Feasibility of Retinoids for the Treatment of Emphysema Study

Roth, Michael D.; Connett, John E.; DʼArmiento, Jeanine; Foronjy, Robert; Friedman, Paul J.; Goldin, Jonathan G.; Louis, Thomas A.; Mao, Jenny T.; Muindi, Josephia R.; O’Connor, George T.; Ramsdell, Joe; Ries, Andrew L.; Scharf, Steven M.; Schluger, Neil W.; Sciurba, Frank C.; Skeans, M. A.; Walter, Robert; Wendt, Christine; Wise, Robert A.

doi:10.1378/chest.130.5.1334

Cited by 146 publications

(122 citation statements)

References 32 publications

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“…In emphysema, despite the numerous encouraging experimental data, no definitive clinical benefits of RA treatment have been observed in pilot studies [88]. The RA isoform used, dosage and drug pharmacokinetics are certainly major issues [89].…”

Section: Retinoids For the Prevention And Treatment Of Bpd And Emphysemamentioning

confidence: 99%

Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets

Bourbon

Boucherat

Boczkowski

et al. 2009

Trends in Molecular Medicine

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Section: Retinoids For the Prevention And Treatment Of Bpd And Emphysemamentioning

confidence: 99%

Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets

Bourbon

Boucherat

Boczkowski

et al. 2009

Trends in Molecular Medicine

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“…A small molecule, all-trans retinoic acid, is a media supplement often added to primary airway epithelial cell culture (92), and has shown mixed potential for reversal of COPD-induced alveolar injury in human and animal trials (93)(94)(95)(96)(97). From a tissue engineering perspective, the inclusion of such a molecule within an in vitro 3D culture system could enhance maintenance of airway cell culture (98,99).…”

Section: Signalling Factors In Airway Growth and Developmentmentioning

confidence: 99%

Respiratory Tissue Engineering: Current Status and Opportunities for the Future

O’Leary

Gilbert

O’Dea

et al. 2015

Tissue Engineering Part B: Reviews

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“…Finally, the Feasibility of Retinoids for the Treatment of Emphysema (FORTE) (ClinicalTrials.gov Identifier: NCT00000621) study pilot trial, published in 2006, found no observable clinical benefits to the administration of retinoids to patients with moderate-tosevere COPD. 38 To respond to the growing need for randomized clinical trials for COPD patients, NHLBI established the COPD Clinical Research Network (CCRN) 39 in 2003. 40 Its aim was to form a multi-center network that would perform multiple short-term clinical trials in individuals with COPD.…”

Section: Clinical Trialsmentioning

confidence: 99%

A Decade of National Heart, Lung, and Blood Institute Programs Supporting COPD Research and Education

et al. 2014

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The past decade of research in chronic obstructive pulmonary disease (COPD) has seen a new age of understanding both pathogenic mechanisms and clinical manifestations of the disease. The National Heart, Lung, and Blood Institute (NHLBI) has helped guide this progress with a series of initiatives to stimulate COPD research in various ways. These initiatives were designed to promote a precision medicine approach to treating COPD, one that takes advantage of targeting particular molecular pathways and the individual pathobiologies of the diversity of COPD patients. This review describes the strategic objectives of these initiatives, as well as some of their observed and anticipated outcomes. In addition, we address parallel steps NHLBI has taken to promote COPD awareness among the public. As we look toward the immediate future of COPD research and education, we see a time of great progress in terms of understanding and treatment. Furthermore, while this remains a debilitating and disturbingly prevalent disease, as NHLBI looks even farther ahead, we envision emerging efforts toward COPD prevention.

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Feasibility of Retinoids for the Treatment of Emphysema Study

Cited by 146 publications

References 32 publications

Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets

Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets

Respiratory Tissue Engineering: Current Status and Opportunities for the Future

A Decade of National Heart, Lung, and Blood Institute Programs Supporting COPD Research and Education

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