Feasibility of using intermediate x‐ray energies for highly conformal extracranial radiotherapy

Dong, Peng; Yu, Victoria; Nguyen, Dan; DeMarco, John J.; Woods, Kaley; Boucher, S.; Low, Daniel A.; Sheng, Ke

doi:10.1118/1.4868464

Cited by 11 publications

(17 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed radiosensitizing effect comes from increased fraction of low energy electrons (photoelectrons and Auger electrons) at the vicinity of gold nanoparticles4243. Therefore, this multi-scale modeling approach will be very useful for understanding the potential influence on biological effects of investigations involving energy spectrum alteration, such as low-Z target switching technique in the gold nanoparticle radiotherapy44 or the applications of lower MV photon beams in therapy or imaging fields4045.…”

Section: Discussionmentioning

confidence: 99%

An Expanded Multi-scale Monte Carlo Simulation Method for Personalized Radiobiological Effect Estimation in Radiotherapy: a feasibility study

Zhang

Feng

Wang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

A novel and versatile “bottom-up” approach is developed to estimate the radiobiological effect of clinic radiotherapy. The model consists of multi-scale Monte Carlo simulations from organ to cell levels. At cellular level, accumulated damages are computed using a spectrum-based accumulation algorithm and predefined cellular damage database. The damage repair mechanism is modeled by an expanded reaction-rate two-lesion kinetic model, which were calibrated through replicating a radiobiological experiment. Multi-scale modeling is then performed on a lung cancer patient under conventional fractionated irradiation. The cell killing effects of two representative voxels (isocenter and peripheral voxel of the tumor) are computed and compared. At microscopic level, the nucleus dose and damage yields vary among all nucleuses within the voxels. Slightly larger percentage of cDSB yield is observed for the peripheral voxel (55.0%) compared to the isocenter one (52.5%). For isocenter voxel, survival fraction increase monotonically at reduced oxygen environment. Under an extreme anoxic condition (0.001%), survival fraction is calculated to be 80% and the hypoxia reduction factor reaches a maximum value of 2.24. In conclusion, with biological-related variations, the proposed multi-scale approach is more versatile than the existing approaches for evaluating personalized radiobiological effects in radiotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

An Expanded Multi-scale Monte Carlo Simulation Method for Personalized Radiobiological Effect Estimation in Radiotherapy: a feasibility study

Zhang

Feng

Wang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Aperture statistics for the RAO and DMS methods for the seven cases. has far fewer and thicker moving leaves than the conventional MLC, allowing it to be further miniaturized to for compact Linac head designs 24 and small animal irradiators. An effective way to reduce the Linac head size is by moving the beam intensity modulator closer to the X-ray source.…”

Section: Discussionmentioning

confidence: 99%

A novel software and conceptual design of the hardware platform for intensity modulated radiation therapy

et al. 2016

Self Cite

View full text Add to dashboard Cite

The DAO and dose domain optimization approach enabled high quality IMRT plans using a low-complexity collimator setup. The dosimetric quality is comparable or slightly superior to conventional MLC-based IMRT plans using the same number of delivery segments. The SOC IMRT delivery efficiency can be significantly improved by increasing the leaf numbers, but the number is still significantly lower than the number of leaves in a typical MLC.

show abstract

“…The column generation approach was successfully retooled for noncoplanar beam angle selection. [3][4][5][6]29,30 The advantage of column generation, besides being efficient to solve large scale optimization problems, is to be able to integrate fluence optimization into the triplet selection. Instead of relying on human operators to select the triplet orientations, the computerized beam orientation identified optimal triplets that may seem unintuitive to human operators.…”

Section: Discussionmentioning

confidence: 99%

Computerized triplet beam orientation optimization for MRI‐guided Co‐60 radiotherapy

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

Feasibility of using intermediate x‐ray energies for highly conformal extracranial radiotherapy

Abstract: The authors showed the feasibility of using flattening filter free 2 MV x-rays for extracranial treatments as evidenced by equivalent or superior dosimetry compared to 6 MV plans using the same inverse noncoplanar intensity modulated planning method.

Cited by 11 publications

References 51 publications

An Expanded Multi-scale Monte Carlo Simulation Method for Personalized Radiobiological Effect Estimation in Radiotherapy: a feasibility study

An Expanded Multi-scale Monte Carlo Simulation Method for Personalized Radiobiological Effect Estimation in Radiotherapy: a feasibility study

A novel software and conceptual design of the hardware platform for intensity modulated radiation therapy

Computerized triplet beam orientation optimization for MRI‐guided Co‐60 radiotherapy

Contact Info

Product

Resources

About