Feasibility of RACT for 3D dose measurement and range verification in a water phantom

Alsanea, Fahed; Moskvin, V.; Stantz, Keith M.

doi:10.1118/1.4906241

Cited by 27 publications

(28 citation statements)

References 50 publications

(63 reference statements)

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“…Studies by Jones et al and Alsanea et al indicate that Bragg peak localization with about 1-mm precision may be possible. 12,13 These studies also showed that the use of multiple ultrasound detectors may reconstruct a tomographic image of the proton dose distribution.…”

Section: Introductionmentioning

confidence: 95%

Theoretical detection threshold of the proton‐acoustic range verification technique

et al. 2015

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The proton-acoustic process was simulated using a realistic model and the minimal detection limit was established for proton-acoustic range validation. These limits correspond to a best case scenario with a single large detector with no losses and detector thermal noise as the sensitivity limiting factor. Our study indicated practical proton-acoustic range verification may be feasible with approximately 5 × 10(6) protons/pulse and beam current.

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Section: Introductionmentioning

confidence: 95%

Theoretical detection threshold of the proton‐acoustic range verification technique

et al. 2015

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“…Hayakawa et al detected acoustic pulse signals in animal tissues and humans, demonstrating the feasibility of determining dose distribution in proton therapy . A 3D dosimetric scanner based on ionizing radiation‐induced acoustic computed tomography (RACT) was theoretically designed to verify dose distribution and proton range in a water phantom . A clinical ultrasound array was deployed to localize the proton Bragg peak from reconstructed thermoacoustic images in water and gelatin phantoms, which provided perfectly co‐registered overlay of the Bragg peak onto a standard ultrasound image acquired by the same ultrasound array, and overcame the presence of acoustic heterogeneity and speed of sound errors …”

Section: Introductionmentioning

confidence: 99%

Simulation studies of time reversal‐based protoacoustic reconstruction for range and dose verification in proton therapy

Yu¹,

Li²,

Zhang³

et al. 2019

Medical Physics

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Purpose In vivo range verification in proton therapy is a critical step to help minimize range and dose uncertainty. We propose to employ a time reversal (TR)‐based approach using proton‐induced acoustics (protoacoustics) to reconstruct pressure/dose distribution in heterogeneous tissues. Methods The dose distribution of mono‐energetic proton pencil beam in a CT‐based patient phantom was calculated by Monte Carlo simulation. K‐wave toolbox was used to investigate protoacoustic pressurization, propagation and reconstruction in 2D. To address the tissue heterogeneity effect, a number of physical parameters, including mass density (ρ), speed of sound (c), volumetric thermal expansion coefficient (αV), isobaric specific heat capacity (Cp) and attenuation power law prefactor (α0), were empirically converted from CT number. The performance was evaluated using two figures of merit: mean square error (MSE) of pressure profiles and Bragg peak localization error (ΔBP). The impact of six parameters of the TR inversion was examined, including number of sensors, sampling duration, sampling timestep, spill time, noise level and number of iterations. Results The quantitative accuracy of TR reconstruction and its dependency on the selected parameters is presented. Under optimum conditions, the positioning accuracy of the Bragg peak can be controlled below 1 mm. For instance, MSE is 0.0123 and ΔBP is 0.59 mm under the following conditions (32 sensors, sampling duration: 600 µs, sampling timestep: 40 ns, spill time: 1 µs, no noise). Conclusions The feasibility of TR‐based protoacoustic reconstruction in 2D for proton range verification was first demonstrated. The approach is not only applicable to pencil beam, but also has potential to be extended to passive scattering systems.

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“…Alsanea et al proposed radiation-induced acoustic computed tomography (RACT) in which the proton-induced acoustic signal measured by an array of transducers is used to reconstruct the 3D dose distribution through a filtered backprojection algorithm. 31,58 The reconstruction accuracy of clinical pencil beam dose depositions was investigated as a function of noise level and number of projection angles. For low noise levels (approximately equal to the maximum signal pressure amplitude), RACT showed sub-millimeter proton range verification and <2% dosimetric Bragg peak accuracy.…”

Section: B Recent Workmentioning

confidence: 99%

Ionizing radiation‐induced acoustics for radiotherapy and diagnostic radiology applications

et al. 2018

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Acoustic waves are induced via the thermoacoustic effect in objects exposed to a pulsed beam of ionizing radiation. This phenomenon has interesting potential applications in both radiotherapy dosimetry and treatment guidance as well as low-dose radiological imaging. After initial work in the field in the 1980s and early 1990s, little research was done until 2013 when interest was rejuvenated, spurred on by technological advances in ultrasound transducers and the increasing complexity of radiotherapy delivery systems. Since then, many studies have been conducted and published applying ionizing radiation-induced acoustic principles into three primary research areas: Linear accelerator photon beam dosimetry, proton therapy range verification, and radiological imaging. This review article introduces the theoretical background behind ionizing radiation-induced acoustic waves, summarizes recent advances in the field, and provides an outlook on how the detection of ionizing radiationinduced acoustic waves can be used for relative and in vivo dosimetry in photon therapy, localization of the Bragg peak in proton therapy, and as a low-dose medical imaging modality. Future prospects and challenges for the clinical implementation of these techniques are discussed.

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Feasibility of RACT for 3D dose measurement and range verification in a water phantom

Cited by 27 publications

References 50 publications

Theoretical detection threshold of the proton‐acoustic range verification technique

Theoretical detection threshold of the proton‐acoustic range verification technique

Simulation studies of time reversal‐based protoacoustic reconstruction for range and dose verification in proton therapy

Ionizing radiation‐induced acoustics for radiotherapy and diagnostic radiology applications

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