Feasibility, Reliability and Predictive Value Of In-Ambulance Heart Rate Variability Registration

Yperzeele, Laetitia; Hooff, Robbert-Jan Van; Smedt, Ann De; Nagels, Guy; Hubloue, Ives; Keyser, Jacques De; Brouns, Raf

doi:10.1371/journal.pone.0154834

Cited by 11 publications

(25 citation statements)

References 24 publications

(33 reference statements)

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“…A non-invasive two-lead ECG registration (eMotion HRV, Motion Ltd., Kuopio, Finland) in supine position at rest, was performed at baseline (all MS and HC participants) and three months later (MS and HC recruited in the NMSC) for 10 min (1000 Hz sampling frequency). Kubios HRV 2.1 software (Department of Applied Physics, University of Eastern Finland, Kuopio, Finland) was used to select the middle 5 min interval (2 30" to 7 30"), followed by ectopic interval detection (4th order filter) with cubic spline interpolation and de-trending with Wavelet Packet in HRVAS software [18] as in [31]. The batch processing function allowed a blinded analysis.…”

Section: Methodsmentioning

confidence: 99%

Relation between Heart Rate Variability and Disease Course in Multiple Sclerosis

Reynders

Gidron

Ville

et al. 2019

JCM

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Little is known about the interplay between the autonomic nervous system and disease activity in multiple sclerosis (MS). We examined the relationship between heart rate variability (HRV), a reliable measure of vagal nerve function, and disease characteristics in a prospective MS cohort. Standard deviation of each normal-to-normal inter-beat interval (SDNN) and root mean square of successive differences (RMSSD), global indices of HRV, were measured in 114 MS patients, which included four predefined subgroups, and 30 age and sex-matched healthy controls (HC). We assessed group differences at baseline, HRV reproducibility at month 3, and used logistic regression modeling to relate baseline HRV with relapse occurrence. No significant HRV differences were found between MS and HC and between MS subgroups. In MS patients, both HRV indices correlated with age (r = −0.278, p = 0.018 and r = −0.319, p < 0.001, respectively) and with month 3 assessments (r = 0.695 and r = 0.760, p < 0.001). Higher SDNN and RMSSD at baseline were associated with self-reported relapses at month 3 (OR = 1.053, 95% CI (1.013–1.095), p = 0.009 and OR = 1.065, 95% CI (1.016–1.117), p = 0.009), and SDNN at baseline with relapses at month 12 (OR = 1.034, 95% CI (1.009–1.059), p = 0.008; ROC, AUC = 0.733, p = 0.002). There were no baseline HRV differences between MS and HC or between subgroups. Post-hoc analysis showed an association with an increased relapse risk.

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Section: Methodsmentioning

confidence: 99%

Relation between Heart Rate Variability and Disease Course in Multiple Sclerosis

Reynders

Gidron

Ville

et al. 2019

JCM

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“…Power spectral analysis describes the periodic oscillations of the heart rate decomposed at different frequencies and amplitudes by Fast Fourier Transformation [31], with regard to oscillations in cardiovascular parameters. The HF component (0.15-0.4 Hz) is considered to indicate vagal influence over the heart, while the LF component (0.04-0.15 Hz) is believed to reflect both sympathetic and vagal influence and has been correlated with baroreflex sensitivity [25,28].…”

Section: Frequency Domainmentioning

confidence: 99%

“…The LF/HF ratio is an index for overall sympatho-vagal balance. A ratio greater than one is an estimate of sympathetic dominance, while a LF/HF ratio less than one is associated with parasympathetic dominance [22,31,32]. Time Domain Analysis (SDNN, RMSSD, pNN50) A total of four studies provided analyzable data for time domain analysis of HRV (SDNN, RMSSD, and pNN50) with 384 patients.…”

Section: Frequency Domainmentioning

confidence: 99%

Heart Rate Variability and Cardiopulmonary Dysfunction in Patients with Duchenne Muscular Dystrophy: A Systematic Review

et al. 2018

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Duchenne muscular dystrophy (DMD) is a genetic recessive disorder with progressive muscle weakness. Despite the general muscle wasting, degeneration and necrosis of cardiomyocytes have been the main causes of morbidity and death in individuals with DMD. Cardiac failure is generally preceded by disturbances in heart rate variability (HRV), and non-invasive measurement of the autonomic nervous system has been an important tool to predict adverse cardiovascular events. Hence, the application of HRV to study autonomic modulation in DMD individuals, and the establishment of correlations between HRV and heart/lung diseases, age, and mortality will have the potential to improve quality of life and life expectancy of individuals with DMD. In order to evaluate the state of the art in this field, we conducted a systematic search in Medline/PubMed and BVS (virtual library in health) databases. We selected 8 studies using pre-defined criteria and meta-analysis revealed decreased parasympathetic activity and increased sympathetic predominance in individuals with DMD as major observations. Moreover, there is a strong association between diminished HRV and myocardial fibrosis with DMD. These patterns are evident in patients at early-stage DMD and become more prominent as disease severity and age increase. Thus, data minning clearly indicates that HRV assessment can be used as a predictor for sudden death in individuals with DMD. The use of the HRV, which is inexpensive, ubiquitously available in clinics and hospitals, and a non-invasive analysis tool, can save lives and decrease the morbity in DMD by alerting care givers to consider autonomic nervous system intervention.

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“…Recordings were visualized and processed using HRV Analysis Software (HRVAS). For each condition an artefact-free segment with a duration of 5 minutes was chosen for the analysis, in order to correct for noise or extrabeats, etc (22).…”

Section: Hrv and Cbfmentioning

confidence: 99%

Cerebral Blood Flow and Heart Rate Variability in Chronic Fatigue Syndrome: A Randomized Cross-Over Study

Malfliet¹,

Pas

Brouns

et al. 2018

Pain Phys

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Background: Pain, fatigue, and concentration difficulties are typical features of chronic fatigue syndrome (CFS). The exact underlying mechanisms of these symptoms are still unknown, but available evidence suggests an important role for impaired pain modulation. As evidence also suggests that pain modulation is related to cardiovascular mechanisms, it seems logical to investigate whether cerebral blood flow (CBF) and heart rate variability (HRV) are altered in these patients. Objectives: We aimed to investigate the role of the cardiovascular system in pain modulation and symptoms of CFS; the response of CBF and HRV to physical stress and their relation to the change in temporal summation (TS) of pressure pain and selfreported symptoms was evaluated. Study Design: A controlled, randomized cross-over trial. Setting: University Hospital Brussels. Methods: Twenty CFS patients and 20 sedentary healthy controls were included in this study. In both of the groups, the change in TS of pressure pain, CBF (using transcranial Doppler), and HRV (using finger plethysmography) was examined during physical and emotional stress (to control for potential bias), as well as their association mutually and with self-reported symptoms of pain, fatigue, and concentrations difficulties. Results: There was no significant interaction or group (F-values ranging from .100 to 1.862, P-values ranging from .754 to .181) effect in CBF or HRV parameters. HRV and CBF did change during physical exercise, but the changes did not differ between patients and controls. While pain scores during TS at the trapezius site reduced in the control group after the physical exercise protocol (P = .037), they did not change in the CFS group (P = .108), suggesting impaired pain modulation. There were no significant correlations between CBF, HRV, TS, and self-reported symptoms (all P-values of correlation analyses > .01). Limitations: Although effect sizes were medium to large, the study sample was relatively low. Also, the mild nature of the exercise bout is discussable. Nonetheless, this mild exercise was able to provoke endogenous pain modulation in the control group, which endorsed a proper execution of the cycling exercise. Moreover, mild exercises are more applicable to daily physical activities in CFS patients than vigorous exercises. Conclusion: These results seem to refute the previously suggested alterations of CBF/ HRV in CFS patients. These cardiovascular parameters appear not to explain pain before, during, and following exercise. Key words: Chronic pain, physical exercise, emotional stress, pain modulation, cardiovascular systems, temporal summation, pain pressure thresholds, transcranial Doppler, plethysmography

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Feasibility, Reliability and Predictive Value Of In-Ambulance Heart Rate Variability Registration

Cited by 11 publications

References 24 publications

Relation between Heart Rate Variability and Disease Course in Multiple Sclerosis

Relation between Heart Rate Variability and Disease Course in Multiple Sclerosis

Heart Rate Variability and Cardiopulmonary Dysfunction in Patients with Duchenne Muscular Dystrophy: A Systematic Review

Cerebral Blood Flow and Heart Rate Variability in Chronic Fatigue Syndrome: A Randomized Cross-Over Study

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