Feature-Based Anticipation of Cues that Predict Reward in Monkey Caudate Nucleus

Lauwereyns, Johan; Takikawa, Yoriko; Kawagoe, Reiko; Kobayashi, Shunsuke; Koizumi, Masashi; Coe, Brian C.; Sakagami, Masamichi; Hikosaka, Okihide

doi:10.1016/s0896-6273(02)00571-8

Cited by 119 publications

(84 citation statements)

References 53 publications

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“…Recent single-unit recording of neurons in the monkey brain indicates that caudate plays a crucial role in valuation of default actions. Figure 3, adapted from (Lauwereyns, Takikawa et al 2002), provide evidence.…”

Section: Distinguishing Valuation and Choicementioning

confidence: 86%

“…In fact, if percentage correct saccades are an indication, effort is involved in avoiding the default action. Indeed, Lauwereyns et al (2002) reports that the monkey makes more mistakes, i.e., moves its eyes in the wrong direction, when the stimulus requires a saccade in the less rewarding direction.…”

Section: Distinguishing Valuation and Choicementioning

confidence: 99%

“…The difference (bottom graph) is the same for both "Best condition" and "Worst condition"trials. Source: (Lauwereyns, Takikawa et al 2002).…”

Section: Figurementioning

confidence: 99%

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The Neurobiological Foundations of Valuation in Human Decision Making Under Uncertainty

2009

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Section: Distinguishing Valuation and Choicementioning

confidence: 86%

Section: Distinguishing Valuation and Choicementioning

confidence: 99%

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The Neurobiological Foundations of Valuation in Human Decision Making Under Uncertainty

2009

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“…It is also one of several structures in the brain, along with other parts of the basal ganglia and several areas of cortex, that represent the anticipated availability or magnitude of a reward provided in the context of a behavioral task [3]. Indeed, several recent studies from Hikosaka's research group have indicated that caudate activity that anticipates a memory-guided saccade is sensitive to the contingency between the visual cue and the reward [6,7]. They designed the BST to address how this reward-related activity might be used in the process of generating the saccade.…”

mentioning

confidence: 99%

“…Of the 41 neurons with anticipatory activity, 31 exhibited spatially selective reward anticipation during the BST. Of these 31, 22 were tested on the second task and most, but not all, [7] and a representation of color-reward contingencies [6]. Learning how these different properties are represented across the population of neurons in the caudate will be an essential step in understanding its role in using information related to reward to influence oculomotor behavior.…”

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confidence: 99%

Linking reward expectation to behavior in the basal ganglia

Gold

2003

Trends in Neurosciences

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Psychological factors such as expected reward value can have strong effects on behavior. Although signals related to reward have been found in numerous brain regions, how these signals are used by the circuits that control action is unknown. A recent study suggests that neurons in the caudate nucleus of the basal ganglia could play a role in transforming expected reward into a spatially selective behavioral bias.Poor Paris was asked to make a decision that even Zeus had avoided. Who was the most beautiful goddess: Hera, Athena or Aphrodite? Fearful and uncertain about how his decision would be received by the losers, he triedtactfully but unsuccessfully -to declare a three-way tie. Told to make a decision, Paris received assurances that there would be no reprisals and, even better, was offered rewards by the goddesses to try to influence him. Hera promised that if he picked her, he would become the King of Asia, as well as the richest man alive. Athena promised that Paris would be victorious in all battles, and that he would become the most handsome and wise man in the world. Aphrodite offered, simply, the beautiful Helen of Troy. It was no contest: Aphrodite's reward easily biased Paris' decision in her favor.The fact that 'psychological' factors, including uncertainty and anticipated costs and benefits, biased the judgment of Paris and can affect similarly subjective decisions is to be expected. Perhaps more surprising is that these factors can also shape our ability to perform even mundane sensory-motor tasks, influencing how well and how quickly we perceive sensory stimuli and execute appropriate motor commands [1,2]. However, as central as these influences are to both complex and simple behaviors, little is known about the underlying neural mechanisms. For example, despite a growing body of work identifying neural circuits that represent information related to reward in the context of sensory -motor tasks [3], how these kinds of signals might influence behavior is a mystery. A recent study by Lauwereyns and colleagues has begun to shed light on this difficult issue [4]. The results describe neural signals in a region of the basal ganglia called the caudate nucleus that appear to relate anticipation of an uncertain reward with the preparation for a goal-directed eye movement.Caudate responses correspond to an advance bias In their study, Lauwereyns and colleagues trained monkeys to perform a 'biased saccade task' (BST). On a given trial, the monkey fixated a central spot of light until a target (another spot of light) appeared to the left or to the right. Once the target appeared, the monkey made a saccadic eye movement to it as quickly as possible. Then came the crucial feature of the task: after correctly making the saccade, the monkey was rewarded (with a sound plus a drop of liquid) only if the target was in one of the two possible locations. The rewarded location was fixed in blocks of 20 consecutive trials, such that only correct leftward saccades were rewarded in one block, only correct rightward sacc...

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Romantic love: An fMRI study of a neural mechanism for mate choice

Fisher

Aron

Brown

2005

J of Comparative Neurology

296

172

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Scientists have described myriad traits in mammalian and avian species that evolved to attract mates. But the brain mechanisms by which conspecifics become attracted to these traits is largely unknown. Yet mammals and birds express mate preferences and make mate choices, and data suggest that this "attraction system" is associated with the dopaminergic reward system. It has been proposed that intense romantic love, a cross-cultural universal, is a developed form of this attraction system. To determine the neural mechanisms associated with romantic love we used functional magnetic resonance imaging (fMRI) and studied 17 people who were intensely "in love" (Aron et al. [2005] J Neurophysiol 94:327-337). Activation specific to the beloved occurred in the right ventral tegmental area and right caudate nucleus, dopamine-rich areas associated with mammalian reward and motivation. These and other results suggest that dopaminergic reward pathways contribute to the "general arousal" component of romantic love; romantic love is primarily a motivation system, rather than an emotion; this drive is distinct from the sex drive; romantic love changes across time; and romantic love shares biobehavioral similarities with mammalian attraction. We propose that this attraction mechanism evolved to enable individuals to focus their mating energy on specific others, thereby conserving energy and facilitating mate choice-a primary aspect of reproduction. Last, the corticostriate system, with its potential for combining diverse cortical information with reward signals, is an excellent anatomical substrate for the complex factors contributing to romantic love and mate choice.

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Feature-Based Anticipation of Cues that Predict Reward in Monkey Caudate Nucleus

Cited by 119 publications

References 53 publications

The Neurobiological Foundations of Valuation in Human Decision Making Under Uncertainty

The Neurobiological Foundations of Valuation in Human Decision Making Under Uncertainty

Linking reward expectation to behavior in the basal ganglia

Romantic love: An fMRI study of a neural mechanism for mate choice

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