Feasibility of Mid-Frequency Ventilation Among Infants With Respiratory Distress Syndrome

Bhat, Ramesh M; Kelleher, John; Ambalavanan, Namasivayam; Chatburn, Robert L; Mireles-Cabodevila, Eduardo; Carlo, Waldemar A.

doi:10.4187/respcare.05157

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…In 2013, Chatburn and Mireles-Cabodevila extended this equation to predict alveolar minute volume as a function of frequency and invented a new optimal targeting scheme called mid-frequency ventilation (MFV) [ 28 ]. MFV is designed to maximize alveolar minute ventilation for a given inspiratory pressure target [ 28 ] or minimize inspiratory pressure target for a target minute alveolar ventilation [ 29 ] (inspiratory pressure target, P insp , is the preset pressure change above PEEP set on the ventilator, i.e., the amplitude of the square pressure waveform).…”

Section: Methodsmentioning

confidence: 99%

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Advanced modes of mechanical ventilation and optimal targeting schemes

Staay

Chatburn

2018

ICMx

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Recent research results provide new incentives to recognize and prevent ventilator-induced lung injury (VILI) and create targeting schemes for new modes of mechanical ventilation. For example, minimization of breathing power, inspiratory power, and inspiratory pressure are the underlying goals of optimum targeting schemes used in the modes called adaptive support ventilation (ASV), adaptive ventilation mode 2 (AVM2), and MID-frequency ventilation (MFV). We describe the mathematical models underlying these targeting schemes and present theoretical analyses for minimizing tidal volume, tidal pressure (also known as driving pressure), or tidal power as functions of ventilatory frequency. To go beyond theoretical equations, these targeting schemes were compared in terms of expected tidal volumes using different patient models. Results indicate that at the same ventilation efficiency (same PaCO2 level), we expect tidal volume dosage in the range of 7.4 mL/kg (for ASV), 6.2 mL/kg (for AVM2), and 6.7 mL/kg (for MFV) for adult ARDS simulation. For a neonatal RDS model, we expect 5.5 mL/kg (for ASV), 4.6 mL/kg (for AVM2), and 4.5 (for MFV).Electronic supplementary materialThe online version of this article (10.1186/s40635-018-0195-0) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

“…Recently, a randomized controlled trial compared MFV to volume targeted ventilation (i.e., pressure control ventilation with adaptive targeting). Again, inspiratory pressures and tidal volumes were lower during mid-frequency ventilation [ 29 ].…”

Section: Evidence For Optimum Targeting Schemesmentioning

confidence: 99%