Feasibility of Raman spectroscopic identification of gall bladder cancer using extracellular vesicles extracted from bile

Abstract

Extracellular vesicles (EVs), heterogeneous membrane-based vesicles with bilayer cell membrane structures, could be versatile biomarkers for identification of diverse diseases including cancers. With this potential, this study has attempted the...

Toward the nanoscale chemical and physical probing of milk-derived extracellular vesicles using Raman and tip-enhanced Raman spectroscopy

“…, to assess their purity or for diagnostic purposes. 10,35–43 While confocal Raman spectroscopy involves the global analysis of the mean properties of a large number of vesicles, TERS may enable the investigation of single EVs with high spatial resolution, e.g. , to identify domains and specific fingerprint areas to be used as biomarkers.…”