Feasibility of Radical Transurethral Resection as Monotherapy for Selected Patients With Muscle Invasive Bladder Cancer

Solsona, E.; Iborra, I.; Collado, A.; Rubio‐Briones, J.; Casanova, J.; Calatrava, Ana

doi:10.1016/j.juro.2010.04.008

Cited by 84 publications

(49 citation statements)

References 17 publications

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“…The 10-year cancer-specific survival was similar in these two groups and, furthermore, 57% of those managed with TUR alone survived with their bladders intact [Herr, 2001]. A prospective phase II study of 133 patients with muscleinvasive bladder cancer managed with radical TUR alone demonstrated a 79.5% overall survival and 64.9% bladder-intact survival at 10 years [Solsona et al 2010]. The key inclusion criteria for this trial were no residual tumor (pT0) upon repeat biopsy of the tumor bed and absence of hydronephrosis.…”

Section: Radical Transurethral Resection Alonementioning

confidence: 86%

Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy

Balar

Bajorin

Milowsky

2011

Therapeutic Advances in Urology

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Bladder cancer is a common malignancy seen in older adults with coexisting medical illnesses. The management of patients with muscle invasive disease includes perioperative chemotherapy and radical cystectomy; however, patients may decline surgery and older patients with comorbid conditions may not be candidates for surgery and thus alternative treatment strategies are needed. Trimodality bladder preservation protocols for muscle invasive bladder cancer have generally included only those patients who are candidates for a salvage cystectomy. In this review, we discuss the current status of bladder preservation treatment options for patients with muscle-invasive disease who are not candidates for cystectomy or who decline surgery and highlight the need for clinical trials investigating novel treatment approaches in this older patient population.

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Section: Radical Transurethral Resection Alonementioning

confidence: 86%

Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy

Balar

Bajorin

Milowsky

2011

Therapeutic Advances in Urology

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“…Em estadios II a IV (M0) pode-se considerar quimioterapia neoadjuvante com esquemas a base de Cisplatina, seguido por cistectomia radical e linfadenectomia estendida. Se for identificada doença com invasão da camada muscular profunda é indicado quimioterapia adjuvante por 4 ciclos após cistectomia radical, podendo ser substituída por radioterapia ou máxima ressecção transuretral e quimioterapia paliativa nos pacientes não candidatos à cirurgia (SOLSONA, et al, 2010).…”

Section: Discussionunclassified

Relato De Caso: Resposta Completa Com Quimioterapia De Segunda Linha Em Câncer De Bexiga Estadio Iv

Freitas¹,

Gonçalves

2018

Acta Biomed.Bras.

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RESUMOO câncer de bexiga é a neoplasia mais comum do sistema urinário, sendo raro ocorrer casos de resposta completa a quimioterapia em tumores avançados, quando não realizado cirurgia com intuito curativo. Objetivo: relatar o caso de um paciente que apresentou resposta completa da neoplasia vesical em estadio IV após quimioterapia de 2ª linha.Palavras chave: Sistema urinário; Câncer de bexiga; Quimioterapia. ABSTRACTBladder cancer is the most common neoplasm of the urinary system, and cases of complete response to chemotherapy in advanced tumors are rare, when surgery for curative purposes is not performed. Objective: To report the case of a patient who presented complete response of stage IV bladder neoplasia after 2 nd line chemotherapy.

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“…Although these treatment options have fewer complications than a RC initially, the complications increase over time. Even in highly selected patient groups, both MIBC recurrence and tumor progression occur in 30% of patients with MIBC treated with TURBT alone [26] . BCG instillation therapy has a lower response in elderly patients and a higher rate of complications, such as bladder pain, voiding symptoms and fever [27,28] .…”

Section: Discussionmentioning

confidence: 99%

How Octogenarians with Bladder Cancer Are Treated in a Maximum-Care Hospital: The Real-Life Experience

Sikic

Wach²,

Täubert³

et al. 2016

Urol Int

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Introduction: With increasing life expectancy, curative treatment of octogenarians with urothelial carcinoma of the bladder (UCB) becomes more important. Materials and Methods: The treatment modalities of 276 octogenarians with UCB who were treated at the University Hospital of Erlangen between 1982 and 2011 were assessed retrospectively. Results: One hundred forty-six patients had non-muscle invasive bladder cancer (NMIBC) while 71 had muscle invasive bladder cancer (MIBC). No data was available for 59 patients. Eighty-five (58.2%) of the 146 patients with NMIBC received transurethral resection of the bladder tumor (TURBT) only, another 38 patients (26%) underwent additional intravesical therapy; and 8.9% were treated with radiochemotherapy (RCT), 4.1% with radiotherapy (RT), 1.4% with systemic chemotherapy and 1.4% with radical cystectomy (RC). Of the 71 patients suffering from MIBC, 39 (54.9%) received TURBT alone. A potentially curative therapy was performed on 31 of the 71 patients with MIBC (43.7%). Of these, 16 patients (51.6%) received RCT, 9 patients (29.0%) RT and 6 patients (19.4%) RC. In Kaplan-Meier analysis, patients with MIBC had better median overall survival with curative treatment compared to TURBT alone (28 vs. 9 months; p < 0.001, log-rank test). Conclusions: By offering a wide range of treatment options, over 43% of octogenarians with MIBC received a curative therapy at a maximum care hospital.

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Feasibility of Radical Transurethral Resection as Monotherapy for Selected Patients With Muscle Invasive Bladder Cancer

Abstract: Radical transurethral bladder tumor resection is a reliable therapeutic approach for patients with muscle invasive bladder cancer after complete tumor resection and with negative biopsies of the tumor bed. These results are consistent in all age ranges.

Cited by 84 publications

References 17 publications

Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy

Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy

Relato De Caso: Resposta Completa Com Quimioterapia De Segunda Linha Em Câncer De Bexiga Estadio Iv

How Octogenarians with Bladder Cancer Are Treated in a Maximum-Care Hospital: The Real-Life Experience

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