Feasibility, validity and reliability of objective smartphone measurements of physical activity and fitness in patients with cancer

Abstract

BackgroundA patient’s physical function plays a leading role in the treatment prescription for patients with cancer. Objective assessments of physical function may be more predictive for treatment tolerability and survival than frequently used subjective measures, such as the Eastern Cooperative Oncology Group/World Health Organization (ECOG/WHO) performance score. The use of smartphones to measure physical activity and fitness may provide an excellent opportunity to objectively estimate a patient’s physical function against low costs and little time. We investigated feasibility, validity and reliability of smartphone measurements of step count and physical fitness in patients with cancer.MethodsIn total, 72 patients participated. They wore a smartphone for 14 days to measure the mean number of steps per day, concomitant with an accelerometer during the first 7 days. Patients performed a six-minute walk test (6MWT) twice outdoors via a smartphone application and once in a test environment in the hospital. Feasibility was evaluated by the proportion of patients who completed the study as well as smartphone assessments of step count and physical fitness. Validity was assessed with the intraclass correlation coefficient (ICC) between the accelerometer and the first week of the smartphone for step count, and between the 6MWT in the hospital and via the application for physical fitness. Test-retest reliability was assessed with the ICC between step count levels of the first and second week of smartphone assessments, and between the first and second six-minute walk test in the home environment.ResultsThe completeness of smartphone measurements was approximately 90% for step count and 64% for physical fitness assessments. Validity was excellent for step count (ICC = 0.97, p < 0.001) and fair for fitness (ICC = 0.47, p < 0.001). We found excellent test-retest reliability for step count (ICC = 0.91, p < 0.001) and physical fitness (ICC = 0.88, p < 0.001).ConclusionsThis study showed that objective smartphone measurements of step count in clinical practice are feasible, valid and reliable. These findings indicate that the use of smartphones to objectively assess physical activity in clinical cancer practice is promising and may be used to select patients for treatment and study participation, to monitor patients during treatment and to guide treatment decisions.

Physical activity in patients with cancer: self-report versus accelerometer assessments

“…For optimal use in clinical practice, it is important to reduce the labor intensity and costs of accelerometers or to search for alternatives for objective physical activity assessments [45]. Widely available smartphones, pedometers, or fitness trackers may provide such alternatives, and have shown to be feasible, and produce valid and reliable step counts in patients with cancer, when compared with accelerometers [46,47].…”

Harnessing consumer smartphone and wearable sensors for clinical cancer research

“…In the past few years, several studies suggest that smartphones may have clinical utility for oncology care. Some of these have focused exclusively on the ability of smartphone accelerometers to estimate step count, reporting that smartphone measurements are valid and reliable 41 . A pilot intervention where chemotherapy patients were given a smartphone with a pedometer application and contacted if their daily step count decreased >15% from baseline was shown to be feasible and to help identify chemotherapy toxicity 42 .…”

Mobilizing Breast Cancer Prevention Research Through Smartphone Apps: A Systematic Review of the Literature

“…Cancer care coordination studies focused on the support and communication between the breast cancer patient and the physician (32, 41, 47, 48, 66, 68), as well as specific aspects of cancer care coordination, such as symptomology (12, 14, 23, 27, 52), medication adherence (23, 34, 38, 45, 66), and ambulatory surgery (7, 8). Research using apps designed to improve health related quality of life focused on general lifestyle management (30, 42, 56, 60, 64, 69), weight management (61, 66, 67), depression and breast cancer related distress (12, 17, 21, 23, 37, 63), social support (12, 40, 50, 51), sleep (20), and physical activity during and after a breast cancer diagnosis (9, 11, 22, 24, 25, 28, 29, 33, 35, 36, 46, 55, 59, 65). The use of mobile apps for tertiary cancer prevention was preferred in contrast to usual standard of care practices.…”