Feasibility of Sentinel Lymph Node Radiolocalization in Neck Node-Negative Oral Squamous Cell Carcinoma Patients

Kohno, Naoyuki; Ohno, Yoshihiro; Kihara, Keiichi; Kitahara, Satoshi; Tamura, Etsuyo; Tanabe, Tetsuya; Kosuda, Shigeru

doi:10.1159/000068655

Cited by 14 publications

(8 citation statements)

References 11 publications

(15 reference statements)

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“…When the sentinel lymph node biopsy is negative, lymph node dissection can be avoided, thereby also reducing the risk for postoperative complications. The principles of sentinel lymph node navigation surgery, originally used in breast cancer treatment, have been expanded to the treatment of other types of cancer, including head and neck squamous cell carcinoma …”

Section: Discussionmentioning

confidence: 99%

Diagnostic potential of 1‐step nucleic acid amplification assay in patients with head and neck squamous cell carcinoma based on CK19 expression in a primary lesion

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Diagnostic potential of 1‐step nucleic acid amplification assay in patients with head and neck squamous cell carcinoma based on CK19 expression in a primary lesion

et al. 2015

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“…Bei 2/6 Patienten zeigte sich angereichertes Radiokolloid nur in einer Region entsprechend dicht aneinander gedrängten Sentinel-Lymphknoten. Zum Unterschied von einigen Autoren [26], die als SentinelLymphknoten nur jene mit der stärksten Radiokolloidanreicherung betrachten, schlossen wir uns der Meinung anderer Autoren an [27,28], die auch die Möglichkeit mehrerer Sentinel-Lymphknoten vertreten. Gerade die dynamische Szintigraphie zeigt, dass sich der Lymphabfluss aus dem Tumorbereich gleichzeitig zu mehreren Lymphknoten verteilen kann (Abb.…”

Section: Diskussionunclassified

Sentinel-Lymphknoten bei oralen und oropharyngealen epithelialen Tumoren

Čizmarevič

Žargi²

2006

Wien Klin Wochenschr

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Carcinomatous metastases in regional lymph nodes worsen substantially the prognosis of patients with oral cavity and oropharyngeal cancer. Due to the high probability of occult metastasis (about 30%), during surgical resection of the primary tumor usually also elective dissection of lymph nodes is performed. Opinions on the extent of the elective neck dissection still differ, whereas selective dissection increasingly gains in importance. The aim of selective dissections, based on the predictability of formation of metastases, is the identification and exstirpation of the sentinel lymph node. In this prospective study the applicability of the concept of the sentinel lymph node in patients with oral cavity and oropharyngeal cancer was analysed. 12 patients with oral cavity and orophangeal cancer, staging T1-T3, all N0 (examined by palpation and sonography) were included. The localization of the sentinel(s) was determined preoperatively by radioisotope (Tc Nanocolloid). Sentinel(s) were identified first with a gamma probe (Neoprobe 2000); we then injected methylene blue into the peritumoral area for easier detection of the sentinel(s). The sentinels were removed and sent for frozen section examination. Regardless of the findings of the frozen section examination modified dissection was carried out. Later we compared frozen sections with paraffin microtome sections of sentinel(s) and of other exstirpated neck lymph nodes. We could identify the sentinel lymph node in all patients, in 6/12 patients we found several sentinels. If sentinels were not affected by tumor cells, there were no metastases in the downstream neck lymph nodes either. If in the sentinel lymph nodes no metastases can be determined, eliminating the environment alone could be sufficient. However, this assumption requires verification in a larger patient group.

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“…A movement toward investigating SN mapping among Japanese head and neck oncologists has developed in concert with worldwide trends. We and our Japanese colleagues have published articles on SN biopsy in English literature [3][4][5]. At the Aichi Cancer Center Hospital, starting in November 2000, we began a feasibility study of SN mapping and biopsy in N0 neck oral cancer patients and have concluded that the SN concept was applicable to head and neck cancer [5].…”

Section: Introductionmentioning

confidence: 99%

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Terada

Hasegawa

Yatabe

et al. 2010

Eur Arch Otorhinolaryngol

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The objective of the study was to evaluate the validity of sentinel node (SN) biopsy in early oral cancer patients focusing on the accuracy of intraoperative diagnoses of SN status, recurrences in follow-up and impact on patient survival. Previously untreated N0 oral cancer patients were candidates for the study. Using a radioisotope method, an intraoperative SN biopsy was performed. Patients with a positive frozen section of SN underwent immediate neck dissection as a single-stage procedure; they were followed in our outpatient clinic. Forty-five cT1-2N0 patients with squamous cell carcinoma were analyzed. There were seven patients with positive SN, five of whom were detected by intraoperative frozen section analysis. The sensitivity, specificity and accuracy of the intraoperative frozen section analysis of SN were 71.4, 100 and 95.6%, respectively. There were 13 recurrences in the course of all patients treated. Those with positive SN showed a tendency toward recurrence. Three patients with negative SN suffered from delayed ipsilateral neck recurrence. These were considered false negatives at a rate of 7.9%. The 5-year overall survival rate of all patients was 91.1%. SN-positive patient survival was significantly poorer than that of SN-negative patients. Positive SN had a negative impact on the survival. SN biopsy was shown to be a valuable method for determining the neck status of early oral cancer patients. The concordance rate of intraoperative multislice frozen section analysis of SN and patient neck status at the time of operation was 95.6%. SN-positive patients exhibited a tendency toward cancer recurrence. There were three cases of false negatives not conforming to the SN concept and their rate was 7.9%. Positive SN had a negative impact on patient survival.

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Feasibility of Sentinel Lymph Node Radiolocalization in Neck Node-Negative Oral Squamous Cell Carcinoma Patients

Cited by 14 publications

References 11 publications

Diagnostic potential of 1‐step nucleic acid amplification assay in patients with head and neck squamous cell carcinoma based on CK19 expression in a primary lesion

Diagnostic potential of 1‐step nucleic acid amplification assay in patients with head and neck squamous cell carcinoma based on CK19 expression in a primary lesion

Sentinel-Lymphknoten bei oralen und oropharyngealen epithelialen Tumoren

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

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