Feasibility Of NIH Consensus Criteria For Chronic Graft-Versus-Host Disease (GVHD): Successful Efforts In Establishing A Multicenter Brazil-Seattle Collaborative Consortium

Vigorito, Afonso Celso; Miranda, Eliana Cristina Martins; Bouzas, Luis Fernando; Moreira, Mariane Rossato; Silva, M.M.; Tavares, Raphael; Corrêa, Matheus; Funke, VAM; Nunes, Éllen Almeida; Colturato, Vergilio A.R.; Pedro, A.; Sousa, Mair Pedro de; Mauad, Marcos Augusto; Camacho, Kátia; Souza, Clarissa Vasconcellos de; Lee, S.J.; Flowers, Mary E.D.

doi:10.1016/j.bbmt.2009.12.470

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“…The GeDECH is a multidisciplinary team of HSCT physicians, a dermatologist, a psychiatrist, psychologists, dentists, physical therapists, nurses, an epidemiologist and a data manager. A multicenter pilot study on the feasibility of applying the criteria of the NIH consensus by the GeDECH was presented at the American Society for Blood and Marrow Transplantation in 2010 ( 7 ) and is now in press. ( 8 )…”

Section: Introductionmentioning

confidence: 99%

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Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations

Tavares¹,

Silva²,

Bouzas³

et al. 2011

Rev. Bras. Hematol. Hemoter.

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BackgroundThe lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials.MethodHere we describe a one-day workshop model conducted by the Chronic Graft-versus-Host Disease Brazil-Seattle Consortium Study Group to train investigators interested in participating in multicenter clinical trials in Brazil. Workshop participants included eight transplant physicians, one dermatologist, two dentists, three physical therapists and one psychologist from five institutions. Workshop participants evaluated nine patients with varying degrees of severity of mucocutaneous lesions and other manifestations of the disease followed by a training session to review and discuss the issues encountered with the evaluation and scoring of patients and in the methods used to evaluate grip strength and the 2-minute walk test.ResultsMost participants had difficulties in rating the percentage of each type of mucocutaneous lesion and thought 20 minutes was insufficient to evaluate and record the scores of each patient using the National Institutes of Health criteria and other cutaneous assessments. Several specific areas of difficulties encountered by the evaluators were: 1) determining the percentage of erythema in movable and non-movable sclerosis, 2) whether to score all cutaneous findings in a particular area or just the dominant lesion; 3) clarification of the definition of poikiloderma in chronic graft-versus-host disease; 4) discrepant interpretation of the mouth score and 5) clarification on the methodology used for the evaluation of grip strength and the 2-minute walk tests.ConclusionsResults of this workshop support the need to train investigators participating in clinical trials on chronic graft-versus-host disease.

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Section: Introductionmentioning

confidence: 99%

“…A multicenter pilot study on the feasibility of applying the criteria of the NIH consensus by the GeDECH was presented at the American Society for Blood and Marrow Transplantation in 2010 ( 7 ) and is now in press. ( 8 )…”

Section: Introductionmentioning

confidence: 99%