Feasibility of Video Capsule Endoscopy in the Management of Children With Peutz‐Jeghers Syndrome: A Blinded Comparison With Barium Enterography for the Detection of Small Bowel Polyps

Postgate, Aymer; Hyer, Warren; Phillips, R. K. S.; Gupta, Arun; Burling, David; Bartram, Clive I.; Marshall, Michelle; Taylor, Stuart A.; Brown, Gregor J.; Schofield, Gill; Bassett, Paul; Spray, Christine; Fitzpatrick, Aine; Fraser, Chris; Latchford, Andrew

doi:10.1097/mpg.0b013e31818f0a1f

Cited by 60 publications

(35 citation statements)

References 30 publications

(76 reference statements)

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“…Two studies in adult patients found that video capsule endoscopy (VCE) has a greater sensitivity in detecting small bowel polyps [33,34], although the study size was small in both studies. A prospective study has been performed comparing BaFT and VCE in paediatric patients with PJS [35]. No significant difference was found in detection rates of polyps [1 cm but VCE detected more polyps \1 cm and also was much better tolerated.…”

Section: Mode Of Surveillancementioning

confidence: 95%

Gastrointestinal polyps and cancer in Peutz-Jeghers syndrome: clinical aspects

Latchford

Phillips

2011

Familial Cancer

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The two main problems in the management of the gastrointestinal tract in patients with Peutz-Jeghers syndrome (PJS) are the long term cancer risk and managing polyp related complications, such as intussusception and bleeding. In this article we will focus mainly on the clinical management of these problems. We will highlight some of the controversies regarding gastrointestinal PJS polyps, cancer development and cancer risk. We will review the available literature, particularly focusing on clinical data, to provide insights into these controversies. We describe guidelines for the surveillance and management of gastrointestinal polyps in PJS and review the data behind current recommendations.

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Section: Mode Of Surveillancementioning

confidence: 95%

Gastrointestinal polyps and cancer in Peutz-Jeghers syndrome: clinical aspects

Latchford

Phillips

2011

Familial Cancer

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“…Capsule enteroscopy is a feasible, safe and sensitive test for small bowel surveillance in patients with PJS, even in children. It is significantly more comfortable than barium enterography [86,87] . The use of capsule endoscopy permits earlier diagnosis, therefore, the clinical course of intestinal polyps has changed.…”

Section: Screeningmentioning

confidence: 99%

Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach

Kopáčová

Tachecí²,

Rejchrt³

et al. 2009

WJG

193

183

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Peutz-Jeghers syndrome (PJS) is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280 000 individuals. PJS predisposes sufferers to various malignancies (gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors). Bleeding, obstruction and intussusception are common complications in patients with PJS. Double balloon enteroscopy (DBE) allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome. Prophylaxis and polypectomy of the entire small bowel is the gold standard in PJS patients. Intraoperative enteroscopy (IOE) was the only possibility for endoscopic treatment of patients with PJS before the DBE era. Both DBE and IOE facilitate exploration and treatment of the small intestine. DBE is less invasive and more convenient for the patient. Both procedures are generally safe and useful. An overall recommendation for PJS patients includes not only gastrointestinal multiple polyp resolution, but also regular lifelong cancer screening (colonoscopy, upper endoscopy, computed tomography, magnetic resonance imaging or ultrasound of the pancreas, chest X-ray, mammography and pelvic examination with ultrasound in women, and testicular examination in men). Although the incidence of PJS is low, it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients, and to perform presymptomatic testing in the first-degree relatives of PJS patients.

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“…In specialized centers, CE is used to identify large polyps and to apply BE to remove them. 27,28 The effect on the incidence of intussusceptions remains to be established in prospective trials, though. 29 Adenoma or adenocarcinoma were observed in 9 of 30 polyps (30.0%) > 20 mm and in 1 of 80 polyps (1.3%) ≤20 mm and were resected endoscopically.…”

Section: Endoscopic Resection Of Small Intestinal Polyps Stricture Dmentioning

confidence: 99%

Interventional balloon-enteroscopy

Albert¹

2012

jig

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Feasibility of Video Capsule Endoscopy in the Management of Children With Peutz‐Jeghers Syndrome: A Blinded Comparison With Barium Enterography for the Detection of Small Bowel Polyps

Cited by 60 publications

References 30 publications

Gastrointestinal polyps and cancer in Peutz-Jeghers syndrome: clinical aspects

Gastrointestinal polyps and cancer in Peutz-Jeghers syndrome: clinical aspects

Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach

Interventional balloon-enteroscopy

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