Feasibility Study of Microneedle Fabrication from a thin Nitinol Wire Using a CW Single-Mode Fiber Laser

Tu, Jay F.; Reeves, Nicolas

doi:10.1515/eng-2019-0023

Cited by 14 publications

(3 citation statements)

References 15 publications

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“…This kind of microneedle does not require any auxiliary tools, such as an impact‐insertion applicator, to operate. Nitinol has been selected by Tu and Reeves [ 80 ] to fabricate hollow MNs because of its excellent super‐elasticity and biocompatibility. And the drilling axial holes were drilled in a nitinol wire with a diameter of 150 µm by using a multiple‐pulse laser micro‐hole drilling technology.…”

Section: Materials and Classification Of Mnsmentioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

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In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

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Section: Materials and Classification Of Mnsmentioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…Adding to the need for intense research toward a low-cost on-patch point of care diagnostic device, first reported using hollow microneedles in 2020. [26] Conventional methods of hollow microneedle fabrication, such as deep reactive ion etching and microhole drilling, [27,28] are time consuming and require the use of expensive specialized equipment. 3D printing is an attractive alternative allowing for easier customization and intricate microneedle architectures otherwise difficult to achieve with alternative industrialscale methods.…”

Section: Introductionmentioning

confidence: 99%

3D‐Printed Hollow Microneedle‐Lateral Flow Devices for Rapid Blood‐Free Detection of C‐Reactive Protein and Procalcitonin

Turner

Lay

Jungwirth

et al. 2023

Adv Materials Technologies

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Hollow microneedle devices as a technology for interstitial fluid extraction show promise for the minimally invasive point‐of‐care detection of analytes. Despite increasing efforts toward on‐patch diagnostics, the use of hollow microneedles has been limited due to the complexity caused by integrating hollow microneedles with established point‐of‐care diagnostic techniques. Herein, a 3D printing method is utilized, to provide low‐cost manufacturing of custom‐designed hollow microneedle devices, allowing for easy integration with lateral flow assays for rapid and blood‐free diagnostics. Microneedle surface modification through PEGylation results in prolonged and enhanced hydrophilicity, enabling passive uptake of small volume samples (≈22.5 µL) and an enhanced shelf life. The hollow microneedle devices are deemed non‐cytotoxic to cell types found within the skin following short‐term and prolonged exposure in accordance with ISO10993. Furthermore, the devices demonstrate high mechanical strength and successfully penetrate porcine skin grafts without damaging the surrounding skin morphology. This work also demonstrates for the first time the use of hollow microneedles for the simultaneous detection, at clinically relevant concentrations, of C‐reactive protein (LoD = 10 µg mL−1) and procalcitonin (LoD = 1 ng mL−1), through porcine skin, ultimately demonstrating the beneficial use of manufactured 3D‐printed hollow microneedles towards low‐cost blood‐free diagnostics of inflammation markers.

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“…The flag-shaped stressstrain relationship also dissipates large amounts of energy during cyclic hysteresis loading through the SME. As a result, new applications have been found in fields such as medicine [4], aerospace, mechanical engineering, and structural engineering.…”

Section: Introductionmentioning

confidence: 99%

Optimization of shape memory alloy braces for concentrically braced steel braced frames

Babaei

Zarfam

2019

Open Engineering

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Expanding the use of smart braced frames to govern the seismic response of structures by providing ductility and elasticity has been hampered and delayed by cost indexes. The braces in frames comprise two segments of expensive shape memory alloys (SMAs) and high-strength steel with high stiffness. These smart materials can reduce seismic damage by providing stiffness, yielding, and phase shifting. In this study, the length of the SMA segments in three- and six-story frames (applied either at all floors or as part of a dual system) was increased to determine the optimal length at a constant period. Performance levels and fragility curves were obtained to evaluate the seismic behavior of the optimized frame. The response modification factor determined based on the static pushover, incremental nonlinear dynamic analysis, and linear dynamic analysis suggests the ductility and over-strength of the optimized frame. The probability of being in or exceeding each damage state was determined with a Monte Carlo analysis and was acceptable and in accordance with previous deterministic analysis results.

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Feasibility Study of Microneedle Fabrication from a thin Nitinol Wire Using a CW Single-Mode Fiber Laser

Cited by 14 publications

References 15 publications

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

3D‐Printed Hollow Microneedle‐Lateral Flow Devices for Rapid Blood‐Free Detection of C‐Reactive Protein and Procalcitonin

Optimization of shape memory alloy braces for concentrically braced steel braced frames

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