Feasibility of simultaneous high‐resolution anatomical and quantitative <scp>magnetic resonance</scp> imaging of sciatic nerves in patients with <scp>Charcot–Marie–Tooth</scp> type <scp>1A</scp> (<scp>CMT1A</scp>) at <scp>7T</scp>

Sveinsson, Bragi; Rowe, Olivia; Stockmann, Jason P.; Park, Daniel J; Lally, Peter J; Rosen, Matthew S.; Barry, Robert; Eichler, Florian; Rosen, Bruce R.; Sadjadi, Reza

doi:10.1002/mus.27647

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…A high-resolution ADC mapping of human sciatic nerve fascicles in patients with Charcot-Marie-Tooth type 1A was recently presented using DESS at 7-T MRI. 55 The in-plane resolution was 0.15 mm Â 0.15 mm with a slice thickness of 2 mm, significantly higher than the typical spatial resolution adopted in DW-EPI of peripheral nerves (> 1 mm for inplane, $ 3 mm for slice thickness). The diffusion sensitivity of the steady-state sequence also develops high susceptibility to motion artifacts.…”

Section: Non-diffusion-weighted Echo Planar Imaging Sequencesmentioning

confidence: 85%

Diffusion Tensor Imaging of Peripheral Nerves: Current Status and New Developments

Yoon,

Lutz

2023

Semin Musculoskelet Radiol

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Diffusion tensor imaging (DTI) is an emerging technique for peripheral nerve imaging that can provide information about the microstructural organization and connectivity of these nerves and complement the information gained from anatomical magnetic resonance imaging (MRI) sequences. With DTI it is possible to reconstruct nerve pathways and visualize the three-dimensional trajectory of nerve fibers, as in nerve tractography. More importantly, DTI allows for quantitative evaluation of peripheral nerves by the calculation of several important parameters that offer insight into the functional status of a nerve. Thus DTI has a high potential to add value to the work-up of peripheral nerve pathologies, although it is more technically demanding. Peripheral nerves pose specific challenges to DTI due to their small diameter and DTI's spatial resolution, contrast, location, and inherent field inhomogeneities when imaging certain anatomical locations. Numerous efforts are underway to resolve these technical challenges and thus enable wider acceptance of DTI in peripheral nerve MRI.

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Section: Non-diffusion-weighted Echo Planar Imaging Sequencesmentioning

confidence: 85%

Diffusion Tensor Imaging of Peripheral Nerves: Current Status and New Developments

Yoon,

Lutz

2023

Semin Musculoskelet Radiol

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“…Double echo steady-state (DESS) can provide high-resolution, T2-weighted images for morphologic nerve assessment ( 12 , 13 ). DESS can also simultaneously generate T2 maps at identical spatial resolutions ( 12 , 14 ), eliminating the need for image registration ( 10 ) and reducing the overall exam time if T2 maps are also desired.…”

Section: Introductionmentioning

confidence: 99%

“…While T2 values may be obtained using a number of different methods, including fast spin-echo (FSE)/turbo spin-echo (TSE) at multiple echo times (5) and T2-prepared TSE (8), the most commonly-used method for T2-mapping is the conventional multi-echo spin-echo (MESE) method. While T2 mapping using MESE has been readily applied in muscle (7,9), it is limited in nerve imaging because (i) as a 2D acquisition, MESE typically has poor slice-resolution (3-6 mm) and may not be readily reformatted in different planes for nerve evaluation, and (ii) MESE has poor scan efficiency, requiring multiple echoes (8)(9)(10)(11)(12)(13)(14)(15)(16)) and often long scan times (>8 min) for acquiring high in-plane resolution (0.3 mm) (10). Nevertheless, promising findings of correlation between nerve MESE T2 and electrodiagnostic results have been observed (4,11), which motivate improving the spatial resolution of T2 mapping in peripheral nerve assessment.…”

Section: Introductionmentioning

confidence: 99%

Quantitative double echo steady state T2 mapping of upper extremity peripheral nerves and muscles

Campbell,

Sneag,

Queler

et al. 2024

Front. Neurol.

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IntroductionT2 mapping can characterize peripheral neuropathy and muscle denervation due to axonal damage. Three-dimensional double echo steady-state (DESS) can simultaneously provide 3D qualitative information and T2 maps with equivalent spatial resolution. However, insufficient signal-to-noise ratio may bias DESS-T2 values. Deep learning reconstruction (DLR) techniques can reduce noise, and hence may improve quantitation of high-resolution DESS-T2. This study aims to (i) evaluate the effect of DLR methods on DESS-T2 values, and (ii) to evaluate the feasibility of using DESS-T2 maps to differentiate abnormal from normal nerves and muscles in the upper extremities, with abnormality as determined by electromyography.Methods and resultsAnalysis of images from 25 subjects found that DLR decreased DESS-T2 values in abnormal muscles (DLR = 37.71 ± 9.11 msec, standard reconstruction = 38.56 ± 9.44 msec, p = 0.005) and normal muscles (DLR: 27.18 ± 6.34 msec, standard reconstruction: 27.58 ± 6.34 msec, p < 0.001) consistent with a noise reduction bias. Mean DESS-T2, both with and without DLR, was higher in abnormal nerves (abnormal = 75.99 ± 38.21 msec, normal = 35.10 ± 9.78 msec, p < 0.001) and muscles (abnormal = 37.71 ± 9.11 msec, normal = 27.18 ± 6.34 msec, p < 0.001). A higher DESS-T2 in muscle was associated with electromyography motor unit recruitment (p < 0.001).DiscussionThese results suggest that quantitative DESS-T2 is improved by DLR and can differentiate the nerves and muscles involved in peripheral neuropathies from those uninvolved.

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Initial findings using high‐resolution magnetic resonance imaging for visualisation of the sural nerve and surrounding anatomy in healthy volunteers at 7 Tesla

McDowell,

Zambreanu,

Salhab

et al. 2024

J Peripheral Nervous Sys

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Background and AimsHistopathological diagnosis is the gold standard in many acquired inflammatory, infiltrative and amyloid based peripheral nerve diseases and a sensory nerve biopsy of sural or superficial peroneal nerve is favoured where a biopsy is deemed necessary. The ability to determine nerve pathology by high‐resolution imaging techniques resolving anatomy and imaging characteristics might improve diagnosis and obviate the need for biopsy in some. The sural nerve is anatomically variable and occasionally adjacent vessels can be sent for analysis in error. Knowing the exact position and relationships of the nerve prior to surgery could be clinically useful and thus reliably resolving nerve position has some utility.Methods7T images of eight healthy volunteers' (HV) right ankle were acquired in a pilot study using a double‐echo in steady‐state sequence for high‐resolution anatomy images. Magnetic Transfer Ratio images were acquired of the same area. Systematic scoring of the sural, tibial and deep peroneal nerve around the surgical landmark 7 cm from the lateral malleolus was performed (number of fascicles, area in voxels and mm2, diameter and location relative to nearby vessels and muscles).ResultsThe sural and tibial nerves were visualised in the high‐resolution double‐echo in steady‐state (DESS) image in all HV. The deep peroneal nerve was not always visualised at level of interest. The MTR values were tightly grouped except in the sural nerve where the nerve was not visualised in two HV. The sural nerve location was found to be variable (e.g., lateral or medial to, or crossing behind, or found positioned directly posterior to the saphenous vein).InterpretationHigh‐resolution high‐field images have excellent visualisation of the sural nerve and would give surgeons prior knowledge of the position before surgery. Basic imaging characteristics of the sural nerve can be acquired, but more detailed imaging characteristics are not easily evaluable in the very small sural and further developments and specific studies are required for any diagnostic utility at 7T.

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Feasibility of simultaneous high‐resolution anatomical and quantitative magnetic resonance imaging of sciatic nerves in patients with Charcot–Marie–Tooth type 1A (CMT1A) at 7T

Abstract: We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Cited by 6 publications

References 24 publications

Diffusion Tensor Imaging of Peripheral Nerves: Current Status and New Developments

Diffusion Tensor Imaging of Peripheral Nerves: Current Status and New Developments

Quantitative double echo steady state T2 mapping of upper extremity peripheral nerves and muscles

Initial findings using high‐resolution magnetic resonance imaging for visualisation of the sural nerve and surrounding anatomy in healthy volunteers at 7 Tesla

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