Feasibility study for remote assessment of cognitive function in multiple sclerosis

George, Michaela F.; Holingue, Calliope; Briggs, Farren; Shao, Xiaorong; Bellesis, Kalliope H; Whitmer, Rachel A.; Schaefer, Catherine; Benedict, Ralph H. B.; Barcellos, Lisa F.

doi:10.29245/2572.942x/2016/8.1084

Cited by 18 publications

(8 citation statements)

References 38 publications

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“…We showed that remote cognitive assessment of patients with hematological cancers is feasible and provides several advantages including efficiency, convenience, and automated scoring. This is consistent with previous studies supporting the feasibility of remotely measuring cognitive performance in other populations 19,28 . Additionally, although for this pilot study we restricted enrollment to English‐speaking participants, BrainCheck can be administered in multiple languages.…”

Section: Discussionsupporting

confidence: 89%

“…This is consistent with previous studies supporting the feasibility of remotely measuring cognitive performance in other populations. 19 , 28 Additionally, although for this pilot study we restricted enrollment to English‐speaking participants, BrainCheck can be administered in multiple languages. However, there are also several caveats to remote assessment.…”

Section: Discussionmentioning

confidence: 99%

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Remote assessment of cognitive dysfunction in hematologic malignancies using web‐based neuropsychological testing

et al. 2022

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Remote assessment of cognitive dysfunction in hematologic malignancies using web‐based neuropsychological testing

et al. 2022

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“…Depression was assessed as previously described. 29 Age at MS onset was confirmed by review of EHR. For each participant, we calculated the Multiple Sclerosis Severity Scale (MSSS), an indicator of disease severity using the Expanded Disability Status Scale and disease duration.…”

Section: Clinical Datamentioning

confidence: 89%

Cross-Trait Mendelian Randomization Study to Investigate Whether Migraine Is a Risk Factor for Multiple Sclerosis

et al. 2023

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Background and Objectives:Migraine is common among people with multiple sclerosis (MS), but the reasons for this are unknown. We tested three hypothesized mechanisms for this observed comorbidity, including migraine is a risk factor for MS, genetic variants are shared between the conditions, and migraine is a result of MS.Methods:Data were from two sources: publicly available summary statistics from genome-wide association studies of MS (N=115,748) and migraine (N=375,752 and N=361,141), and a case-control study of MS recruited from the Kaiser Permanente Northern California Health Plan (N=1,991). For the latter participants, migraine status was ascertained using a validated electronic health record migraine probability algorithm or self-report. Using the public summary statistics, we used two-sample Mendelian randomization to test whether a migraine genetic instrumental variable was associated with MS. We used linkage disequilibrium score regression and LOGODetect to ascertain whether MS and migraine shared genetic variants across the genome and regionally. Using the Northern California MS cohort, we used logistic regression to identify whether people with both MS and migraine had different odds of clinical characteristics (e.g., age at MS onset, Perceived Deficits Questionnaire, depression) or MS-specific risk factors (e.g., body mass index, smoking status, infectious mononucleosis status) compared to people with MS without migraine.¬¬Results:We did not find evidence supporting migraine as a causal risk factor for MS (p=0.29). We did, however, identify four major histocompatibility complex (MHC) loci shared between MS and migraine. Among the Northern California MS cohort, 774 (39%) experienced a migraine. People with both MS and migraine from this cohort were more likely to ever smoke (odds ratio (OR)=1.30, 95% confidence interval (CI): 1.08, 1.57), have worse self-reported cognitive deficits (OR=1.04, 95% CI: 1.02, 1.06), and ever experience depression (OR=1.48, 95% CI: 1.22, 1.80).Discussion:Our findings do not support migraine as a causal risk factor for MS. Several genetic variants, particularly in the MHC, may account for some of the overlap. It seems likely that migraine within the context of MS is a result of MS. Identifying what increases risk of migraine within MS might lead to improved treatment and quality of life.

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“…The aspects evaluated include therapeutic follow-up, remote assessment of functional status, use of technologies to aid in rehabilitation (telerehabilitation), remote neurocognitive assessment, remote psychological interventions, including cognitive-behavioral therapy, mindfulness, and neuropsychological rehabilitation, remote monitoring of activities, and assessment of adherence to medical therapy 19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35 .…”

Section: Multiple Sclerosismentioning

confidence: 99%

“…Telemedicine was tested for neuropsychological and mental health assessment in MS patients 32 . Another study assessed the use of digital tools for neuropsychological rehabilitation in patients with MS 35 . These studies showed positive contributions of the use of technology both for the evaluation and for rehabilitation of these patients 32,35 .…”

Section: Multiple Sclerosismentioning

confidence: 99%

Telemedicine in neurology: current evidence

Domingues¹,

Mantese²,

Aquino

et al. 2020

Arq. Neuro-Psiquiatr.

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Background: Telemedicine was first introduced in Neurology as a tool to facilitate access to acute stroke treatment. More recently, evidence has emerged of the use of telemedicine in several other areas of Neurology. With the advent of the COVID-19 pandemic and the need for social isolation, Brazilian authorities have expanded the regulation of the use of telemedicine, thus allowing the treatment of many patients with neurological diseases to be conducted with less risk of SARS-CoV-2 contamination. Objective: This study aimed to critically review the current evidence of the use, efficacy, safety, and usefulness of telemedicine in Neurology. Methods: A review of PubMed indexed articles was carried out by searching for the terms “telemedicine AND”: “headache”, “multiple sclerosis”, “vestibular disorders”, “cerebrovascular diseases”, “epilepsy”, “neuromuscular diseases”, “dementia”, and “movement disorders”. The more relevant studies in each of these areas were critically analyzed. Results: Several articles were found and analyzed in each of these areas of Neurology. The main described contributions of telemedicine in the diagnosis and treatment of such neurological conditions were presented, indicating a great potential of use of this type of assistance in all these fields. Conclusion: Current evidence supports that teleneurology can be a tool to increase care for patients suffering from neurological diseases.

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Feasibility study for remote assessment of cognitive function in multiple sclerosis

Cited by 18 publications

References 38 publications

Remote assessment of cognitive dysfunction in hematologic malignancies using web‐based neuropsychological testing

Remote assessment of cognitive dysfunction in hematologic malignancies using web‐based neuropsychological testing

Cross-Trait Mendelian Randomization Study to Investigate Whether Migraine Is a Risk Factor for Multiple Sclerosis

Telemedicine in neurology: current evidence

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