluorescein to penetrate into hair follicles was investigated by in vivo laser scanning microscopy. A contact time of two minutes between the shampoo and the skin surface was sufficient for the formulation to penetrate deeply into the hair follicles and to remain there for up to 48 hours, even after washing. As hair follicles are surrounded by a close network of capillaries, dendritic cells and stem cells, they represent an important target for drug delivery. The results of the present study demonstrated that in vivo laser scanning microscopy is an efficient tool for the investigation of the dermatopharmacokinetics of topically applied molecules and their penetration pathways, as the method yields space-and timeresolved measurements. µmDetection of the fluorescent dye in the hair follicles after 24 hours

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Section: Discussionmentioning

confidence: 99%

“…In in vitro experiments, caffeine could furthermore stimulate hair growth [12]. Therefore, caffeine can be considered to be an important compound for implementation in shampoo formulations.…”

Section: Introductionmentioning

confidence: 99%