Feasibility of ultrashort echo time (UTE) T2* cartilage mapping in the hip: a pilot study

Wong, Tony T.; Quarterman, Patrick; Lynch, T. Sean; Rasiej, Michael J.; Jaramillo, Diego; Jambawalikar, Sachin

doi:10.1177/02841851211011563

Cited by 6 publications

(7 citation statements)

References 29 publications

(41 reference statements)

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“…The mean UTE T2* values in the hip cartilage of our asymptomatic patients were similar to those seen in asymptomatic knees by Titchenal et al (16). They were, however, lower than what was found in the hips of their asymptomatic volunteers (12). These differences may be related to technical factors, including the specific scanner used and variation in the parameters of the UTE T2* mapping technique.…”

Section: Discussionsupporting

confidence: 77%

“…UTE T2* mapping is a technique that can potentially be used to assess hip cartilage in patients with FAI. The prior establishment of high inter- and intra-observer variability is helpful for consideration of adaptation of the technique and the reproducibility shown in this study further supports that as a possibility (12). Agergaard et al recently performed a study that also demonstrated high reproducibility of their UTE T2* technique (13).…”

Section: Discussionsupporting

confidence: 74%

“…Automated mean UTE T2* data were generated for each ROI. This segmentation technique was previously shown to have high intra- and inter-observer reliability (12).…”

Section: Methodsmentioning

confidence: 99%

“…Most of the existing studies on UTE T2* have been performed in the knee where alteration in the cartilage matrix has been demonstrated in patients after anterior cruciate ligament injury (11). While feasibility of the technique has been shown in the hip, there have been limited applications of it in patients with FAI (12). Similarly, while reproducibility has been recently shown in the evaluation of patellar tendons, the data in the hip have also been lacking (13).…”

Section: Introductionmentioning

confidence: 99%

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UTE T2* cartilage mapping in the hip: a pilot study assessing cartilage in patients with femoroacetabular impingement

Wong,

Igbinoba,

Tokaria

et al. 2023

Acta Radiol

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Background UTE T2* cartilage mapping use in patients undergoing femoroacetabular impingement (FAI) has been lacking but may allow the detection of early cartilage damage. Purpose To assess the reproducibility of UTE T2* cartilage mapping and determine the difference in UTE T2* values between FAI and asymptomatic patients and to evaluate the correlation between UTE T2* values and patient-reported symptoms. Material and Methods Prospective evaluation of both hips (7 FAI and 7 asymptomatic patients). Bilateral hip 3-T MRI scans with UTE T2* cartilage maps were acquired. A second MRI scan was acquired 1–9 months later. Cartilage was segmented into anterosuperior, superior, and posterosuperior regions. Assessment was made of UTE T2* reproducibility (ICC). Mean UTE T2* values in patients were compared ( t-tests) and correlation was made with patient-reported outcomes (Spearman's). Results ICCs of mean UTE T2* were as follows: acetabular, 0.82 (95% CI=0.50–0.95); femoral, 0.76 (95% CI=0.35–0.92). Significant strong correlation was found between mean acetabular UTE T2* values and iHOT12 (ρ = −0.63) and moderate correlation with mHHS (ρ = −0.57). There was no difference in mean UTE T2* values between affected vs. non-affected FAI hips. FAI-affected hips had significantly higher values in acetabulum vs. asymptomatic patients (13.47 vs. 12.55 ms). There was no difference in mean femoral cartilage values between the FAI-affected hips vs. asymptomatic patients. The posterosuperior femoral region had a higher mean value in non-affected FAI hips vs. asymptomatic patients (12.60 vs. 11.53 ms). Conclusion UTE T2* cartilage mapping had excellent reproducibility. Affected FAI hips had higher mean acetabular UTE T2* values than asymptomatic patients. Severity of patient-reported symptoms correlates with UTE T2* acetabular cartilage values.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 74%

“…Automated mean UTE T2* data were generated for each ROI. This segmentation technique was previously shown to have high intra- and inter-observer reliability (12).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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UTE T2* cartilage mapping in the hip: a pilot study assessing cartilage in patients with femoroacetabular impingement

Wong,

Igbinoba,

Tokaria

et al. 2023

Acta Radiol

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“…Previous in vitro studies have confirmed that UTE-T2* mapping is a potential method for evaluating the quality of cartilage, as it is sensitive to the destruction of deep cartilage (12,38,39). Williams et al (22) claimed that UTE-T2* mapping has lower values in severely degraded cartilage compared to healthy cartilage.…”

Section: Discussionmentioning

confidence: 98%

Preliminary study on the assessment of early cartilage degeneration by quantitative ultrashort echo time magnetic resonance imaging in vivo

Su¹,

Zhang²,

Gao³

et al. 2022

Quant Imaging Med Surg

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Background: To investigate the feasibility of quantitative ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques for assessing early cartilage degeneration in vivo.Methods: A total of 46 patients with knee pain due to osteoarthritis (OA) as the main complaint were recruited into the study. We performed MRI examinations with different quantitative UTE-MRI techniques, including UTE-based magnetization transfer (MT), UTE-adiabaticT1ρ, and UTE-T2* mapping on a 3.0T clinical magnetic resonance (MR) scanner (MR750; GE Healthcare, Milwaukee, WI, USA). Three regions of interest (ROIs) were manually drawn on the medial and lateral femoral condyles and the corresponding medial and lateral tibial plateaus, respectively. A total of 561 ROIs (12 ROIs for each knee) were finally included and divided into 3 groups according to the MRI Osteoarthritis Knee Score (MOAKS): normal (MOAKS 0, n=175), mild degeneration (MOAKS 1, n=283), and moderate degeneration (MOAKS 2, n=103). One-way analysis of variance (ANOVA) and Tamhane's T2 test were used to compare the differences of quantitative UTE-biomarkers among different groups. The analysis of Spearman's correlation was used to assess the correlation between the UTE-biomarkers and MOAKS grading. The diagnostic efficacy of different quantitative UTE-MRI techniques for detecting mild cartilage degeneration was evaluated using the receiver operating characteristic (ROC) curve. Results:The UTE-MT ratio (UTE-MTR) and the UTE-adiabatic T1ρ values had a moderate correlation with the MOAKS grading (r=−0.523, P<0.001; r=0.531, P<0.001, respectively), while the UTE-T2* was weakly correlated with the MOAKS grading (r=−0.396, P<0.001). For the normal group (MOAKS 0) and the mild group (MOAKS 1), the UTE-MTR values were 21.09%±3.03% and 17.30%±3.22%, respectively. The UTE-adiabatic T1ρ values were 30.43±6.26 ms and 35.05±8.78 ms for the normal group (MOAKS 0) and the mild group (MOAKS 1), respectively. With respect to the UTE-T2* values, the normal group (MOAKS 0) values were 21.49±3.96 ms and the mild group (MOAKS 1) values were 19.86±3.08 ms. All the differences between the 2 groups of the 3 UTE-MRI values were significant. The AUCs of the UTE-MTR, UTEadiabatic T1ρ, and UTE-T2* mapping were 0.794, 0.732, and 0.651, respectively. Conclusions:The quantitative UTE-MRI techniques (UTE-MT, UTE-adiabatic T1ρ, and UTE-T2* mapping) show great promise for assessing the early degeneration of articular cartilage in vivo, and the UTE-We present the following article in accordance with the STARD reporting checklist (available at https://qims. amegroups.com/article/view/10.21037/qims-21-1181/rc). Methods ParticipantsA total of 46 OA patients, including 26 males (age range: 30 to 71 years; 48.3±11.1 years) and 20 females (age range: 37 to 72 years; 51.0±7.9 years) with complaints of knee joint discomfort and no contraindication to MRI examination were recruited within a year. Among them, 5 patients were scanned bilaterally. The exclusion criteria included previous knee surgery or traumatic knee i...

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Comparing the Effect of Mechanical Loading on Deep and Superficial Cartilage Using Quantitative UTE MRI

Wang,

Li,

et al. 2023

Magnetic Resonance Imaging

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BackgroundThe biomechanical properties of deep and superficial cartilage may be different, yet in vivo MRI validation is required.PurposeTo compare the effect of mechanical loading on deep and superficial cartilage in young healthy adults using ultrashort echo time (UTE)‐T2* mapping.Study TypeProspective, intervention.SubjectsThirty‐one healthy adults (54.8% females, median age = 23 years).Field Strength/Sequence3‐T, PD‐FS, and UTE sequences with four echo times (TEs = 0.1, 0.5, 2.8, and 4.0 msec; 0.6 mm isotropic spatial resolution) of the left knee, acquired before and after loading exercise.AssessmentQuantitative UTE‐T2* maps of the entire knee were generated using UTE images of four TEs. In deep and superficial cartilage of patella, medial and lateral femur, medial and lateral tibia cartilage (PC, MFC, LFC, MTC, and LTC), which were segmented manually, cartilage thickness and T2* values before and after loading were measured, extracted, taken averages of, and compared. Scan–rescan repeatability was evaluated. Body weight and body mass index (BMI) data were collected. Physical activity levels were evaluated using International Physical Activity Questionnaire.Statistical TestsPaired sample t‐tests, paired Wilcoxon Mann–Whitney tests, Pearson and Spearman correlation analyses, Kruskal–Wallis tests with post‐hoc Bonferroni correction. A P‐value <0.05 was considered statistically significant.ResultsThe scan–rescan repeatability was good (RMSA‐CV < 10%). After exercise, deep cartilage exhibited no significant differences in cartilage thickness (PPC = 0.576, PMTC = 0.991, PMFC = 0.899, PLTC = 0.861, PLFC = 0.290) and T2* values (PPC = 0.914, PMTC = 0.780, PMFC = 0.754, PLTC = 0.327, PLFC = 0.811), which both significantly decreased in superficial PC, MFC, LFC, and MTC. The T2* values of superficial MTC and deep MFC were moderately correlated with higher body weight (ρ = 0.431) and lower BMI (ρ = −0.499), respectively.Data ConclusionDeep and superficial cartilage may respond differently to mechanical loading as assessed by UTE‐T2*.Evidence Level2Technical EfficacyStage 3

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Feasibility of ultrashort echo time (UTE) T2* cartilage mapping in the hip: a pilot study

Cited by 6 publications

References 29 publications

UTE T2* cartilage mapping in the hip: a pilot study assessing cartilage in patients with femoroacetabular impingement

UTE T2* cartilage mapping in the hip: a pilot study assessing cartilage in patients with femoroacetabular impingement

Preliminary study on the assessment of early cartilage degeneration by quantitative ultrashort echo time magnetic resonance imaging in vivo

Comparing the Effect of Mechanical Loading on Deep and Superficial Cartilage Using Quantitative UTE MRI

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