Feasibility of quantitative parameters of dynamically enhanced patterns of spiral computed tomography scanning integrated into tumour progression before targeted treatment of non‐small cell lung cancer

Qiao, Pengyan; Huang, Qiong; Zhou, Juan; Wang, Xiang-Chao; Li, Ming; Ma, Jin-Lin; Tian, Ning; Li, Gongjie

doi:10.1111/1754-9485.12277

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…Spectral CT has potential advantages in lung cancer, as it can simultaneously provide enhanced images and a variety of quantitative parameters, which can be used for both routine diagnosis and functional evaluation ( 16 ). Perfusion CT can evaluate hemodynamic changes in tumors quantitatively, especially in evaluating the efficacy of tumor anti-vascular therapy ( 42 , 43 ). Hemodynamic changes during treatment usually precede morphological changes.…”

Section: Discussionmentioning

confidence: 99%

Can spectral computed tomography (CT) replace perfusion CT to assess the histological classification of non-small cell lung cancer?

Deng¹,

Yang²,

Jing³

et al. 2023

Quant Imaging Med Surg

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Background Non-small cell lung cancer (NSCLC) accounts for 80% of total lung cancer cases, it is necessary to distinguish the histological types of NSCLC. This study set out to investigate the correlation between spectral computed tomography (CT) and CT perfusion parameters in patients with NSCLC and to compare the differential diagnostic efficacy of these two imaging modalities for the histological classification of NSCLC. Methods A total of 62 eligible consecutive patients, including 32 with lung adenocarcinoma (LUAD) and 30 with lung squamous cell carcinoma (LUSC), who underwent “one-stop” spectral combined perfusion scan and pathologically confirmed NSCLC at Lanzhou University Second Hospital between September 2020 and December 2021 were prospectively enrolled. The spectral parameters of lesions in the arterial phase (AP) and venous phase (VP) [including iodine concentration (IC), effective atomic number (Zeff), CT 40keV , and slope of the spectral curve (K 70keV )] and perfusion parameters [blood flow (BF), blood volume (BV), surface permeability (PS), and mean transit time (MTT)] were assessed. Pearson or Spearman correlation analysis was performed to evaluate the correlation between the two imaging parameters, and the DeLong test was used to compare the diagnostic performance of the two imaging modalities. Results BV and BF were strongly correlated with spectral parameters CT 40keV , IC, Zeff, and K 70keV in the AP and VP (0.6

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Section: Discussionmentioning

confidence: 99%

Can spectral computed tomography (CT) replace perfusion CT to assess the histological classification of non-small cell lung cancer?

Deng¹,

Yang²,

Jing³

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

Feasibility of quantitative parameters of dynamically enhanced patterns of spiral computed tomography scanning integrated into tumour progression before targeted treatment of non‐small cell lung cancer

Abstract: The NSCLC patients with high perfusion value before targeted therapy are more sensitive to targeted therapy, and further experiments with larger sample size are needed.

Cited by 1 publication

References 18 publications

Can spectral computed tomography (CT) replace perfusion CT to assess the histological classification of non-small cell lung cancer?

Can spectral computed tomography (CT) replace perfusion CT to assess the histological classification of non-small cell lung cancer?

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