Feasibility of Ultrasound-guided Percutaneous Samplings in the Pregnant Baboon: A Model for Studies on Transplacental Transport

Calsteren, Kristel Van; Devlieger, Roland; Catte, Luc De; D’Hooghe, Thomas; Chai, Daniel; Mwenda, Jason M.; Vergote, Ignace; Amant, Frédéric

doi:10.1177/1933719108324890

Cited by 6 publications

(5 citation statements)

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“…43 Alternatively phylogenetically more closely related animals like nonhuman primates could be used to test transplacental drug transfer. 46 We can conclude that the transplacental maternofetal transfer of different drugs tested in this mouse model varied widely, with high transfer for carboplatin, intermediate transfer for cytarabine, and limited transfer for anthracyclines and vinblastin. Paclitaxel could not be measured in the fetal plasma.…”

Section: Discussionmentioning

confidence: 75%

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Substantial Variation in Transplacental Transfer of Chemotherapeutic Agents in a Mouse Model

et al. 2011

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Section: Discussionmentioning

confidence: 75%

“…43 Alternatively phylogenetically more closely related animals like nonhuman primates could be used to test transplacental drug transfer. 46…”

Section: Discussionmentioning

confidence: 99%

Substantial Variation in Transplacental Transfer of Chemotherapeutic Agents in a Mouse Model

et al. 2011

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“…Several in vivo and in vitro models have been developed to study the role of endometrial-peritoneal interactions. The baboon has been proposed as an in vivo model to study endometrial-peritoneal implantation [64] . In vitro , potential interactions have been also studied [65] , [66] , but conclusions are controversial.…”

Section: Discussionmentioning

confidence: 99%

Macrophage Migration Inhibitory Factor Is Involved in Ectopic Endometrial Tissue Growth and Peritoneal-Endometrial Tissue Interaction In Vivo: A Plausible Link to Endometriosis Development

et al. 2014

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Pelvic inflammation is a hallmark of endometriosis pathogenesis and a major cause of the disease's symptoms. Abnormal immune and inflammatory changes may not only contribute to endometriosis-major symptoms, but also contribute to ectopic endometrial tissue growth and endometriosis development. A major pro-inflammatory factors found elevated in peritoneal fluid of women with endometriosis and to be overexpressed in peritoneal fluid macrophages and active, highly vascularized and early stage endometriotic lesions, macrophage migration inhibitory factor (MIF) appeared to induce angiogenic and inflammatory and estrogen producing phenotypes in endometriotic cells in vitro and to be a possible therapeutic target in vivo. Using a mouse model where MIF-knock out (KO) mice received intra-peritoneal injection of endometrial tissue from MIF-KO or syngeneic wild type (WT) mice and vice versa, our current study revealed that MIF genetic depletion resulted in a marked reduction ectopic endometrial tissue growth, a disrupted tissue structure and a significant down regulation of the expression of major inflammatory (cyclooxygenease-2), cell adhesion (αv and β3 integrins), survival (B-cell lymphoma-2) and angiogenic (vascular endothelial cell growth) factorsrelevant to endometriosis pathogenesis, whereas MIF add-back to MIF-KO mice significantly restored endometriosis-like lesions number and size. Interestingly, cross-experiments revealed that MIF presence in both endometrial and peritoneal host tissues is required for ectopic endometrial tissue growth and pointed to its involvement in endometrial-peritoneal interactions. This study provides compelling evidence for the role of MIF in endometriosis development and its possible interest for a targeted treatment of endometriosis.

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“…Thus, if primate models are necessary, members of Old World monkeys such as rhesus macaques or baboons may represent appropriate alternatives. It has been proven for placental circulation, gas exchange, endocrinology and immunological as well as to model in parts aspects of pregnancy hypertension or other defects [253][254][255][256][257][258][259]. However, their shallow trophoblast invasion limited the usability as model species for preeclampsia [71].…”

Section: Euarchontogliresmentioning

confidence: 99%

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Mess

2014

Advances in Biology

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Here a survey of placental evolution is conducted. Placentation is a key factor for the evolution of placental mammals that had evolved an astonishing diversity. As a temporary organ that does not allow easy access, it is still not well understood. The lack of data also is a restriction for better understanding of placental development, structure, and function in the human. Animal models are essential, because experimental access to the human placenta is naturally restricted. However, there is not a single ideal model that is entirely similar to humans. It is particularly important to establish other models than the mouse, which is characterised by a short gestation period and poorly developed neonates that may provide insights only for early human pregnancy. In conclusion, current evolutionary studies have contributed essentially to providing a pool of experimental models for recent and future approaches that may also meet the requirements of a long gestation period and advanced developmental status of the newborn in the human. Suitability and limitations of taxa as alternative animal models are discussed. However, further investigations especially in wildlife taxa should be conducted in order to learn more about the full evolutionary plasticity of the placenta system.

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Feasibility of Ultrasound-guided Percutaneous Samplings in the Pregnant Baboon: A Model for Studies on Transplacental Transport

Abstract: Percutaneous amniocentesis and cordocentesis can be performed with a high success rate in the pregnant baboon model. In combination with a 100% success rate in obtaining simultaneous maternal blood samples, this method is able to provide data on transplacental transport.

Cited by 6 publications

References 18 publications

Substantial Variation in Transplacental Transfer of Chemotherapeutic Agents in a Mouse Model

Substantial Variation in Transplacental Transfer of Chemotherapeutic Agents in a Mouse Model

Macrophage Migration Inhibitory Factor Is Involved in Ectopic Endometrial Tissue Growth and Peritoneal-Endometrial Tissue Interaction In Vivo: A Plausible Link to Endometriosis Development

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

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