Feasibility of tissue magnetic resonance imaging

Paelinck, Bernard P.; Roos, Albert de; Bax, Jeroen J.; Bosmans, Johan; Geest, Rob J. van der; D'hondt, D.; Parizel, Paul M.; Vrints, Christiaan J.; Lamb, Hildo J.

doi:10.1016/j.jacc.2004.12.051

Cited by 130 publications

(53 citation statements)

References 30 publications

(40 reference statements)

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“…CMR's good spatial resolution, field of view, and range of tissue contrasts allow correlation of cardiac function with morphologic and tissue characteristics. Measurements analogous to TTE measurements, such as TMF, PVF, and myocardial tissue velocities, can be performed with velocity phase-contrast CMR, which has demonstrated excellent agreement with Doppler [10,11]. Similar agreement with TTE has also been reported for CMR derived LV volume-time curves [12,13].…”

Section: Introductionmentioning

confidence: 75%

Evaluation of diastolic function by three-dimensional volume tracking of the mitral annulus with cardiovascular magnetic resonance: comparison with tissue Doppler imaging

Chyou

Chung

et al. 2014

Journal of Cardiovascular Magnetic Resonance

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BackgroundMeasurement of mitral annulus (MA) dynamics is an important component of the evaluation of left ventricular (LV) diastolic function; MA velocities are commonly measured using tissue Doppler imaging (TDI). This study aimed to examine the clinical potential of a semi-automated cardiovascular magnetic resonance (CMR) technique for quantifying global LV diastolic function, using 3D volume tracking of the MA with conventional cine-CMR images.Methods124 consecutive patients with normal ejection fraction underwent both clinically indicated transthoracic echocardiography (TTE) and CMR within 2 months. Interpolated 3D reconstruction of the MA over time was performed with semi-automated atrioventricular junction (AVJ) tracking in long-axis cine-CMR images, producing an MA sweep volume over the cardiac cycle. CMR-based diastolic function was evaluated, using the following parameters: peak volume sweep rates in early diastole (PSRE) and atrial systole (PSRA), PSRE/PSRA ratio, deceleration time of sweep volume (DTSV), and 50% diastolic sweep volume recovery time (DSVRT50); these were compared with TTE diastolic measurements.ResultsPatients with TTE-based diastolic dysfunction (n = 62) showed significantly different normalized MA sweep volume profiles compared to those with TTE-based normal diastolic function (n = 62), including a lower PSRE (5.25 ± 1.38 s−1 vs. 7.72 ± 1.7 s−1), a higher PSRA (6.56 ± 1.99 s−1 vs. 4.67 ± 1.38 s−1), a lower PSRE/PSRA ratio (0.9 ± 0.44 vs. 1.82 ± 0.69), a longer DTSV (144 ± 55 ms vs. 96 ± 37 ms), and a longer DSVRT50 (25.0 ± 11.0% vs. 15.6 ± 4.0%) (all p < 0.05). CMR diastolic parameters were independent predictors of TTE-based diastolic dysfunction after adjusting for left ventricular hypertrophy, hypertension, and coronary artery disease. Good correlations were observed between CMR PSRE/PSRA and early-to-late diastolic annular velocity ratios (e′/a′) measured by TDI (r = 0.756 to 0.828, p < 0.001).Conclusions3D MA sweep volumes generated by semi-automated AVJ tracking in routinely acquired CMR images yielded diastolic parameters that were effective in identifying patients with diastolic dysfunction when correlated with TTE-based variables.

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Section: Introductionmentioning

confidence: 75%

Evaluation of diastolic function by three-dimensional volume tracking of the mitral annulus with cardiovascular magnetic resonance: comparison with tissue Doppler imaging

Chyou

Chung

et al. 2014

Journal of Cardiovascular Magnetic Resonance

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“…Peak (E-dec peak ) and mean (E-dec mean ) deceleration gradients of the E wave were also calculated34. LV filling pressures (E/Ea) were estimated35. Diastolic function was classified according to current European Association of Echocardiography and American Society of Echocardiography guidelines21.…”

Section: Methodsmentioning

confidence: 99%

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Gonzalo-Calvo

Kenneweg

Bang

et al. 2016

Sci Rep

131

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Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy age-matched volunteers were enrolled in the study. Left ventricular (LV) parameters were measured by magnetic resonance imaging. A panel of lncRNAs was quantified in serum by RT-qPCR. No differences in expression levels of lncRNAs were observed between type 2 diabetes patients and healthy volunteers. In patients with type 2 diabetes, long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) was inversely associated with diastolic function, measured as E/A peak flow (P < 0.050 for all linear models). LIPCAR was positively associated with grade I diastolic dysfunction (P < 0.050 for all logistic models). Myocardial infarction-associated transcript (MIAT) and smooth muscle and endothelial cell-enriched migration/differentiation-associated long noncoding RNA (SENCR) were directly associated with LV mass to LV end-diastolic volume ratio, a marker of cardiac remodelling (P < 0.050 for all linear models). These findings were validated in a sample of 30 patients with well-controlled type 2 diabetes. LncRNAs are independent predictors of diastolic function and remodelling in patients with type 2 diabetes.

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“…Furthermore, using left atrial volume and phase contrast flow measurements as surrogates of left sided cardiac pressures and cardiac output pulmonary vascular resistance could be estimated showing the feasibility of MRI to estimate key pulmonary haemodyamic biomarkers [120]. Greater promise for estimating left sided heart pressure through the measurement of trans-mitral flow and myocardial tissue velocity has been shown, as performed with MRI may improve the reliability of the estimations [121]. Table 1 presents several methods of estimating pulmonary arterial pressure and pulmonary vascular resistance.…”

Section: Non-invasive Assessment Of Hemodynamics With Mrimentioning

confidence: 99%

Quantitative Magnetic Resonance Imaging of Pulmonary Hypertension

Swift

Wild

Nagle

et al. 2014

Journal of Thoracic Imaging

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Pulmonary hypertension (PH) is a condition of varied aetiology, commonly associated with a poor clinical outcome. Patients are categorised on the basis of pathophysiological, clinical, radiological and therapeutic similarities. Pulmonary arterial hypertension (PAH) is often diagnosed late in its disease course with outcome dependent on aetiology, disease severity and response to treatment. Recent advances in quantitative MR imaging allow for a better initial characterization and measurement of the morphologic and flow related changes that accompany the response of the heart-lung axis to prolonged elevation of pulmonary arterial pressure and resistance and provide a reproducible, comprehensive and non-invasive means of assessing the course of the disease and response to treatment. Typical features of pulmonary arterial hypertension (PAH) occur primarily as a result of increased pulmonary vascular resistance and resultant increased RV afterload. Several MRI derived diagnostic markers have emerged, such as ventricular mass index (VMI), interventricular septal configuration and average pulmonary artery velocity having reported diagnostic accuracy similar to Doppler echocardiography. Furthermore, prognostic markers have been identified with independent predictive value for identification of treatment failure. Such markers include: large right ventricular end-diastolic volume index (RVEDVI), low left ventricular end diastolic volume index (LVEDVI), low right ventricular ejection fraction (RVEF) and relative area change of the pulmonary trunk. MRI is ideally suited to longitudinal follow-up of patients with PAH due to its non-invasive nature, high reproducibility and has the advantage over other biomarkers in PAH due to its sensitivity to change in morphological, functional and flow related parameters. Further study the role of MR imaging as a biomarker in the clinical environment is warranted.

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Feasibility of tissue magnetic resonance imaging

Abstract: Tissue MR imaging is a feasible method to assess Ea. Combining E and Ea allowed similar estimation of filling pressure by MR and Doppler, in good agreement with invasive measurement. The potential confounding effect of valvular regurgitation needs further study.

Cited by 130 publications

References 30 publications

Evaluation of diastolic function by three-dimensional volume tracking of the mitral annulus with cardiovascular magnetic resonance: comparison with tissue Doppler imaging

Evaluation of diastolic function by three-dimensional volume tracking of the mitral annulus with cardiovascular magnetic resonance: comparison with tissue Doppler imaging

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Quantitative Magnetic Resonance Imaging of Pulmonary Hypertension

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