Feasibility of radiation dose reduction using AIDR-3D in dynamic pulmonary CT perfusion

Mirsadraee, Saeed; Weir, Nicholas W.; Connolly, Susan; Murchison, John T; Reid, John H.; Hirani, Nikhil; Connell, Martin; Beek, Edwin Jr van

doi:10.1016/j.crad.2015.04.004

Cited by 13 publications

(4 citation statements)

References 21 publications

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“…The swine also had a small effective diameter (23 cm) as compared to the average 34 cm effective diameter of patients with CAD [ 38 ], i.e., the performance of the technique may degrade in larger patients due to increased photon starvation and attenuation bias [ 39 ]. However, exposure control methods can maintain a fixed measurement noise for larger effective diameters, although effective dose increases proportionally, as previously approximated with water phantoms [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Combining perfusion and angiography with a low-dose cardiac CT technique: a preliminary investigation in a swine model

Hubbard

Malkasian

Zhao

et al. 2021

Int J Cardiovasc Imaging

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Morphological and physiological assessment of coronary artery disease (CAD) is necessary for proper stratification of CAD risk. The objective was to evaluate a low-dose cardiac CT technique that combines morphological and physiological assessment of CAD. The low-dose technique was evaluated in twelve swine, where three of the twelve had coronary balloon stenosis. The technique consisted of rest perfusion measurement combined with angiography followed by stress perfusion measurement, where the ratio of stress to rest was used to derive coronary flow reserve (CFR). The technique only required two volume scans for perfusion measurement in mL/min/g; hence, four volume scans were acquired in total; two for rest with angiography and two for stress. All rest, stress, and CFR measurements were compared to a previously validated reference technique that employed 20 consecutive volume scans for rest perfusion measurement combined with angiography, and stress perfusion measurement, respectively. The 32 cm diameter volumetric CT dose index ($${\text{CTDI}}_{\text{vol}}^{32}$$ CTDI vol 32 ) and size-specific dose estimate (SSDE) of the low-dose technique were also recorded. All low-dose perfusion measurements (PLOW) in mL/min/g were related to reference perfusion measurements (PREF) through regression by PLOW = 1.04 PREF − 0.08 (r = 0.94, RMSE = 0.32 mL/min/g). The $${\text{CTDI}}_{\text{vol}}^{32}$$ CTDI vol 32 and SSDE of the low-dose cardiac CT technique were 8.05 mGy and 12.80 mGy respectively, corresponding to an estimated effective dose and size-specific effective dose of 1.8 and 2.87 mSv, respectively. Combined morphological and physiological assessment of coronary artery disease is feasible using a low-dose cardiac CT technique.

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Section: Discussionmentioning

confidence: 99%

Combining perfusion and angiography with a low-dose cardiac CT technique: a preliminary investigation in a swine model

Hubbard

Malkasian

Zhao

et al. 2021

Int J Cardiovasc Imaging

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“…As a result, the artifacts caused by previous helical motions were reduced. However, FBP has relatively high requirements for the raw data; in particular, it is vulnerable to the quantities of photons needed for projection imaging, of which SD, SNR and CNR are more vulnerable; therefore, it is possible that the image quality cannot meet the diagnostic demand ( 16 , 17 ). Reconstruction with AIDR-3D is less affected by image noises; after several iterative procedures and constant optimization of noises, the SNR and CNR could be increased, so as to meet the diagnostic demands by guaranteeing the image quality ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Application value of iterative reconstruction with CTA to intractable headache patients

Zhang

et al. 2018

Exp Ther Med

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Application value of iterative reconstruction with computed tomographic angiography (CTA) in the patients with intractable headache was investigated. One hundred and eighty patients with headache, who were admitted and treated in Cangzhou Central Hospital, were selected to undergo CTA scan. The patients were divided into group A, B and C according to different scanning conditions and data reconstruction techniques. In group A, the scanning parameters were 120 kV and 300 mA, and filtered back projection (FBP) algorithm was used for data reconstruction. In group B, the scan parameters were 100 kV and automatic milliamperes. Further, adaptive iterative dose reduction via three-dimensional processing (AIDR-3D) was used for data reconstruction. In group C, the scan parameters were 80 kV with automatic milliamperes, and AIDR-3D technique was utilized for data reconstruction. The CT value, noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), subjective assessment score of image quality and radiation dose of the three groups of images were compared. There were significant differences in CT values, standard deviation (SD) values, SNRs and CNRs of different vessel segments and muscles among the three groups (P<0.05). The image assessment scores at the levels of the atlas and C7 vertebra as well as those of the brain parenchyma in the three groups had notable differences (P<0.05). However, they showed no differences at the level of the C4 vertebra (P>0.05). Further, significant differences were observed in volume computed tomography dose index (CTDIvol), dose-length product (DLP) and effective dose (ED) (P<0.05). In conclusion, for patients with intractable headache, the image quality of the CTA scan using AIDR-3D reconstruction method showed better results over FBP reconstruction method. Further, best results were observed when the scan parameters were 100 kV, automatic milliamperes and the data reconstruction was performed by AIDR-3D.

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“…Such a relation is problematic at very low tube currents, as photon starvation leads to attenuation bias, which leads to perfusion measurement inaccuracy. 34 Fortunately, work by Mirsadraee et al 34 suggests that a tube current as low as 50 mA may be used over a large range of effective diameters with minimal attenuation bias, although measurement noise increases for larger effective diameters. That being said, adequate noise reduction may still be achieved using model-based iterative reconstruction algorithms such as FIRST.…”

Section: Limitationsmentioning

confidence: 99%

“…Therefore, considerable effort was made to tightly control ventilation, anesthesia, IV fluid administration, and hemodynamics between acquisitions. As an alternative solution, artificial noise could have been added to the raw data projections of the reference standard retrospective acquisitions to simulate reduced tube current acquisitions, 34 but raw data projection access was not possible in this study. Of additional note, the swine had high heart rates-a common impediment to accurate dynamic CT perfusion measurement.…”

Section: Limitationsmentioning

confidence: 99%

Low-Radiation-Dose Stress Myocardial Perfusion Measurement Using First-Pass Analysis Dynamic Computed Tomography

et al. 2019

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Objectives: The aim of this study was to assess the feasibility of a prospective first-pass analysis (FPA) dynamic computed tomography (CT) perfusion technique for accurate low-radiation-dose global stress perfusion measurement. Materials and Methods: The prospective FPA technique was evaluated in 10 swine (42 ± 12 kg) by direct comparison to a previously validated retrospective FPA technique. Of the 10 swine, 3 had intermediate stenoses with fractional flow reserve severities of 0.70 to 0.90. In each swine, contrast and saline were injected peripherally followed by dynamic volume scanning with a 320-slice CT scanner. Specifically, for the reference standard retrospective FPA technique, volume scans were acquired continuously at 100 kVp and 200 mA over 15 to 20 seconds, followed by systematic selection of only 2 volume scans for global perfusion measurement. For the prospective FPA technique, only 2 volume scans were acquired at 100 kVp and 50 mA for global perfusion measurement. All prospective global stress perfusion measurements were then compared with the corresponding reference standard retrospective global stress perfusion measurements through regression analysis. The CTDI 32 vol and size-specific dose estimate of the prospective FPA technique were also determined. Results: All prospective global stress perfusion measurements (P PRO ) at 50 mA were in good agreement with the reference standard retrospective global stress perfusion measurements (P REF ) at 200 mA (P PRO = 1.07 P REF −0.09, r = 0.94; root-mean-square error = 0.30 mL/min per gram). The CTDI 32 vol and size-specific dose estimate of the prospective FPA technique were 2.3 and 3.7 mGy, respectively. Conclusions: Accurate low-radiation-dose global stress perfusion measurement is feasible using a prospective FPA dynamic CT perfusion technique.

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Feasibility of radiation dose reduction using AIDR-3D in dynamic pulmonary CT perfusion

Cited by 13 publications

References 21 publications

Combining perfusion and angiography with a low-dose cardiac CT technique: a preliminary investigation in a swine model

Combining perfusion and angiography with a low-dose cardiac CT technique: a preliminary investigation in a swine model

Application value of iterative reconstruction with CTA to intractable headache patients

Low-Radiation-Dose Stress Myocardial Perfusion Measurement Using First-Pass Analysis Dynamic Computed Tomography

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