Feasibility of reducing the maximum shelf life of red blood cells stored in additive solution: a dynamic simulation study involving a large regional blood system

Grasas, Alex; Pereira, Arturo; Bosch, Mark; Ortiz, Pilar; Puig, Lluís

doi:10.1111/vox.12224

Cited by 14 publications

(6 citation statements)

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“…With a 35‐day shelf‐life, their ODR was only 1.3%–1.4% and a shortage rate of 0.05%, relying on the strategies to limit the length of inventory held at the blood supplier headquarters to 8–10 days. This approach could not be adopted at our HAs because the median age of blood received from the blood supplier was higher at 11 days [22].…”

Section: Discussionmentioning

confidence: 99%

The estimated negative impacts on the red blood cell inventory of reducing shelf‐life at two large health authorities in British Columbia, Canada, using a discrete‐event simulation model

et al. 2023

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Background and Objectives Reducing the maximum red blood cell (RBC) shelf‐life is under consideration due to potential negative effects of older blood. An assessment of the impacts of this change on blood supply chain management is evaluated. Materials and Methods We performed a simulation study using data from 2017 to 2018 to estimate the outdate rate (ODR), STAT order and non‐group‐specific RBC transfusion at two Canadian health authorities (HAs). Results Shortening shelf‐life from 42 to 35 and 28 days led to the following: ODRs (in percentage) in both HAs increased from 0.52% (95% confidence interval [CI] 0.50–0.54) to 1.32% (95% CI 1.26–1.38) and 5.47% (95% CI 5.34–5.60), respectively (p < 0.05). The estimated yearly median of outdated RBCs increased from 220 (interquartile range [IQR] 199–242) to 549 (IQR 530–576) and 2422 (IQR 2308–2470), respectively (p < 0.05). The median number of outdated redistributed units increased from 152 (IQR 136–168) to 356 (IQR 331–369) and 1644 (IQR 1591–1741), respectively (p < 0.05). The majority of outdated RBC units were from redistributed units rather than units ordered from the blood supplier. The estimated weekly mean STAT orders increased from 11.4 (95% CI 11.2–11.5) to 14.1 (95% CI 13.1–14.3) and 20.9 (95% CI 20.6–21.1), respectively (p < 0.001). The non‐group‐specific RBC transfusion rate increased from 4.7% (95% CI 4.6–4.8) to 8.1% (95% CI 7.9–8.3) and 15.6% (95% CI 15.3–16.4), respectively (p < 0.001). Changes in ordering schedules, decreased inventory levels and fresher blood received simulated minimally mitigated these impacts. Conclusion Decreasing RBC shelf‐life negatively impacted RBC inventory management, including increasing RBC outdating and STAT orders, which supply modifications minimally mitigate.

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Section: Discussionmentioning

confidence: 99%

The estimated negative impacts on the red blood cell inventory of reducing shelf‐life at two large health authorities in British Columbia, Canada, using a discrete‐event simulation model

et al. 2023

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“…Demand forecasting is another popular perspective for the inventory stage [112,[118][119][120][121]. Finally, a recently popular research area is determining the effects of changing the shelf life of blood products [37,71,122,123].…”

Section: Inventorymentioning

confidence: 99%

A Systematic Literature Review of the Blood Supply Chain through Bibliometric Analysis and Taxonomy

Imamoglu

Topçu

Aydın

2023

Systems

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The blood supply chain is an inseparable part of health systems. The importance of blood and the difficulties of managing the blood supply chain have led to numerous publications on this topic over the last two decades. This study seeks to reveal the state of the art of the blood supply chain and provide research gaps and future research directions. For this purpose, a mixed review methodology is conducted that includes bibliometric analysis, network analysis, and a six-dimension taxonomy. Bibliometric analysis identifies the most contributing journals, authors, and countries as well as provides popular keywords, while network analysis reveals interactions between these components. Taxonomy clarifies decision models and research gaps with a deeper examination. The electronic database Web of Science is examined to uncover relevant articles. In total, 265 articles are analyzed in detail. The findings reveal that the blood supply chain gathers more interest from researchers, and despite the continuing dominance of the inventory stage, there is an upward trend in the literature for the research of the blood supply chain as a whole. Optimization techniques come forward in the blood supply chain topic as solution methodology. In accordance with the results of bibliometric analysis, network analysis, and taxonomy, six prospective directions for future research are emphasized.

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“…Such an approach might consider limiting the storage duration to 28-35 days rather than 42 days. Simulation models from Héma-Québec (Blake et al, 2012) and the Catalan Blood Agency (Grasas et al, 2014) found that shelf life could be reduced to 28 days without excessive outdating or risk of blood shortages, even during periods where collection is suspended for up to 5 days. Blood storage policies need not be rigid; in times of severe shortages, one might consider extending allowable shelf life.…”

Section: Dear Sirmentioning

confidence: 99%

Clinical trials and the age of blood: ABLE but still wanting

Chin‐Yee

Pereira

2015

Transfusion Medicine

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Feasibility of reducing the maximum shelf life of red blood cells stored in additive solution: a dynamic simulation study involving a large regional blood system

Abstract: Reductions of MSL to 28-35 days seem feasible and riskless and do not require major changes in the inventory management policies. Consequently, and giving preponderance to the precautionary principle, the Catalan Blood Agency has decided to reduce the MSL of RBCs from 42 to 35 days.

Cited by 14 publications

References 14 publications

The estimated negative impacts on the red blood cell inventory of reducing shelf‐life at two large health authorities in British Columbia, Canada, using a discrete‐event simulation model

The estimated negative impacts on the red blood cell inventory of reducing shelf‐life at two large health authorities in British Columbia, Canada, using a discrete‐event simulation model

A Systematic Literature Review of the Blood Supply Chain through Bibliometric Analysis and Taxonomy

Clinical trials and the age of blood: ABLE but still wanting

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