Feasibility of quantitative regional ventilation and perfusion mapping with phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients

Voskrebenzev, Andreas; Gutberlet, Marcel; Klimeš, Filip; Kaireit, Till F.; Schönfeld, Christian; Rotärmel, Alexander; Wacker, Frank; Vogel‐Claussen, Jens

doi:10.1002/mrm.26893

Cited by 148 publications

(193 citation statements)

References 25 publications

(34 reference statements)

Supporting

Mentioning

188

Contrasting

Unclassified

Order By: Relevance

“…Preprocessed datasets were analyzed for each slice separately (3 coronal slices, each with 180 timepoints) according to the PREFUL approach as follows: The respiratory phase (expiration or inspiration) of each image was estimated from the averaged signal of the rectangular lung/diaphragm ROI (previously described in the preprocessing section). Using the slope of this signal (1 st derivative), all images were sorted according to a cosine model function to reconstruct a full respiratory cycle. Fractional ventilation time series (FV t ) covering the whole breathing cycle for each voxel inside the lung were then calculated according to Zapke et al without the noise term …”

Section: Methodsmentioning

confidence: 99%

“…FD‐MRI places much lower demands on available hardware in comparison to the previously mentioned techniques, making it a clinically applicable option alongside PFT. Recent advances in postprocessing (particularly motion correction) and in analyzing FD‐MRI datasets have improved image quality and made it possible to quantify regional lung ventilation …”

mentioning

confidence: 99%

“…Quantitative parameters, which measure regional breathing dynamics derived from flow‐volume assessment during the whole breathing cycle may be more sensitive for subtle regional lung function changes. Therefore, in the present work we reconstructed the whole breathing cycle and implemented phase‐resolved functional lung MRI (PREFUL‐MRI) to generate regional flow‐volume loops for a cohort of LTx patients with different CLAD stages . The hypothesis of the present study was that PREFUL‐MRI‐derived parameters of regional flow‐volume dynamics are, contrary to FV, sensitive enough to detect early‐stage CLAD.…”

mentioning

confidence: 99%

See 2 more Smart Citations

MRI‐derived regional flow‐volume loop parameters detect early‐stage chronic lung allograft dysfunction

Alsady

Voskrebenzev

Greer

et al. 2019

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Background Chronic lung allograft dysfunction (CLAD) is a major cause for the low long‐term survival rates after lung transplantation (LTx). Early detection of CLAD may enable providing medical treatment before a nonreversible graft dysfunction has occurred. MRI is advantageous to pulmonary function testing (PFT) in the ability to assess regional function changes, and thus have the potential in detecting very early stages of CLAD before changes in global forced expiratory volume during the first second (FEV1%) occur. Purpose To examine whether early stages of CLAD (diagnosed based on PFT values) could also be detected using MRI‐derived parameters of regional flow‐volume dynamics. Study Type Retrospective. Population 62 lung transplantation recipients were included in the study, 29 of which had been diagnosed with CLAD at various stages. Field Strength/Sequence MRI datasets were acquired with a 1.5T Siemens scanner using a spoiled gradient echo sequence. Assessment MRI datasets were retrospectively preprocessed and analyzed by a blinded radiologist according to the phase resolved functional lung MRI (PREFUL‐MRI) approach, resulting in fractional ventilation (FV) maps and regional flow‐volume loops (rFVL). FV‐ and rFVL‐based parameters of regional lung ventilation were estimated. Statistical Tests Differences between groups were compared by Mann–Whitney U‐test with a Bonferroni correction for multiple comparisons (n = 2). Results rFVL‐CC‐based parameters discriminated significantly between the presence or absence of CLAD (P < 0.003). Data Conclusion Using the contrast media‐free PREFUL‐MRI technique, parameters of ventilation dynamics and its regional heterogeneity were shown to be sensitive for the detection of early CLAD stages. Level of Evidence: 3 Technical Efficacy Stage 3 J. Magn. Reson. Imaging 2019;50:1873–1882.

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

MRI‐derived regional flow‐volume loop parameters detect early‐stage chronic lung allograft dysfunction

Alsady

Voskrebenzev

Greer

et al. 2019

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similar to PREFUL and SENCEFUL, the proposed NUFD method generates functional maps where all of the signal contribution collected during the measurement can be used. Because the same amount of signal is used for the evaluation, one would expect similar SNR increases with the NUFD approach as with the 2 other methods compared to FD.…”

Section: Discussionmentioning

confidence: 99%

“…However, inevitable random variations of respiratory or cardiac frequencies during free‐breathing pulmonary measurements can be reason for artificial signal loss when using the established FD MRI approach. Related methods that have been proposed to overcome this problem require complex multiple‐step post‐processing including peak finding, exact phase estimation and data resorting of k‐space or image‐space data to use all of the measured signal variations as well as recalibrate the signal contribution to a single frequency.…”

Section: Introductionmentioning

confidence: 99%

Nonuniform Fourier‐decomposition MRI for ventilation‐ and perfusion‐weighted imaging of the lung

Bondesson

Schneider

Gaaß

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose To improve the robustness of pulmonary ventilation‐ and perfusion‐weighted imaging with Fourier decomposition (FD) MRI in the presence of respiratory and cardiac frequency variations by replacing the standard fast Fourier transform with the more general nonuniform Fourier transform. Theory and Methods Dynamic coronal single‐slice MRI of the thorax was performed in 11 patients and 5 healthy volunteers on a 1.5T whole‐body scanner using a 2D ultra‐fast balanced steady‐state free‐precession sequence with temporal resolutions of 4‐9 images/s. For the proposed nonuniform Fourier‐decomposition (NUFD) approach, the original signal with variable physiological frequencies that was acquired with constant sampling rate was retrospectively transformed into a signal with (ventilation or perfusion) frequency‐adapted sampling rate. For that purpose, frequency tracking was performed with the synchro‐squeezed wavelet transform. Ventilation‐ and perfusion‐weighted NUFD amplitude and signal delay maps were generated and quantitatively compared with regularly sampled FD maps based on their signal‐to‐noise ratio (SNR). Results Volunteers and patients showed statistically significant increases of SNR in frequency‐adapted NUFD results compared to regularly sampled FD results. For ventilation data, the mean SNR increased by 43.4%±25.3% and 24.4%±31.9% in volunteers and patients, respectively; for perfusion data, SNR increased by 93.0%±36.1% and 75.6%±62.8%. Two patients showed perfusion signal in pulmonary areas with NUFD that could not be imaged with FD. Conclusion This study demonstrates that using nonuniform Fourier transform in combination with frequency tracking can significantly increase SNR and reduce frequency overlaps by collecting the signal intensity onto single frequency bins.

show abstract

Comparison of quantitative regional perfusion‐weighted phase resolved functional lung (PREFUL) MRI with dynamic gadolinium‐enhanced regional pulmonary perfusion MRI in COPD patients

Kaireit

Voskrebenzev

Gutberlet

et al. 2018

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Background: Perfusion-weighted noncontrast-enhanced proton lung MRI during free breathing is maturing as a novel technique for assessment of regional lung perfusion, but has not yet been validated in chronic obstructive pulmonary disease (COPD) patients. Purpose: To compare pulmonary parenchymal perfusion assessed by noncontrast-enhanced perfusion-weighted phaseresolved functional lung (PREFUL)-MRI with lung perfusion determined with dynamic gadolinium-enhanced (DCE)-MRI and with lung function test parameters. Study Type: Prospective. Population: A single-center subset of the COPD cohort "COPD and SYstemic consequenzes-COmorbidities NETwork" (COSYCONET). Forty-seven patients with COPD (median age 66 [57-70] years) were studied. Field Strength/Sequence: For PREFUL-MRI a spoiled gradient echo sequence and for DCE-MRI, a 3D time-resolved spoiled gradient echo sequence was used at 1.5T. Assessment: PREFUL-MRI coronal slices were acquired in free breathing. DCE-MRI was performed in breath-hold with administration of 0.025 mmol/kg bodyweight of gadobutrol i.v. at a rate of 4 ml/s and pulmonary blood flow (PBF) maps were calculated. Slices of PREFUL and DCE-MRI were matched by their ventrodorsal position and corresponding slices were coregistered for evaluation. Perfusion defect percentages (QDP) were calculated for both methods. Statistical Tests: The obtained parameters were correlated using Spearman's correlation coefficient (r) and Bland-Altman plot analysis. Results: PREFUL-QDP showed an absolute and spatial agreement with PBF-QDP on a global (39.3 (31.8-45.5)% vs. 44.7 (35.4-50.0)% with a spatial overlap of 62.2 (57.2-67.2)%)) as well as on a lobar level and correlated with lung function test parameters (PREFUL-QDP vs. FEV 1 , r = -0.75, P < 0.0001). There was a systematic overestimation of PREFUL-QDP compared with PBF-QDP, mainly in the lower lobes, resulting in an overall overestimation for the whole lung with a mean difference of 5% (95% confidence interval [CI]: 3.0%; 7.0%; STD 6.8%). Data Conclusion: PREFUL-MRI is a promising noninvasive, radiation-free tool for quantification of regional perfusion in COPD patients. Level of Evidence: 1 Technical Efficacy: Stage 2

show abstract

Feasibility of quantitative regional ventilation and perfusion mapping with phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients

Cited by 148 publications

References 25 publications

MRI‐derived regional flow‐volume loop parameters detect early‐stage chronic lung allograft dysfunction

MRI‐derived regional flow‐volume loop parameters detect early‐stage chronic lung allograft dysfunction

Nonuniform Fourier‐decomposition MRI for ventilation‐ and perfusion‐weighted imaging of the lung

Comparison of quantitative regional perfusion‐weighted phase resolved functional lung (PREFUL) MRI with dynamic gadolinium‐enhanced regional pulmonary perfusion MRI in COPD patients

Contact Info

Product

Resources

About