Feasibility of minimally invasive, same-day injection of autologous adipose-derived stem cells in the treatment of erectile dysfunction

Fode, Mikkel; Nadler, Naomi; Lund, Lars; Azawi, Nessn

doi:10.1080/21681805.2022.2162117

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Similar results to the recent clinical study with adipose-derived stem cells were published by Fode et al [ 60 ] A prospective case series of 10 men was conducted to investigate the feasibility and safety of a new minimally invasive same-day method of autologous adipose-derived stem cell (ADSC) transplantation using the myStem ® X2 kit.…”

Section: Resultsmentioning

confidence: 55%

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Pérez-Aizpurua

Garranzo-Ibarrola

Simón-Rodríguez

et al. 2023

Life

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Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms “erectile dysfunction” and “stem cell therapy” in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit.

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Section: Resultsmentioning

confidence: 55%

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Pérez-Aizpurua

Garranzo-Ibarrola

Simón-Rodríguez

et al. 2023

Life

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“…ADSCs are particularly interesting for their relative abundance and the ease of the isolation procedure compared to other MSC subtypes [ 19 , 145 , 146 ]. Regenerative medicine and immune-mediated disorders certainly represent the principal applications for ADSC-based strategies [ 16 , 147 , 148 , 149 , 150 , 151 , 152 ]. As well as for other MSC sources, ADSC therapeutic functions are mostly mediated by the production of extracellular vesicles and the secretion of specific soluble mediators [ 153 , 154 ].…”

Section: Mscs and Wound Healingmentioning

confidence: 99%

Obesity and Wound Healing: Focus on Mesenchymal Stem Cells

Alma

Marconi

Rossi

et al. 2023

Life

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Chronic wounds represent nowadays a major challenge for both clinicians and researchers in the regenerative setting. Obesity represents one of the major comorbidities in patients affected by chronic ulcers and therefore diverse studies aimed at assessing possible links between these two morbid conditions are currently ongoing. In particular, adipose tissue has recently been described as having metabolic and endocrine functions rather than serving as a mere fat storage deposit. In this setting, adipose-derived stem cells, a peculiar subset of mesenchymal stromal/stem cells (MSCs) located in adipose tissue, have been demonstrated to possess regenerative and immunological functions with a key role in regulating both adipocyte function and skin regeneration. The aim of the present review is to give an overview of the most recent findings on wound healing, with a special focus on adipose tissue biology and obesity.

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“…New MSC-based therapeutic strategies have demonstrated promising results in clinical practice, including the treatment of nerve damage, inflammation, and transplantation [ 8 ]. The MSC therapy for ED is still being studied in clinical trials [ 9 ]. Many studies have revealed positive outcomes of MSC therapy on ED [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Erectile Dysfunction Treatment Using Stem Cell Delivery Patch in a Cavernous Nerve Injury Rat Model

Moon

Kim

et al. 2023

Bioengineering

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Erectile dysfunction (ED) is a common and feared complication of radical prostatectomy (RP) for prostate cancer. Recently, tissue engineering for post-prostatectomy ED has been attempted in which controlled interactions between cells, growth factors, and the extracellular matrix (ECM) are important for the structural integrity if nerve regeneration. In this study, we evaluated the effects of a biomechanical ECM patch on the morphology and behavior of human bone marrow-derived mesenchymal stem cells (hBMSCs) in a bilateral cavernous nerve injury (BCNI) rat model. The ECM patch, made of decellularized human fibroblast-derived ECM (hFDM) and a biocompatible polyvinyl alcohol (PVA) hydrogel, was tested with human bone marrow-derived mesenchymal stem cells (hBMSCs) on a bilateral cavernous nerve injury (BCNI) rat model. In vitro analysis showed that the hFDM/PVA + hBMSCs patches significantly increased neural development markers. In vivo experiments demonstrated that the rats treated with the hFDM/PVA patch had higher ICP/MAP ratios, higher ratios of smooth muscle to collagen, increased nNOS content, higher levels of eNOS protein expression, and higher cGMP levels compared to the BCNI group. These results indicate that the hFDM/PVA patch is effective in promoting angiogenesis, smooth muscle regeneration, and nitrergic nerve regeneration, which could contribute to improved erectile function in post-prostatectomy ED.

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Feasibility of minimally invasive, same-day injection of autologous adipose-derived stem cells in the treatment of erectile dysfunction

Cited by 7 publications

References 14 publications

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Obesity and Wound Healing: Focus on Mesenchymal Stem Cells

Erectile Dysfunction Treatment Using Stem Cell Delivery Patch in a Cavernous Nerve Injury Rat Model

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