Feathery Tellurium–Selenium Heterostructural Nanoadjuvant for the Synergistic Treatment of Bacterial Infections

Abstract

Antibacterial nanoagents with well-controlled structures are greatly desired to address the challenges of bacterial infections. In this study, a featherlike tellurium−selenium heterostructural nanoadjuvant (TeSe HNDs) was created. TeSe HNDs produced 1 O 2 and had high photothermal conversion efficiency when stimulated with 808 nm near-infrared (NIR) light. To create a synergistic treatment system (TeSe-ICG) with better photothermal and photodynamic capabilities, the photosensitizer indocyanine green (ICG) was then added. With a bactericidal rate of more than 99%, the NIR-mediated TeSe-ICG demonstrated an efficient bactericidal action against both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). In addition, TeSe-ICG was also effective in treating wound infections and could effectively promote wound healing without obvious toxic side effects. In conclusion, TeSe-ICG is expected to be a good candidate for the treatment of bacterial infections.

NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing

“…As indicated by the X-ray diffraction (XRD) pattern, the respective diffraction bands closely matches the diffraction profile of the chalcogenide family (Fig. 2C ) 31 . The prominent diffraction peak at 28.77° indicates that cetyltrimethylammonium bromide (CTAB) directs the formation of Se-Te NPs on the (101) lattice plane 32 , 33 .…”

Ultrabright NIR-IIb Fluorescence Quantum Dots for Targeted Imaging-Guided Surgery

“…Currently, materials used for NIR fluorescence imaging are mainly organic small molecules . For example, Indocyanine Green (ICG), a Food and Drug Administration (FDA) approved fluorescent small molecule, has been successfully employed for the first time in human liver tumor resection, establishing a reliable foundation for intraoperative NIR-II navigation. However, such kinds of imaging molecules encounter challenges, including poor resistance to photobleaching, limited fluorescence penetration, and the presentation of only surface fluorescence information in biological tissues .…”