Feasibility study on concentration of slurry and classification of contained particles by microchannel

Ookawara, Shinichi; Higashi, Ryochi; Street, David; Ogawa, Kohei

doi:10.1016/j.cej.2003.11.008

Cited by 95 publications

(71 citation statements)

References 9 publications

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“…A power fit of U Dean,Avg versus Dean number similar to previous scalings was generated with an exponent of approximately 1.4 for all the devices simulated. 33 This plot is available in the supplemental material 34 as well as the calculated power fits. These more accurate values for U Dean,Avg are incorporated into the second approximation of R f defined in Eq.…”

Section: B Ratio Of Forces Threshold For Achieving Quality Focusingmentioning

confidence: 99%

Inertial focusing dynamics in spiral microchannels

2012

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This report details a comprehensive study of inertial focusing dynamics and particle behavior in low aspect ratio (h/w ∼ 1/1 to 1/8) spiral microchannels. A continuum of particle streak behavior is shown with longitudinal, cross-sectional, and velocity resolution, yielding a large analyzed parameter space. The dataset is then summarized and compared to prior results from both straight microchannels and other low aspect ratio spiral microchannel designs. Breakdown of focusing into a primary and secondary fluorescent streak is observed in the lowest aspect ratio channels at high average downstream velocities. Streak movement away from the theoretically predicted near inner wall equilibrium position towards the center of the channel at high average downstream velocities is also detailed as a precursor to breakdown. State diagrams detail the overall performance of each device including values of the required channel lengths and the range of velocities over which quality focusing can be achieved.

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Section: B Ratio Of Forces Threshold For Achieving Quality Focusingmentioning

confidence: 99%

Inertial focusing dynamics in spiral microchannels

2012

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“…130 Different relationships between the velocity of Dean flow and the corresponding Dean number have been put forward. For example, Ookawara et al 131 proposed the following correlation based on the numerical simulations of the problem with a specific configuration…”

Section: Dean Flowmentioning

confidence: 99%

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

2013

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Focusing and sorting cells and particles utilizing microfluidic phenomena have been flourishing areas of development in recent years. These processes are largely beneficial in biomedical applications and fundamental studies of cell biology as they provide cost-effective and point-of-care miniaturized diagnostic devices and rare cell enrichment techniques. Due to inherent problems of isolation methods based on the biomarkers and antigens, separation approaches exploiting physical characteristics of cells of interest, such as size, deformability, and electric and magnetic properties, have gained currency in many medical assays. Here, we present an overview of the cell/particle sorting techniques by harnessing intrinsic hydrodynamic effects in microchannels. Our emphasis is on the underlying fluid dynamical mechanisms causing cross stream migration of objects in shear and vortical flows. We also highlight the advantages and drawbacks of each method in terms of throughput, separation efficiency, and cell viability. Finally, we discuss the future research areas for extending the scope of hydrodynamic mechanisms and exploring new physical directions for microfluidic applications.

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“…Some approaches combine microfluidic flow with a force field, such as electric [11], magnetic [12,13], optical [14], or acoustic [15] fields, or with biochemical interactions (selective lysis or antigenantibody capture). Other approaches are based on passive hydrodynamics in microchannels, for example, microfiltration [16]; pinched-flow fractionation (PFF) and hydrodynamic filtration (HDF) [17,18]; hydrophoresis [19][20][21][22][23][24]; deterministic lateral displacement (DLD) around pillars [25]; and inertial separation in curved channels or spirals [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Continuous Inertial Focusing and Separation of Particles by Shape

et al. 2012

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An effective approach to separating shaped particles is needed to isolate disease-causing cells for diagnostics or to aid in purifying nonspherical particles in applications ranging from food science to drug delivery. However, the separation of shaped particles is generally challenging, since nonspherical particles can freely rotate and present different faces while being sorted. We experimentally and numerically show that inertial fluid-dynamic effects allow for shape-dependent separation of flowing particles. (Spheres and rods with aspect ratios of 3:1 and 5:1 have all been separable.) Particle rotation around a conserved axis following Jeffery orbits is found to be a necessary component in producing different equilibrium positions across the channel that depend on particle rotational diameter. These differences are large enough to enable passive, continuous, high-purity, high-throughput, and shape-based separation downstream. Furthermore, we show that this shape-based separation can be applied to a large range of particle sizes and types, including small, artificially made 3-m particles as well as bioparticles such as yeast. This practical approach for sorting particles by a previously inaccessible geometric parameter opens up a new capability that should find use in a range of fields.

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Feasibility study on concentration of slurry and classification of contained particles by microchannel

Cited by 95 publications

References 9 publications

Inertial focusing dynamics in spiral microchannels

Inertial focusing dynamics in spiral microchannels

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

Continuous Inertial Focusing and Separation of Particles by Shape

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