Feasibility Study of Dielectrical Field-Flow Fractionation

Davis, Joe M.; Giddings, J. Calvin

doi:10.1080/01496398608058390

Cited by 35 publications

(16 citation statements)

References 35 publications

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“…Little advantage is expected for dielectrical FFF (n = 3), however, because pearl-chain formation is expected to limit extensively inner-wall retention (19 limitation, although this subject has not been eamined in detail. Smaller advantages are anticipated for electrical, thermal, and flow FFF (n = 1) and sedimentation FFF (n = -l), but such advantages are realizable by judicious design of the ANNC and control over the experimental conditions.…”

Section: Theorymentioning

confidence: 96%

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Nonequilibrium Theory for Field-Flow Fractionation in Annular Channels

Davis

1989

Separation Science and Technology

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AbStfactThe principles of field-flow fractionation (FFF) and reasons for extending the FFF methodology from parallel-plate channels to annular channels (ANNCs) are briefly reviewed. A theory for the nonequilibrium plate height H of FFF zones in ANNCs is developed by extending the nonequilibrium theory of FFF to polar coordinates. The principal assumption in the theory is that component zones are localized near the ANNC walls by the general force F =Ah", where A and n are constants and r is the radial coordinate. Equations for H are developed as functions of n, the inner-to-outer radius ratio of the ANNC, and the fundamental FFF parameter, h A closed-form analytical solution to H is obtained when n = 1; the n # 1 solution must generally be expressed as a ratio of the integrals involved. These integrals can be approximated analytically, however, when 1 < 1.The functions for H are compared to their parallel-plate counterpart, and differences are rationalized.

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Section: Theorymentioning

confidence: 96%

“…(15) into N,* = 0 (Z3). Equation (19) states that mass is conserved along the radial coordinate, i.e., that (c) = (c*) (13).…”

Section: Theorymentioning

confidence: 99%

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Nonequilibrium Theory for Field-Flow Fractionation in Annular Channels

Davis

1989

Separation Science and Technology

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“…A much smaller electrical fields used in EIFFF do significantly reduce the damage to biomolecules. The other FFF techniques also include magnetic FFF (MgFFF) (Vickrey and Garcia-Ramirez 1980;Schunk et al 1984), which can separate particles with different magnetic properties by the use of magnetic field; and dielectric FFF (DIFFF) taking advantage of dielectrophoresis (DEP) force on a polarable particle in a non-uniform electric field for separation purposes (Davis and Giddings 1986;Huang et al 1997). Other forces such as photophoretic (Kononenko 2005), concentration gradient (Giddings et al 1977), acoustical (Semenov and Maslow 1988), shear field (Giddings and Brantley 1984), or multiple fields are also being adapted to achieve various particle separation.…”

Section: Introductionmentioning

confidence: 99%

Modeling of micro/nano particle separation in microchannels with field-flow fractionation

et al. 2010

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The cyclical electrical field-flow fractionation (CyElFFF) is a very promising separation technique for particles and biological molecules such as proteins, nucleic acids, viruses, bacteria, yeast cells, mammalian cells. But a clear understanding of the mechanism and performance prediction of this system under different operating parameters is far from completed. This research focuses on a computational investigation of particle behavior in a CyElFFF system by taking into account both electrokinetic effects and particle dynamics. The model was validated with both theory and experimental results. The effects of key parameters such as applied electric field strength and frequency, solution fluid flow rate, particle size, particle shape on separation process are addressed in a systematic way. The developed model can also be utilized in studying the behavior of spherical or non-spherical particles (such as nanowire, nanorod, and nanofiber) in other microfluidic systems.

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“…By optimizing chip layout and field parameters it is possible to separate similar cellular components in high conductive media using DEP [10,11]. For contact-less transport [12][13][14] and sorting abilities [15] Dielectrophoresis Field-Flow Fractionation (DEP-FFF) can be used without any microfluidics. For further miniaturization, reduction of costly chemicals, more efficient analyzing process and increasing sensivity processing on a single cell level (DNA) is a task for further biochip technology development.…”

Section: Introductionmentioning

confidence: 99%

Integration of DNA molecules in microelectronic environment using dielectrophoresis

et al. 2009

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The connection of biomolecules like DNA to a micro scale environment such as microarrays and Lab-on-a-chip systems is an imminent task in biochip technology. Especially in Lab-on-a-chip systems microscopic forces are used to separate the analyte from a complex mixture for further analysis [1]. In this contribution the sorting and manipulation of DNA using dielectrophoresis (DEP) on micro structured chips was investigated [2]. DEP represents an interesting approach to manipulate and control objects at the micro-[3, 4] and nanoscale range [5][6][7], and especially to position them at controlled locations in microelectrode arrangements. It could be shown that DNA can be reversible arranged but also permanently immobilized in micro scale electrode gaps. It was also demonstrated that it is possible to stretch and align DNA from a single molecule level to high DNA concentration in a parallel manner between microelectrodes [8]. Furthermore DNA was stretched between moveable electrodes.

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Feasibility Study of Dielectrical Field-Flow Fractionation

Cited by 35 publications

References 35 publications

Nonequilibrium Theory for Field-Flow Fractionation in Annular Channels

Nonequilibrium Theory for Field-Flow Fractionation in Annular Channels

Modeling of micro/nano particle separation in microchannels with field-flow fractionation

Integration of DNA molecules in microelectronic environment using dielectrophoresis

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