Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning

Fortunati, Valerio; Verhaart, René F.; Angeloni, Francesco; Lugt, Aad van der; Niessen, Wiro J.; Veenland, Jifke F.; Paulides, Margarethus M.; Walsum, Theo van

doi:10.1016/j.ijrobp.2014.05.027

Cited by 48 publications

(40 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adaptation of the 3D patient and applicator (e.g. water bolus-shape) models based on MRI scanning during MR guided hyperthermia is theoretically feasible, but the adaptation combined with re-calculation of the electromagnetic fields per antenna is currently challenging [86,103,104]. Other future real-time simulation improvement options during MR guided hyperthermia include correcting for applicator mismatches [97,105] and-/or imaging the properties per tissue, e.g.…”

Section: Simulation-guided Adaptive Hyperthermia Techniquesmentioning

confidence: 99%

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Datta

Ordóñez

Gaipl

et al. 2015

Cancer Treatment Reviews

445

393

View full text Add to dashboard Cite

Section: Simulation-guided Adaptive Hyperthermia Techniquesmentioning

confidence: 99%

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Datta

Ordóñez

Gaipl

et al. 2015

Cancer Treatment Reviews

445

393

View full text Add to dashboard Cite

“…25,26 Several previous studies have aimed to evaluate the performance of multimodal deformable registration and found promising geometric matching using different software and deformation algorithms for different sites. [27][28][29][30][31][32][33][34] Other studies have used  as a tool to better compare the dose calculated on the CT and calibrated CBCT. 35 However, residual discrepancies due to inaccuracies of  might exist, which have not been addressed.…”

Section: Introductionmentioning

confidence: 99%

Validation of a deformable image registration technique for cone beam CT‐based dose verification

et al. 2015

View full text Add to dashboard Cite

Purpose: As radiation therapy evolves toward more adaptive techniques, image guidance plays an increasingly important role, not only in patient setup but also in monitoring the delivered dose and adapting the treatment to patient changes. This study aimed to validate a method for evaluation of delivered intensity modulated radiotherapy (IMRT) dose based on multimodal deformable image registration () for prostate treatments. Methods: A pelvic phantom was scanned with CT and cone-beam computed tomography (CBCT). Both images were digitally deformed using two realistic patient-based deformation fields. The original CT was then registered to the deformed CBCT resulting in a secondary deformed CT. The registration quality was assessed as the ability of the  method to recover the artificially induced deformations. The primary and secondary deformed CT images as well as vector fields were compared to evaluate the efficacy of the registration method and it's suitability to be used for dose calculation. , a free and open source software was used for deformable image registration. A B-spline algorithm with optimized parameters was used to achieve the best registration quality. Geometric image evaluation was performed through voxel-based Hounsfield unit (HU) and vector field comparison. For dosimetric evaluation, IMRT treatment plans were created and optimized on the original CT image and recomputed on the two warped images to be compared. The dose volume histograms were compared for the warped structures that were identical in both warped images. This procedure was repeated for the phantom with full, half full, and empty bladder. Results: The results indicated mean HU differences of up to 120 between registered and ground-truth deformed CT images. However, when the CBCT intensities were calibrated using a region of interest (ROI)-based calibration curve, these differences were reduced by up to 60%. Similarly, the mean differences in average vector field lengths decreased from 10.1 to 2.5 mm when CBCT was calibrated prior to registration. The results showed no dependence on the level of bladder filling. In comparison with the dose calculated on the primary deformed CT, differences in mean dose averaged over all organs were 0.2% and 3.9% for dose calculated on the secondary deformed CT with and without CBCT calibration, respectively, and 0.5% for dose calculated directly on the calibrated CBCT, for the full-bladder scenario. Gamma analysis for the distance to agreement of 2 mm and 2% of prescribed dose indicated a pass rate of 100% for both cases involving calibrated CBCT and on average 86% without CBCT calibration. Conclusions: Using deformable registration on the planning CT images to evaluate the IMRT dose based on daily CBCTs was found feasible. The proposed method will provide an accurate dose distribution using planning CT and pretreatment CBCT data, avoiding the additional uncertainties introduced by CBCT inhomogeneity and artifacts. This is a necessary initial step toward future imageguided adaptive ...

show abstract

“…For all sets, the CT images were acquired once with the same positioning equipment. Set B has also been used by our group in a previous study [16]. Details about the image acquisition parameters and the image characteristics are given in Appendix A.…”

Section: Methodsmentioning

confidence: 99%

“…The use of deformable intra-patient registration in multi-modal H&N imaging has recently been investigated [14][15][16]. In the first two studies, immobilization equipment was not used and, when patients were scanned in free position, in both studies deformable registration was more accurate than rigid registration.…”

Section: Introductionmentioning

confidence: 99%

MRI integration into treatment planning of head and neck tumors: Can patient immobilization be avoided?

Fortunati

Verhaart

Verduijn

et al. 2015

Radiotherapy and Oncology

Self Cite

View full text Add to dashboard Cite

Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning

Cited by 48 publications

References 30 publications

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Validation of a deformable image registration technique for cone beam CT‐based dose verification

MRI integration into treatment planning of head and neck tumors: Can patient immobilization be avoided?

Contact Info

Product

Resources

About