“…Of late, however, a number of semi- and fully-automated methods have been developed to segment normal tissues in a radiotherapy clinical context (Gorthi, Duay, Houhou, Bach Cuadra, Schick, Becker, Allal & Thiran 2009, Malsch, Thieke, Huber & Bendl 2006, Lu, Chen, Olivera, Ruchala & Mackie 2004, Lu, Olivera, Chen, Ruchala, Haimerl, Meeks, Langen & Kupelian 2006, Xie, Chao & Xing 2008, Reed, Woodward, Zhang, Strom, Perkins, Tereffe, Oh, Yu, Bedrosian, Whitman, Bucholz & Dong 2008, Zhang, Chi, Meldolesi & Yan 2007, Pasquier, Lacornerie, Vermandel, Rosseeau, Lartigau & Betrouni 2007, Isambert, Dhermain, Bidault, Commowick, Bondiau, Malandain & Lefkopoulos 2008). Evaluation of these methods has been a persistent challenge as medical image segmentation unfortunately lacks a known ground truth, or gold standard, in its real world application.…”