Feature-tracking myocardial strain analysis in acute myocarditis: diagnostic value and association with myocardial oedema

Luetkens, Julian A.; Schlesinger‐Irsch, Ulrike; Kuetting, Daniel; Dabir, Darius; Homsi, Rami; Doerner, Jonas; Schmeel, Frederic Carsten; Fimmers, Rolf; Sprinkart, Alois M.; Naehle, Claas P.; Schild, Hans H.; Thomas, Daniel

doi:10.1007/s00330-017-4854-4

Cited by 56 publications

(52 citation statements)

References 29 publications

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“…The main findings of our study are that (1) RV dysfunction may frequently be observed during the acute stage of myocarditis, (2) LV longitudinal strain was the only independent predictor of functional recovery upon follow-up. "Lake Louise" criteria CMR is increasingly used for the diagnosis, evaluation, and followup of patients suffering from myocarditis [7,8,13]. Using standard "Lake Louise" criteria, CMR can reliably detect inflammatory myocardial alteration in the acute setting.…”

Section: Discussionmentioning

confidence: 99%

“…Global systolic radial, circumferential and longitudinal strain and strain rate values were calculated from peak segmental data. Measurements were performed as previously described [13].…”

Section: Analysis Of Left and Right Ventricular Myocardial Strainmentioning

confidence: 99%

“…Myocardial strain analysis can detect regional and global myocardial dysfunction in acute myocarditis and may serve as a new diagnostic CMR target [13,26]. Several case-control studies have described myocardial strain indices to be decreased in acute myocarditis, even in patients with preserved ejection fraction [12,13].…”

Section: Ventricular Function and Strainmentioning

confidence: 99%

“…Another newer CMR technique, which also adds important information to multiparametric myocarditis CMR, is the determination of myocardial strain and deformation parameters using a feature tracking technique [6,11]. Myocardial strain parameters are typically reduced during early-stage pathogenesis [12,13], however, the predictive value of strain parameters for the recovery of LV function is not known. In addition, the predictive value of right ventricular (RV) functional parameters for outcome prediction has only been addressed by a few studies [14], and little is known about RV deformation analysis over the course of acute myocarditis.…”

Section: Introductionmentioning

confidence: 99%

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Left and right ventricular strain in the course of acute myocarditis: a cardiovascular magnetic resonance study

Luetkens

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Kuetting

et al. 2018

Fortschr Röntgenstr

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Section: Discussionmentioning

confidence: 99%

“…Global systolic radial, circumferential and longitudinal strain and strain rate values were calculated from peak segmental data. Measurements were performed as previously described [13].…”

Section: Analysis Of Left and Right Ventricular Myocardial Strainmentioning

confidence: 99%

Section: Ventricular Function and Strainmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Left and right ventricular strain in the course of acute myocarditis: a cardiovascular magnetic resonance study

Luetkens

Petry

Kuetting

et al. 2018

Fortschr Röntgenstr

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“…More recently, the introduction and coupling of the feature-tracking technique with MRI have allowed for the assessment of 3-D regional and global (longitudinal, circumferential, and radial strains) myocardial dysfunction ( 110 , 194 ). While FT MRI has become a popular choice in the clinic for assessment of myocardial strain ( 12 , 111 ), it is still in its infancy in animal models. Nonetheless, a recent study ( 99 ) evaluated FT MRI reproducibility in mice and reported good to excellent inter- and intraobserver reproducibility, suggesting that FT MRI shows analytic potential for experimental cardiac research.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Guidelines for measuring cardiac physiology in mice

Lindsey

Kassiri

Virag

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

253

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Cardiovascular disease is a leading cause of death, and translational research is needed to understand better mechanisms whereby the left ventricle responds to injury. Mouse models of heart disease have provided valuable insights into mechanisms that occur during cardiac aging and in response to a variety of pathologies. The assessment of cardiovascular physiological responses to injury or insult is an important and necessary component of this research. With increasing consideration for rigor and reproducibility, the goal of this guidelines review is to provide best-practice information regarding how to measure accurately cardiac physiology in animal models. In this article, we define guidelines for the measurement of cardiac physiology in mice, as the most commonly used animal model in cardiovascular research.Listen to this article’s corresponding podcast at http://ajpheart.podbean.com/e/guidelines-for-measuring-cardiac-physiology-in-mice/.

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Cardiac involvement in patients recovering from Delta Variant of COVID‐19: a prospective multi‐parametric MRI study

et al. 2022

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AimsThe cardiac injury and sequelae of Delta Variant of coronavirus disease 2019 remain unknown. This study aimed to evaluate the presence of cardiac involvement in patients recovering from Delta Variant of COVID-19 based on multiparametric cardiac magnetic resonance imaging (MRI). Methods and resultsWe prospectively assessed patients recovering from Delta Variant of COVID-19 using multi-parametric cardiac magnetic resonance imaging (MRI) between June 2021 and July 2021. Comparison was made with 25 healthy controls. Forty-four patients (median age 51 years, 28 women) recovering from Delta Variant were recruited and had a median time of 35 days between diagnosis and cardiac MRI. There were no patients with chest pain (0/44, 0%) and high sensitivity cardiac troponin T troponin elevation (median levels 2.20 pg/mL, IQR levels 0.85-4.40 pg/mL). Regarding the cardiac imaging findings, a total of 14 (32%) patients presented cardiac tissue feature abnormalities, and a total of 9 (20%) patients had a myocarditis-like injury based on cardiac MRI 2018 Lake Louise criteria. When we further assessed the T1 and T2 mapping values for of patients' individual, abnormal raised global native T1, T2, and extracellular volume were seen in 6 (14%), 6 (14%), and 4 (9%) patients, respectively. Comparing with controls, the patients had lower LV global longitudinal strain and (À22.2 ± 2.8% vs. À24.6 ± 2.0%, P < 0.001) and global circumferential strain (À20.7 ± 6.8% vs. À24.3 ± 2.9%, P = 0.014), but higher global native T1 (1318.8 ± 55.5 ms vs. 1282.9 ± 38.1 ms, P = 0.006). Four (9%) patients presented myocardial late gadolinium enhancement with subepicardial pattern mostly common seen, and two (5%) patients presented pericardial enhancement. Conclusions The cardiac MRI could detect subclinical functional and myocardial tissue characteristic abnormalities in individuals who were recovering from Delta Variant without cardiac-related clinical findings. The native T1 mapping and strain imaging may be a sensitive tool for the noninvasive detection of a subset of patients who are at risk for cardiac sequelae and more prone to myocardial damage in survivors with Delta Variant.

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Feature-tracking myocardial strain analysis in acute myocarditis: diagnostic value and association with myocardial oedema

Cited by 56 publications

References 29 publications

Left and right ventricular strain in the course of acute myocarditis: a cardiovascular magnetic resonance study

Left and right ventricular strain in the course of acute myocarditis: a cardiovascular magnetic resonance study

Guidelines for measuring cardiac physiology in mice

Cardiac involvement in patients recovering from Delta Variant of COVID‐19: a prospective multi‐parametric MRI study

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