Feasibility of quantitative diffusion imaging of the heart in post-mortem MR

Crooijmans, Hendrikus J.A.; Ruder, Thomas D.; Zech, Wolf-Dieter; Somaini, Sandra; Scheffler, Klaus; Thali, Michael J.; Bieri, Oliver

doi:10.1016/j.jofri.2013.05.009

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…In our study, a similar trend was observed, particularly with regard to MD, although not reaching statistical significance. In addition, results for FA and MD are within the same order of magnitude as described in two post-mortem cases with ischemic heart disease [12]. Mean MD as observed post-mortem was approximately twice as low as that observed with in vivo DTI [2].…”

Section: Discussionsupporting

confidence: 78%

“…More specifically, conventional MRI exploiting T1, T2, and proton density (PD)-weighted imaging contrast enabled the detection of myocardial oedema and haemorrhage after MI [8,9]. Although the applicability of cardiac DTI to MRI has been investigated [10][11][12], its diagnostic performance has not yet been systematically studied for the detection of MI in post-mortem studies.…”

Section: Introductionmentioning

confidence: 99%

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Post-mortem cardiac diffusion tensor imaging: detection of myocardial infarction and remodeling of myofiber architecture

et al. 2014

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Post-mortem cardiac diffusion tensor imaging: detection of myocardial infarction and remodeling of myofiber architecture

et al. 2014

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“…6,31,67,68 However, these findings are often very subtle, and their interpretation depends on the subjective judgment of the investigator. 45,70 In addition, several critical parameters such as post-mortem interval, duration of ischemia, degree of occlusion, extent of collateral circulation and occurrence of vascular reperfusion are often unknown in postmortem investigations, and their impact on the appearance of ischaemic injury on PMMR is unaccounted for. To make matters more complex, post-mortem changes such as gas formation and low body temperature may further alter or degrade the PMMR image.…”

Section: Cardiovascular Imagingmentioning

confidence: 99%

“…70,71 It is hoped that quantitative evaluation of PMMR will decrease observer variability and better differentiate pathology from normal post-mortem changes, thereby improving the often challenging comparison between PMMR and autopsy findings in cases of sudden cardiac death.…”

Section: Cardiovascular Imagingmentioning

confidence: 99%

Essentials of forensic post-mortem MR imaging in adults

Ruder¹,

Thali²,

Hatch³

2014

BJR

120

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“…Investigators have encountered variably successful results in identifying ischemic myocardium with PMCTa ((3), (9). PMMR imaging has been shown to be effective in the detection of acute, evolving and remote myocardial ischemia and infarction (22–24).…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Utility of Postmortem Computed Tomography in the Diagnosis of Lethal Coronary Artery Atherosclerosis and Hypertensive Heart Disease

Snyder

Andrews

Curry

et al. 2015

Academic Forensic Pathology

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Autopsy is regarded as the gold standard for evaluation of human remains in the forensic pathology setting. Amongst the most common causes of death in any medical examiner jurisdiction are atherosclerotic cardiovascular disease and/or hypertensive cardiovascular disease. Practical experience shows that noncontrast “screening” postmortem computed tomography (PMCT) does not accurately document or diagnose lethal coronary artery atherosclerosis, nor does it allow for the diagnosis of hypertensive cardiovascular disease. One hundred adult forensic autopsies were selected from an 18-month period for this blinded, retrospective case-controlled study. The cases were composed of two age- and sex-matched groups by cause of death: 1) those due to hypertensive and atherosclerotic cardiovascular disease and 2) those due to other causes. Two forensic pathologists, blinded to the cause of death, reviewed pre-autopsy PMCT scans of the chest and recorded the presence or absence of clinically significant coronary artery stenosis, myocardial pathology (including left ventricular hypertrophy and myocardial infarction), cardiomegaly, and coronary artery calcium deposition. The same set of data was obtained from the corresponding autopsy reports. Results of the PMCT interpretations were compared with the results obtained from autopsy. Assessment of PMCT scans resulted in missing all 56 cases with severe coronary artery atherosclerosis, 50 cases with myocardial pathology, and 44 cases with cardiomegaly. Although PMCT did prove sensitive and superior for the detection of coronary artery calcification, this finding is clinically insignificant and of limited to no value to the vast majority of cases.

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Feasibility of quantitative diffusion imaging of the heart in post-mortem MR

Cited by 5 publications

References 23 publications

Post-mortem cardiac diffusion tensor imaging: detection of myocardial infarction and remodeling of myofiber architecture

Post-mortem cardiac diffusion tensor imaging: detection of myocardial infarction and remodeling of myofiber architecture

Essentials of forensic post-mortem MR imaging in adults

An Evaluation of the Utility of Postmortem Computed Tomography in the Diagnosis of Lethal Coronary Artery Atherosclerosis and Hypertensive Heart Disease

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